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Electrochemical sensor based on molecularly imprinted poly-arginine for highly sensitive and selective erythromycin determination

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Abstract

As a macrolide antibiotic, erythromycin is often used to treat bacterial infections in animal husbandry, but excessive use of erythromycin will make its residue in the animal and subsequently enter the human body through consumption, furthermore causing a different degree of damage to human health. It is quite essential to develop a fast and precise quantitative detection manner for erythromycin. In this study, we use arginine as a functional monomer and erythromycin as a template molecule to electro-polymerize a layer of molecularly imprinted polymer film on the surface of a glassy carbon electrode, and then use it as a recognition element to achieve quantitative erythromycin monitoring. The linear detection range of the prepared electrochemical sensor is from 3 nM to 1600 µM, the lowest detection limit (S/N = 3) is 2.01 nM, and the sensitivity is 57,300 µA cm−2 µM−1. The selectivity, reproducibility, and stability of the electrochemical sensor are satisfactory. At the same time, it can monitor whether honey contains erythromycin and its concentration, the recovery rate from 96.4 to 104.2%. After a series of performance tests, the results indicated that the Arg-MIP/GCE sensor has the potential to be applied in the measurement of erythromycin, which exists in food and agro-products.

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This work described has not been published before. All data generated or analyzed during this study are included in this published article.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grand No. 61761047 and 41876055), Yunnan University’s Research Innovation Fund for Graduate Students (2021Z096), the Yunnan Provincial Department of Science and Technology through the Key Project for the Science and Technology (Grant No. 2017FA025), and Program for Innovative Research Team (in Science and Technology) in University of Yunnan Province.

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Authors and Affiliations

  1. School of Materials and Energy, Yunnan University, 6500504, Kunming, People’s Republic of China

    Tingrun Lai, Hui Shu, Xu Tian, Jie Ren, Xiuxiu Cui, Huiping Bai & Yude D. Wang

  2. Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies, Yunnan University, 650091, Kunming, People’s Republic of China

    Xuechun C. Xiao

  3. Key Lab of Quantum Information of Yunnan Province, Yunnan University, 6500504, Kunming, People’s Republic of China

    Yude D. Wang

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  1. Tingrun Lai
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  2. Hui Shu
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  3. Xu Tian
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  7. Xuechun C. Xiao
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Contributions

All authors contributed to the work conception and design. TL: Investigation, Original draft preparation. HB and XX: Investigation, Writing—Original draft preparation. HS, XT, XC, and JR: Data curation and Methodology. YW: Supervision, Writing—Reviewing and Editing. All authors read and approved the final manuscript.

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Correspondence to Xuechun C. Xiao or Yude D. Wang.

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Lai, T., Shu, H., Tian, X. et al. Electrochemical sensor based on molecularly imprinted poly-arginine for highly sensitive and selective erythromycin determination. J Mater Sci: Mater Electron 34, 6 (2023). https://doi.org/10.1007/s10854-022-09405-0

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