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Release behavior and kinetic evaluation of berberine hydrochloride from ethyl cellulose/chitosan microspheres

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Abstract

Novel ethyl cellulose/chitosan microspheres (ECCMs) were prepared by the method of w/o/w emulsion and solvent evaporation. The microspheres were spherical, adhesive, and aggregated loosely with a size not bigger than 5 μm. The drug loading efficiency of berberine hydrochloride (BH) loaded in microspheres were affected by chitosan (CS) concentration, EC concentration and the volume ratio of V(CS)/V(EC). ECCMs prepared had sustained release efficiency on BH which was changed with different preparation parameters. In addition, the pH value of release media had obvious effect on the release character of ECCMs. The release rate of BH from sample B was only a little more than 30% in diluted hydrochloric acid (dHCl) and that was almost 90% in PBS during 24 h. Furthermore, the drug release data were fitted to different kinetic models to analyze the release kinetics and the mechanism from the microspheres. The released results of BH indicated that ECCMs exhibited non-Fickian diffusion mechanism in dHCl and diffusion-controlled drug release based on Fickian diffusion in PBS. So the ECCMs might be an ideal sustained release system especially in dHCl and the drug release was governed by both diffusion of the drug and dissolution of the polymeric network.

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References

  1. Rinaudo M. Chitin and chitosan: Properties and applications. Progress in Polymer Science, 2006, 31(7): 603–632

    Article  Google Scholar 

  2. Dash M, Chiellini F, Ottenbrite R M, et al. Chitosan—Aversatile semi-synthetic polymer in biomedical applications. Progress in Polymer Science, 2011, 36(8): 981–1014

    Article  Google Scholar 

  3. Mukhopadhyay P, Mishra R, Rana D, et al. Strategies for effective oral insulin delivery with modified chitosan nanoparticles: A review. Progress in Polymer Science, 2012, 37(11): 1457–1475

    Article  Google Scholar 

  4. Liu W-F, Kang C-Z, Kong M, et al. Controlled release behaviors of chitosan/α, β-glycerophosphate thermo-sensitive hydrogels. Frontiers of Materials Science, 2012, 6(3): 250–258

    Article  Google Scholar 

  5. Liu Y, Ma L, Gao C. Facile fabrication of the glutaraldehyde cross-linked collagen/chitosan porous scaffold for skin tissue engineering. Materials Science and Engineering C, 2012, 32(8): 2361–2366

    Article  Google Scholar 

  6. Young T-H, Wang I-J, Hu F-R, et al. Fabrication of a bioengineered corneal endothelial cell sheet using chitosan/polycaprolactone blend membranes. Colloids and Surfaces B: Biointerfaces, 2014, 116: 403–410

    Article  Google Scholar 

  7. Hu H L, Tang C, Yin C H. Folate conjugated trimethyl chitosan/graphene oxide nanocomplexes as potential carriers for drug and gene delivery. Materials Letters, 2014, 125: 82–85

    Article  Google Scholar 

  8. An J, Ji Z, Wang D, et al. Preparation and characterization of uniform-sized chitosan/silver microspheres with antibacterial activities. Materials Science and Engineering C, 2014, 36: 33–41

    Article  Google Scholar 

  9. Ofokansi K C, Kenechukwu F C, Isah A B, et al. Formulation and evaluation of glutaraldehyde-crosslinked chitosan microparticles for the delivery of ibuprofen. Tropical Journal of Pharmaceutical Research, 2013, 12: 19–25

    Google Scholar 

  10. Tan S, Gao B, Tao Y, et al. Antiobese effects of capsaicin-chitosan microsphere (CCMS) in obese rats induced by high fat diet. Journal of Agricultural and Food Chemistry, 2014, 62(8): 1866–1874

    Article  Google Scholar 

  11. Zhang W F, Zhao X T, Zhao Q S, et al. Biocompatibility and characteristics of theophylline/carboxymethyl chitosan microspheres for pulmonary drug delivery. Polymer International, 2014, 63(6): 1035–1040

    Article  Google Scholar 

  12. Fodor-Kardos A, Toth J, Gyenis J. Preparation of protein loaded chitosan microparticles by combined precipitation and spherical agglomeration. Powder Technology, 2013, 244: 16–25

    Article  Google Scholar 

  13. Zhu N, Cooper D, Chen X-B, et al. A study on the in vitro degradation of poly(L-lactide)/chitosan microspheres scaffolds. Frontiers of Materials Science, 2013, 7(1): 76–82

    Article  Google Scholar 

  14. Fernandes M, Gonçalves I C, Nardecchia S, et al. Modulation of stability and mucoadhesive properties of chitosan microspheres for therapeutic gastric application. International Journal of Pharmaceutics, 2013, 454(1): 116–124

    Article  Google Scholar 

  15. Zhou H-Y, Zhou D-J, Zhang W-F, et al. Biocompatibility and characteristics of chitosan/cellulose acetate microspheres for drug delivery. Frontiers of Materials Science, 2011, 5(4): 367–378

    Article  Google Scholar 

  16. Calejo M T, Kjøniksen A L, Pinazo A, et al. Thermoresponsive hydrogels with low toxicity from mixtures of ethyl(hydroxyethyl) cellulose and arginine-based surfactants. International Journal of Pharmaceutics, 2012, 436(1-2): 454–462

    Article  Google Scholar 

  17. Feczkó T, Kovács M, Voncina B. Improvement of fatigue resistance of spirooxazine in ethyl cellulose and poly(methyl methacrylate) nanoparticles using a hindered amine light stabilizer. Journal of Photochemistry and Photobiology A: Chemistry, 2012, 247: 1–7

    Article  Google Scholar 

  18. Larsson M, Hjärtstam J, Berndtsson J, et al. Effect of ethanol on the water permeability of controlled release films composed of ethyl cellulose and hydroxypropyl cellulose. European Journal of Pharmaceutics and Biopharmaceutics, 2010, 76(3): 428–432

    Article  Google Scholar 

  19. Feng H, Zhang L, Zhu C. Genipin crosslinked ethyl cellulose-chitosan complex microspheres for anti-tuberculosis delivery. Colloids and Surfaces B: Biointerfaces, 2013, 103: 530–537

    Article  Google Scholar 

  20. Mirabedini S M, Dutil I, Farnood R R. Preparation and characterization of ethyl cellulose-based core-shell microcapsules containing plant oils. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2012, 394: 74–84

    Article  Google Scholar 

  21. Es-haghi H, Mirabedini S M, Imani M, et al. Preparation and characterization of pre-silane modified ethyl cellulose-based microcapsules containing linseed oil. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014, 447: 71–80

    Article  Google Scholar 

  22. Li Y, Cao R, Wu X, et al. Hypercrosslinked poly(styrene-codivinylbenzene) resin as a specific polymeric adsorbent for purification of berberine hydrochloride from aqueous solutions. Journal of Colloid and Interface Science, 2013, 400: 78–87

    Article  Google Scholar 

  23. Li H, Li Y, Li Z, et al. Preparation and adsorption behavior of berberine hydrochloride imprinted polymers by using silica gel as sacrificed support material. Applied Surface Science, 2012, 258(10): 4314–4321

    Article  Google Scholar 

  24. Ashjari M, Khoee S, Mahdavian A R. Controlling the morphology and surface property of magnetic/cisplatin-loaded nanocapsules via W/O/W double emulsion method. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2012, 408: 87–96

    Article  Google Scholar 

  25. Lee Y S, Johnson P J, Robbins P T, et al. Production of nanoparticles-in-microparticles by a double emulsion method: a comprehensive study. European Journal of Pharmaceutics and Biopharmaceutics, 2013, 83(2): 168–173

    Article  Google Scholar 

  26. Remuñán-López C, Lorenzo-Lamosa M L, Vila-Jato J L, et al. Development of new chitosan-cellulose multicore microparticles for controlled drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 1998, 45(1): 49–56

    Article  Google Scholar 

  27. Gui R, Wang Y, Sun J. Encapsulating magnetic and fluorescent mesoporous silica into thermosensitive chitosan microspheres for cell imaging and controlled drug release in vitro. Colloids and Surfaces B: Biointerfaces, 2014, 113: 1–9

    Article  Google Scholar 

  28. Zhou H Y, Chen X G, Kong M, et al. Preparation of chitosanbased thermosensitive hydrogels for drug delivery. Journal of Applied Polymer Science, 2009, 112(3): 1509–1515

    Article  Google Scholar 

  29. Malana MA, Zohra R. The release behavior and kinetic evaluation of tramadol HCl from chemically cross linked Ter polymeric hydrogels. DARU Journal of Pharmaceutical Sciences, 2013, 21(1): 10 (10 pages)

    Article  Google Scholar 

  30. Wahab A, Khan G M, Akhlaq M, et al. Pre-formulation investigation and in vitro evaluation of directly compressed ibuprofen-ethocel oral controlled release matrix tablets: A kinetic approach. African Journal of Pharmacy and Pharmacology, 2011, 5: 2118–2127

    Google Scholar 

  31. Higuchi T. Mechanism of sustained-action medication. theoretical analysis of rate of release of solid drugs dispersed in solid matrices. Journal of Pharmaceutical Sciences, 1963, 52(12): 1145–1149

    Article  Google Scholar 

  32. Siepmann J, Peppas N A. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Advanced Drug Delivery Reviews, 2001, 48(2-3): 139–157

    Article  Google Scholar 

  33. Zhou H-Y, Jiang L-J, Zhang Y-P, et al. β-Cyclodextrin inclusion complex: preparation, characterization, and its aspirin release in vitro. Frontiers of Materials Science, 2012, 6(3): 259–267

    Article  Google Scholar 

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Authors and Affiliations

  1. Chemical Engineering & Pharmaceutics College, Henan University of Science and Technology, Luoyang, 471023, China

    Hui-Yun Zhou, Pei-Pei Cao, Jie Zhao, Zhi-Ying Wang, Jun-Bo Li & Fa-Liang Zhang

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  1. Hui-Yun Zhou
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  2. Pei-Pei Cao
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  3. Jie Zhao
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Correspondence to Hui-Yun Zhou.

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Zhou, HY., Cao, PP., Zhao, J. et al. Release behavior and kinetic evaluation of berberine hydrochloride from ethyl cellulose/chitosan microspheres. Front. Mater. Sci. 8, 373–382 (2014). https://doi.org/10.1007/s11706-014-0269-1

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  • DOI: https://doi.org/10.1007/s11706-014-0269-1

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