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Tuning mesoporous silica dissolution in physiological environments: a review

  • In Honor of Larry Hench
  • Published:
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Abstract

Matrix degradation has a major impact on the release kinetics of drug delivery systems. Regarding ordered mesoporous silica materials for biomedical applications, their dissolution is an important parameter that should be taken into consideration. In this paper, we review the main factors that govern the mesoporous silica dissolution in physiological environments. We also provide the necessary knowledge to researchers in the area for tuning the dissolution rate of those matrices, so the degradation could be controlled and the material behaviour optimised.

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Acknowledgements

The authors thank funding from the EU H2020-NMP-PILOTS-2015 programme through the Grant No. 685872 (MOZART) and the European Research Council (Advanced Grant VERDI; ERC-2015-AdG Proposal No. 694160). The authors also thank Spanish MINECO (CSO2010-11384-E and MAT2015-64831-R Grants). JL Paris gratefully acknowledges MINECO, Spain, for his PhD Grant (BES-2013-064182).

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Authors and Affiliations

  1. Dpto. Química Inorgánica y Bioinorgánica, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040, Madrid, Spain

    Juan L. Paris, Montserrat Colilla, Isabel Izquierdo-Barba, Miguel Manzano & María Vallet-Regí

  2. CIBER de Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, Madrid, Spain

    Juan L. Paris, Montserrat Colilla, Isabel Izquierdo-Barba, Miguel Manzano & María Vallet-Regí

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  1. Juan L. Paris
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  2. Montserrat Colilla
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  3. Isabel Izquierdo-Barba
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  4. Miguel Manzano
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  5. María Vallet-Regí
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Correspondence to María Vallet-Regí.

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Paris, J.L., Colilla, M., Izquierdo-Barba, I. et al. Tuning mesoporous silica dissolution in physiological environments: a review. J Mater Sci 52, 8761–8771 (2017). https://doi.org/10.1007/s10853-017-0787-1

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  • DOI: https://doi.org/10.1007/s10853-017-0787-1

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