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Evaluation of a novel nanocrystalline hydroxyapatite paste and a solid hydroxyapatite ceramic for the treatment of critical size bone defects (CSD) in rabbits

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Abstract

The purpose of our study was to test the effectiveness of Ostim nanocrystalline hydroxyapatite paste and Cerabone ceramic by treating a critical size bone defect (CSD) on the right foreleg of a white New Zealand rabbit. Evaluation was carried out by comparing four groups each with a different CSD filling: an only OSTIM bone filling, an only Cerabone filling, an OSTIM–Cerabone combination, and a control group with no filling of the CSD. The results of this study display a rapid and uniform bone ingrowth following the CSD filling with Ostim. The histological and histomorphometrical data have shown similarly excellent results for both the Ostim and Cerabone–Ostim groups. The control group faired poorly in comparison, as three cases of non-union were observed and none of the defects were totally refilled with fresh bone within 60 days. The successful bone healing with osseous consolidation verifies the importance of the nanocrystalline hydroxyapatite in the treatment of metaphyseal osseous volume defects in the metaphyseal spongiosa.

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Authors and Affiliations

  1. Surgical Clinic, Division of Traumatology and Reconstructive Surgery, University of Heidelberg, INF 110, 69120, Heidelberg, Germany

    Franz-Xaver Huber & Peter Jürgen Meeder

  2. Department of General Pathology, University of Heidelberg, INF 220/221, 69120, Heidelberg, Germany

    Irina Berger

  3. Department of General Surgery, Fürst-Stirum-Hospital Bruchsal, Gutleutstr. 1-14, 76646, Bruchsal, Germany

    Nicholas McArthur

  4. Department of Internal Medicine, Luisenhospital Lindenfels, Schlierbacher Weg, 64678, Lindenfels/Odenwald, Germany

    Colette Huber

  5. Department of Trauma Surgery, Hospital Bad Homburg, Urseler Str. 33, 61348, Bad Homburg v.d.H., Germany

    Hans-Peter Kock

  6. Department of Trauma Surgery, St Vincenz Hospital, Auf dem Schafsberg, 65549, Limburg, Germany

    Jürgen Hillmeier

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  1. Franz-Xaver Huber
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  2. Irina Berger
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  3. Nicholas McArthur
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  4. Colette Huber
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  7. Peter Jürgen Meeder
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Correspondence to Franz-Xaver Huber.

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Huber, FX., Berger, I., McArthur, N. et al. Evaluation of a novel nanocrystalline hydroxyapatite paste and a solid hydroxyapatite ceramic for the treatment of critical size bone defects (CSD) in rabbits. J Mater Sci: Mater Med 19, 33–38 (2008). https://doi.org/10.1007/s10856-007-3039-0

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  • DOI: https://doi.org/10.1007/s10856-007-3039-0

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