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The effect of oxide thickness on osteoblast attachment and survival on NiTi alloy

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Abstract

NiTi alloy is used in various medical applications and the surface titanium oxide layer produced naturally or enhanced artificially has been thought to offer a protecting film against allergic and toxic effects of nickel (Ni). In this study, we investigated the effect of different oxide layer thicknesses on the survival and attachment of osteoblastic cells (ROS-17/2.8). AFM, X-ray diffraction and electrical resistance measurements were used to analyze the surface properties of oxidized NiTi samples and the effect of oxidation on material properties. The results clearly showed that straight correlation between oxide thickness and cellular well-being cannot be maid. However, the different thicknesses of oxide layer on NiTi had surprising impacts on cellular responses and also to the properties of the metal alloy.

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Acknowledgments

The authors thank Ms. Taina Poikela for technical assistance. This work was supported in part by the National Technology Agency of Finland (40245/03). V. M. was supported by the National Graduate School for Musculoskeletal Diseases in Finland.

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology, University of Oulu, P.O. Box 5000, 90014, Oulu, Finland

    V. Muhonen & J. Tuukkanen

  2. Department of Medical Technology, University of Oulu, P.O. Box 5000, 90014, Oulu, Finland

    V. Muhonen, R. Heikkinen, A. Danilov & T. Jämsä

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  1. V. Muhonen
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  2. R. Heikkinen
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  3. A. Danilov
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  4. T. Jämsä
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  5. J. Tuukkanen
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Correspondence to V. Muhonen.

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Muhonen, V., Heikkinen, R., Danilov, A. et al. The effect of oxide thickness on osteoblast attachment and survival on NiTi alloy. J Mater Sci: Mater Med 18, 959–967 (2007). https://doi.org/10.1007/s10856-006-0082-1

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  • DOI: https://doi.org/10.1007/s10856-006-0082-1

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