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Novel photothermal-responsive sandwich-structured mesoporous silica nanoparticles: synthesis, characterization, and application for controlled drug delivery

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Abstract

Novel thermal nanoparticles [hollow mesoporous silica nanospheres (HMSNs)–poly (N-isopropyl acrylamide-acrylic acid) PNIPAM-AA] were developed with Ag nanoparticles (AgNps) as the core, mesoporous silica nanoparticles as the layer, and thermally responsive polymers PNIPAM-AA as the shell. The AgNps had good photothermal effects, PNIPAM-AA was responsive to temperature, the combination of AgNps and PNIPAM-AA could be used as a photothermal-responsive switch for drug release, and HMSNs greatly increased the drug loading of the carrier. The samples were characterized by means of scanning electron microscopy, transmission electron microscopy, N2 adsorption–desorption, thermogravimetric analysis, Fourier transform infrared spectroscopy, and UV–Vis absorption spectra. The results showed that Ag@HMSN nanoparticles possessed a uniform diameter (330 nm), high specific surface area (822.45 m2/g), and mesoporous pore size (2.75 nm). Using ibuprofen (IBU) as a model drug, the release process was monitored under in vitro conditions to investigate its release characteristics at different temperatures. The results showed that the nanoparticles had a significant regulatory effect on IBU release.

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Acknowledgements

The work was supported by the National Research Foundation of Natural Science Foundation of Hebei Province of China (H2020209288).

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Authors and Affiliations

  1. North China University of Science and Technology, School of Pharmacy, Tangshan, Hebei, China

    Yipeng Qin, Yuhan Huang, Min Li, Bo Ren, Pan Wang, Qidi Zhong & Chunyan Liu

Authors
  1. Yipeng Qin
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  2. Yuhan Huang
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  3. Min Li
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  4. Bo Ren
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  5. Pan Wang
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  6. Qidi Zhong
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  7. Chunyan Liu
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Contributions

YQ helped in investigation, writing—original draft, software, methodology. YH contributed to writing—review and editing and methodology. ML helped in writing—review and editing and data curation. PW wrote the review and edited. QZ helped in conceptualization, supervision, writing—review and editing. BR and CYL contributed to conceptualization, project administration, funding acquisition, writing—review and editing.

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Correspondence to Bo Ren or Chunyan Liu.

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Handling Editor: Annela M. Seddon.

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Qin, Y., Huang, Y., Li, M. et al. Novel photothermal-responsive sandwich-structured mesoporous silica nanoparticles: synthesis, characterization, and application for controlled drug delivery. J Mater Sci 56, 12412–12422 (2021). https://doi.org/10.1007/s10853-021-06097-5

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