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Preparation and characterization of theophylline loaded chitosan/β-cyclodextrin microspheres

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Abstract

The purpose of this project was to develop sustained release chitosan/β-cyclodextrin microspheres of theophylline (TH) prepared by spray drying method. The effect of several formulation variables on the characteristics of microspheres was studied. The B microspheres had a narrower particle size distribution with the diameter between l and 10 μm. SEM showed spherical microspheres with smooth or slightly wrinkled surfaces. FT-IR spectroscopy revealed that hydrogen bonds were formed between TH and chitosan or β-cyclodextrin. The drug entrapments significantly increased from 13.33 to 35.70% with an increase of the ratio of drug/polymer. The encapsulation efficiencies were from 85.16 to 91.40%. The in vitro release of TH from microspheres was related to the pH of the medium, swelling ability, especially in the ratio of drug/polymer. The B microspheres had a prolonged release pattern with the release rate of 60.20% (pH 6.8) within 8 h.

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Acknowledgements

The authors are indebted to the financial support from NSFC (No. 30670566), ISTCP (No. 2006DFA33150) and the NSF of Shandong Province (No. Y2006C110).

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Authors and Affiliations

  1. College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao, 266003, P.R. China

    Wei Fen Zhang, Xi Guang Chen, Pi Wu Li & Hui Yun Zhou

  2. Shandong Academy of Food and Fermentation Industries, Jinan, 250000, P.R. China

    Pi Wu Li & Qiang Zhi He

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  1. Wei Fen Zhang
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  2. Xi Guang Chen
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  3. Pi Wu Li
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Correspondence to Xi Guang Chen.

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Zhang, W.F., Chen, X.G., Li, P.W. et al. Preparation and characterization of theophylline loaded chitosan/β-cyclodextrin microspheres. J Mater Sci: Mater Med 19, 305–310 (2008). https://doi.org/10.1007/s10856-006-0021-1

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  • DOI: https://doi.org/10.1007/s10856-006-0021-1

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