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Development of graded hydroxyapatite/CaCO3 composite structures for bone ingrowth

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Abstract

Ceramic composites composed of constituents with different bone cell reactions present an interesting consideration for a new bone replacement material. The first component of the composite used in this study, hydroxyapatite, is known to be replaced by natural tissue significantly slower than the second, calcium carbonate, which has limited structural stability. A graded hydroxyapatite/calcium carbonate composite with bimodal component distribution was developed using a combined slip infiltration and dip-coating technique from a porous polyurethane sponge replica. A graded hydroxyapatite scaffold with porosities from 5 to 90% was produced and then infiltrated with a calcium carbonate slip and sintered. The resultant composite had improved mechanical properties compared with the monolith as measured by crushing and moduli tests.

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Acknowledgements

The authors gratefully acknowledge previous work by Achim Neubrand (Fraunhofer-Institut für Werkstoffmechanik, Freiburg, Germany), Matthew Tilbrook and Lyndal Kidson (both former PhD students at the School of Materials Science and Engineering, UNSW) on sponge replica methods for graded alumina. This work provided the basis to develop the porous hydroxyapatite structures described in this paper. The authors also thank Katie Levick and Jenny Norman (both of the Electron Microscope Unit, UNSW) for their many hours spent in optimising the Micro-CT image capturing parameters, which greatly improved the quality of the results. Lastly, the authors thank Viera Piergova (Electron Microscope Unit, UNSW) for the training in SEM use and constant suggestions for improvement of capturing SEM images.

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Authors and Affiliations

  1. Department of Materials Science (III)—Biomaterials, University of Erlangen-Nürnberg, Henkestr 91, 91052, Erlangen, Germany

    F. Heilmann & F. A. Müller

  2. School of Materials Science and Engineering, University of New South Wales (UNSW), Sydney, NSW, 2052, Australia

    F. Heilmann, O. C. Standard & M. Hoffman

Authors
  1. F. Heilmann
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  2. O. C. Standard
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  3. F. A. Müller
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  4. M. Hoffman
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Correspondence to M. Hoffman.

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Heilmann, F., Standard, O.C., Müller, F.A. et al. Development of graded hydroxyapatite/CaCO3 composite structures for bone ingrowth. J Mater Sci: Mater Med 18, 1817–1824 (2007). https://doi.org/10.1007/s10856-007-3028-3

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  • DOI: https://doi.org/10.1007/s10856-007-3028-3

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