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Effective poly(ethylene glycol) methyl ether grafting technique onto Nylon 6 surface to achieve resistance against pathogenic bacteria Staphylococcus aureus and Pseudomonas aeruginosa

  • Biomaterials
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Abstract

Our study is focused on an efficient reduction of amide functional groups to secondary amine on Nylon 6 surface with borane–tetrahydrofuran (BH3–THF) complex, followed by N-alkylation with benzyl chloride (C6H5CH2Cl) which has been successfully used as a model system for further grafting of the reduced Nylon 6 surface by poly(ethylene glycol) methyl ether tosylate (Me-PEG-OTs). The amine-activated surface has been obtained by treatment of reduced Nylon 6 with n-butyllithium or tert-butyllithium in THF. Modified Nylon 6 has been found to be antibacterial particularly due to the presence of hydrophilic poly(ethylene glycol) methyl ether (H3C-PEG) chains. The surface modifications were successfully characterized by various techniques. Water contact angle and free surface energy analyses indicated a significant change in the surface morphology. It was further supported by scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy and Raman spectroscopy. Finally, antibacterial tests were performed against two pathogenic bacterial strains Pseudomonas aeruginosa (CCM 3955) and Staphylococcus aureus (CCM 3953).

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Acknowledgements

This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic and the European Union—European Structural and Investment Funds in the frames of Operational Programme Research, Development and Education—project Hybrid Materials for Hierarchical Structures (HyHi, Reg. No. CZ.02.1.01/0.0/0.0/16_019/0000843), the OPR&DI project “Extension of CxI facilities” (CZ.1.05/2.1.00/19.0386) and the project SGS 21207, Faculty of Science, Humanities and Education, Technical University of Liberec.

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Authors and Affiliations

  1. Department of New Technologies and Applied Informatics, Faculty of Mechatronics, Informatics and Interdisciplinary Studies, Technical University of Liberec, Studentská 1402/2, 46117, Liberec 1, Czech Republic

    Sumita Swar

  2. Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Bendlova 1409/7, 46001, Liberec 1, Czech Republic

    Veronika Zajícová, Jana Müllerová, Petra Šubrtová, Michal Řezanka & Ivan Stibor

  3. Department of Chemistry, Faculty of Science, Humanities and Education, Technical University of Liberec, Studentská 1402/2, 46117, Liberec 1, Czech Republic

    Veronika Zajícová, Jana Müllerová, Michal Řezanka & Ivan Stibor

  4. Department of Nonwovens and Nanofibrous Materials, Faculty of Textile Engineering, University of Liberec, Studentská 1402/2, 46117, Liberec 1, Czech Republic

    Jana Horáková

  5. Department of Analytical Chemistry, University of Chemistry and Technology, Technická 5, 166 28, Prague, Czech Republic

    Bohumil Dolenský

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  1. Sumita Swar
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Swar, S., Zajícová, V., Müllerová, J. et al. Effective poly(ethylene glycol) methyl ether grafting technique onto Nylon 6 surface to achieve resistance against pathogenic bacteria Staphylococcus aureus and Pseudomonas aeruginosa. J Mater Sci 53, 14104–14120 (2018). https://doi.org/10.1007/s10853-018-2636-2

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