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Fast-dissolving carvacrol/cyclodextrin inclusion complex electrospun fibers with enhanced thermal stability, water solubility, and antioxidant activity

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Abstract

Carvacrol is a known antioxidant molecule and commonly used in food and cosmetics as a flavor and fragrance agent; however, carvacrol has major issues such as high volatility, low water solubility, and stability. In this study, carvacrol/cyclodextrin inclusion complex fibers (carvacrol/CD-IC fibers) were produced via electrospinning in order to enhance thermal stability, water solubility and shelf-life of carvacrol having antioxidant activity. The phase solubility and computational modeling studies showed that carvacrol can form inclusion complexes with two types of modified CDs, hydroxypropyl-β-cyclodextrin (HPβCD) and hydroxypropyl-γ-cyclodextrin (HPγCD). The carvacrol/cyclodextrin inclusion complex electrospun fibers (carvacrol/HPβCD-IC fibers and carvacrol/HPγCD-IC fibers) were obtained as free-standing fibrous webs. Although pure carvacrol is highly volatile, the electrospun carvacrol/CD-IC fibers were quite effective to preserve high amount of carvacrol due to the inclusion complexation. In addition, carvacrol/CD-IC fibers have shown higher temperature stability for carvacrol. Moreover, carvacrol/CD-IC fibers showed more effective antioxidant activity as compared to pure carvacrol. The carvacrol/CD-IC fibrous webs have shown fast-dissolving character in water due to the enhanced water solubility of carvacrol/CD-IC and their ultrafine fiber structure. In short, encapsulation of carvacrol in electrospun CD-IC fibrous webs has shown potentials for food and oral care applications due to free-standing and fast-dissolving character along with high water solubility, high temperature stability and enhanced antioxidant by carvacrol/cyclodextrin inclusion complexation.

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Acknowledgements

Dr. Uyar acknowledges The Scientific and Technological Research Council of Turkey (TUBITAK), Turkey (Project #213M185) for funding this research. Z. I. Yildiz thanks to TUBITAK-BIDEB for the PhD scholarship. Dr. Durgun acknowledges the support from the Turkish Academy of Sciences—Outstanding Young Scientists Award Program (TUBA-GEBIP)—Turkey.

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Authors and Affiliations

  1. Institute of Materials Science and Nanotechnology, UNAM-National Nanotechnology Research Center, Bilkent University, 06800, Ankara, Turkey

    Zehra I. Yildiz, Asli Celebioglu, Mehmet E. Kilic, Engin Durgun & Tamer Uyar

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  1. Zehra I. Yildiz
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  2. Asli Celebioglu
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  3. Mehmet E. Kilic
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  4. Engin Durgun
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  5. Tamer Uyar
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Correspondence to Tamer Uyar.

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Yildiz, Z.I., Celebioglu, A., Kilic, M.E. et al. Fast-dissolving carvacrol/cyclodextrin inclusion complex electrospun fibers with enhanced thermal stability, water solubility, and antioxidant activity. J Mater Sci 53, 15837–15849 (2018). https://doi.org/10.1007/s10853-018-2750-1

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