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Surface tailoring of poly(ethylene terephthalate) via ligand-tethered comb-like PEG to enhance endothelialization

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Abstract

The comb-like PEG (CPEG) end-tethered with l-lysine was explored to surface modification of PET to enhance endothelialization. The hydroxyl end groups of CPEG were oxygenated into aldehyde groups. The CPEG-CHO was grafted onto the aminolysized PET. The l-lysine was then end-tethered onto surface via the residual aldehyde groups. The surface modification was confirmed by ATR-FTIR, contact angle and XPS measurements. The endothelial cell adhesion, proliferation and viability results indicated that the PET-CPEG resisted cell adhesion and growth, where as PET-CPEG-lysine promoted cell adhesion and growth. The MTT assay and total cell protein tests indicated that the endothelial cells on PET-CPEG-lysine had high viability. Cell spread uniformly and covered completely on the PET-CPEG-lysine. The CPEG end tethered with l-lysine could regulate cell adhesion and growth and enhance surface endotheliazation.

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Acknowledgements

This research was financially supported by Major State Basic Research Foundation of China (grant No. 2005CB623902), Natural Science Foundation of Chain (NSFC-20174035), Program for New Century Excellent Talents in University (NCET-05-0527) and National High Technology Research and Development Program of China (2006AA03Z329).

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Authors and Affiliations

  1. Department of Polymer Science, Zhejiang University, Hangzhou, 310027, China

    Xiaolin Li, Jian Ji, Ming Pu, Xiaoli Wang & Jiacong Shen

  2. Key Laboratory of Macromolecule Synthesis and Functionalzation of Minster of Education, Zhejiang University, Hangzhou, 310027, China

    Jian Ji & Jiacong Shen

Authors
  1. Xiaolin Li
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  2. Jian Ji
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  3. Ming Pu
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  4. Xiaoli Wang
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Correspondence to Jian Ji.

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Li, X., Ji, J., Pu, M. et al. Surface tailoring of poly(ethylene terephthalate) via ligand-tethered comb-like PEG to enhance endothelialization. J Mater Sci: Mater Med 19, 291–299 (2008). https://doi.org/10.1007/s10856-006-0110-1

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  • DOI: https://doi.org/10.1007/s10856-006-0110-1

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