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Fast-dissolving sweet sedative nanofiber membranes

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Abstract

The present study reports a new type of sedative nanofiber membranes that were developed to permit very rapid oral delivery of helicid with concomitant taste masking. A coaxial electrospinning process was exploited to prepare core–shell nanofibers and to control the spatial depositions of different functional components. A series of tests was undertaken to characterize the resultant nanofibers. Following optimization of the electrospinning parameters, two types of core–shell nanofibers with average diameters of 730 ± 140 and 770 ± 160 nm were successfully prepared. These had uniform linear morphologies and clear core–shell structures, as verified by scanning and transmission electron microscopy images. The fibers contained sucralose in the shell and helicid in the core; X-ray diffraction demonstrated that both functional components were present in the amorphous physical form. There is significant hydrogen bonding between the functional components and the poly(vinylpyrrolidone) used as the carrier matrix, as shown from Fourier transform infrared spectroscopy and molecular mechanics simulations. In vitro dissolution tests showed that the formulations were able to release the entire incorporated drug extremely rapidly (within 1 min) when they encountered a dissolution medium, whereas the commercially available product released only 13.4 % of its drug loading in the same time. By tailoring the distribution of functional ingredients in electrospun core–shell structures, new drug delivery systems which can both accelerate dissolution and also mask unpleasant tastes were produced.

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References

  1. Mitragotri S, Burke PA, Langer R (2014) Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies. Nat Rev Drug Discov 13:655–672

    Article  Google Scholar 

  2. GohY F, Shakir I, Hussain R (2013) Electrospun fibers for tissue engineering, drug delivery, and wound dressing. J Mater Sci 48:3027–3054. doi:10.1007/s10853-013-7145-8

    Article  Google Scholar 

  3. Yan J, White K, Yu DG, Zhao XY (2014) Sustained release multiple-component cellulose acetate nanofibers fabricated using a modified coaxial electrospinning process. J Mater Sci 49:538–547. doi:10.1007/s10853-013-7733-7

    Article  Google Scholar 

  4. Li C, Wang ZH, Yu DG, Williams GR (2014) Tunable biphasic drug release from ethyl cellulose nanofibers fabricated using a modified coaxial electrospinning process. Nanoscale Res Lett 9:258 10.1007/s10853-013-7733-7

    Article  Google Scholar 

  5. Li C, Yu DG, Williams GR, Wang ZH (2014) Fast-dissolving core-shell composite microparticles of quercetin fabricated using a coaxial electrospray process. PLoS One 9:92106

    Article  Google Scholar 

  6. Liu ZP, Cui L, Yu DG, Zhao ZX, Chen L (2014) Electrosprayed core-shell solid dispersions of acyclovir fabricated using an epoxy-coated concentric spray head. Int J Nanomed 9:1967–1977

    Google Scholar 

  7. Nagy ZK, Balogh A, Drávavölgyi G, Ferguson J, Pataki H, Vajna B, Marosi G (2013) Solvent-free melt electrospinning for preparation of fast dissolving drug delivery system and comparison with solvent-based electrospun and melt extruded systems. J Pharm Sci 102:508–517

    Article  Google Scholar 

  8. Yu DG, Williams GR, Wang X, Liu XK, Li HL, Bligh SWA (2013) Dual drug release nanocomposites prepared using a combination of electrospraying and electrospinning. RSC Adv 3:4652–4658

    Article  Google Scholar 

  9. Bikiaris DN (2011) Solid dispersions, part II: new strategies in manufacturing methods for dissolution rate enhancement of poorly water-soluble drugs. Expert Opin Drug Deliv 8:1663–1680

    Article  Google Scholar 

  10. Yu DG, Yang JM, Branford-White C, Lu P, Zhang L, Zhu LM (2010) Third generation solid dispersions of ferulic acid in electrospun composite nanofibers. Int J Pharm 400:158–164

    Article  Google Scholar 

  11. Yu DG, Zhu LM, Branford-White C, Yang JH, Wang X, Li Y, Qian W (2011) Solid dispersions in the form of electrospun core-sheath nanofibers. Int J Nanomed 6:3271–3280

    Article  Google Scholar 

  12. Thien DVH, Hsiao SW, Ho MH, Li CH, Shih JL (2013) Electrospun chitosan/hydroxyapatite nanofibers for bone tissue engineering. J Mater Sci 48:1640–1645. doi:10.1007/s10853-012-6921-1

    Article  Google Scholar 

  13. Zahedi P, Rezaeian I, Jafari S, Hassan R (2013) In vitro and in vivo evaluation of phenyton sodium-loaded electrospun PVA, PCL and their hybrid nanofibrous mats for use as active wound dressing. J Mater Sci 48:3147–3159. doi:10.1007/s10853-012-7092-9

    Article  Google Scholar 

  14. Nguyen TTT, Ghosh C, Hwang SG, Tran LD, Park JS (2013) Characteristics of curcumin-loaded poly (lactic acid) nanofibers for wound healing. J Mater Sci 48:7125–7133 10.1007/s10853-013-7527-y

    Article  Google Scholar 

  15. Vasconcelos T, Sarmento B, Costa P (2007) Solid dispersions as strategy to improve oral bioavailability of poor water-soluble drugs. Drug Discov Today 12:1068–1075

    Article  Google Scholar 

  16. Farokhzad OC (2008) Nanotechnology for drug delivery: the perfect partnership. Expert Opin Drug Deliv 5:927–929

    Article  Google Scholar 

  17. Yan J, Wu YH, Yu DG, Williams GR, Huang SM, Tao W, Sun JY (2014) Electrospun acid–base pair solid dispersions of quercetin. RSC Adv 4:58265–58271

    Article  Google Scholar 

  18. Venkataraman S, Hedrick JL, Ong ZY, Yang C, Rachel Ee PL, Hammond PT, Yang YY (2011) The effects of polymeric nanostructure shape on drug delivery. Adv Drug Deliv Rev 63:1228–1246

    Article  Google Scholar 

  19. Jalani G, Jung CW, Lee JS, Lim DW (2014) Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems. Int J Nanomed 9:33–49

    Google Scholar 

  20. Agarwal S, Greiner A, Wendorff JH (2013) Functional materials by electrospinning of polymers. Prog Polym Sci 38:963–991

    Article  Google Scholar 

  21. Xie J, Liu W, MacEwan MR, Bridgman PC, Xia Y (2014) Neurite outgrowth on electrospun nanofibers with uniaxial alignment: the effects of fiber density, surface coating, and supporting substrate. ACS Nano 8:1878–1885

    Article  Google Scholar 

  22. Lee JA, Nam YS, Rutledge GC, Hammond PT (2010) Enhanced photocatalytic activity using layer-by-layer electrospun constructs for water remediation. Adv Funct Mater 20:2424–2429

    Article  Google Scholar 

  23. Prabhakaran MP, Mobarakeh LG, Kai D, Karbalaie K, Nasr-Esfahani MH, Ramakrishna S (2014) Differentiation of embryonic stem cells to cardiomyocytes on electrospun nanofibrous substrates. J Biomed Mater Res 102B:447–454

    Article  Google Scholar 

  24. Zhang L, Aboagye A, Kelkar A, Lai C, Fang H (2014) A review: carbon nanofibers from electrospun polyacrylonitrile and their applications. J Mater Sci 49:463–480. doi:10.1007/s10853-013-7705-y

    Article  Google Scholar 

  25. Sun B, Long YZ, Zhang HD, Li MM, Duvail JL, Jiang XY, Yin HL (2014) Advances in three-dimensional nanofibrous macrostructures via electrospinning. Prog Polym Sci 39:862–890

    Article  Google Scholar 

  26. Jung CW, Jalani G, Ko J, Choo J, Lim DW (2014) Synthesis, characterization, and directional binding of anisotropic biohybrid microparticles for multiplexed biosensing. Macromol Rapid Commun 35:56–65

    Article  Google Scholar 

  27. Yu DG, Yu JH, Chen L, Williams GR, Wang X (2012) Modified coaxial electrospinning for the preparation of high-quality ketoprofen-loaded cellulose acetate nanofibers. Carbohydr Polym 90:1016–1023

    Article  Google Scholar 

  28. Liang X, Li J, Joo JB, Gutiérrez A, Tillekaratne A, Lee I, Yin Y, Zaera F (2012) Diffusion through the shells of yolk–shell and core–shell nanostructures in the liquid phase. Angew Chem Int Ed 51:8034–8036

    Article  Google Scholar 

  29. Hu X, Liu S, Zhou G, Huang Y, Xie Z, Jing X (2014) Electrospinning of polymeric nanofibers for drug delivery applications. J Control Release 185:12–21

    Article  Google Scholar 

  30. Jiang H, Wang L, Zhu K (2014) Coaxial electrospinning for encapsulation and controlled release of fragile water-soluble bioactive agents. J Control Release 193:296–303

    Article  Google Scholar 

  31. Zhang CL, Yu SH (2014) Nanoparticles meet electrospinning: recent advanced and future prospects. Chem Soc Rev 43:4423–4448

    Article  Google Scholar 

  32. Chaudhuri RG, Paria S (2012) Core/shell nanoparticles: classes, properties, synthesis mechanisms, characterization, and applications. Chem Rev 112:2373–2433

    Article  Google Scholar 

  33. Brettmann B, Bell E, Myerson A, Trout B (2012) Solid-state NMR characterization of high-loading solid solutions of API and excipients formed by electrospinning. J Pharm Sci 101:1538–1545

    Article  Google Scholar 

  34. Balogh A, Drávavölgyi G, Faragó K, Farkas A, Vigh T, Sóti PL, Wagner I, Madarász J, Pataki H, Marosi G, Nagy ZK (2014) Plasticized drug-loaded melt electrospun polymer mats: characterization, thermal degradation, and release kinetics. J Pharm Sci 103:1278–1287

    Article  Google Scholar 

  35. Brettmann BK, Cheng K, Myerson AS, Trout BL (2013) Electrospun formulations containing crystalline active pharmaceutical ingredients. Pharm Res 301:238–246

    Article  Google Scholar 

  36. Vigh T, Horvathova T, Balogh A, Sóti PL, Drávavölgyi G, Nagy ZK, Marosi G (2013) Polymer-free and polyvinylpirrolidone-based electrospun solid dosage forms for drug dissolution enhancement. Eur J Pharm Sci 49:595–602

    Article  Google Scholar 

  37. Yu DG, Gao LD, White K, Brandford-White C, Lu WY, Zhu LM (2010) Multicomponent amorphous nanofibers electrospun from hot aqueous solutions of a poorly soluble drug. Pharm Res 27:2466–2477

    Article  Google Scholar 

  38. Yuan Z, Zhou X, Yang X (2006) The preparation of oral fast-disintegrating helicid tablets. Chin J Pharm 37:99–100

    Google Scholar 

  39. Dott C, Tyagi C, Tomar LK, Choonara YE, Kumar P, Toit LC, Pillay V (2013) J Nanomater 2013:924947

    Article  Google Scholar 

  40. Lu X, Wang C, Wei Y (2009) One-dimensional composite nanomaterials: synthesis by electrospinning and their applications. Small 5:2349–2370

    Article  Google Scholar 

  41. Moghe K, Gupta BS (2008) Co-axial electrospinning for nanofiber structures: preparation and applications. Polym Rev 48:353–377

    Article  Google Scholar 

Download references

Acknowledgements

This study was supported by the Training Project for Excellent Young and Middle-aged Backbone teachers of Higher Schools in Guangxi province, the National Science Foundation of China (Nos. 51373101 and 5140030478), the China NSFC/UK Royal Society Cost Share International Exchanges Scheme (No.51411130128/IE131748), the Natural Science Foundation of Shanghai (Nos. 13ZR1428900), and the Key Project of the Shanghai Municipal Education Commission (No. 13ZZ113).

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Authors and Affiliations

  1. The Department of Mechanical Engineering, Guangxi Technological College of Machinery and Electricity, Nanning, 530007, People’s Republic of China

    Yong-Hui Wu

  2. School of Materials Science & Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Yangpu District, Shanghai, 200093, People’s Republic of China

    Deng-Guang Yu, Xiao-Yan Li, Ai-Hua Diao & Gareth R. Williams

  3. The Department of Business Administration, Guangxi Technological College of Machinery and Electricity, Nanning, 530007, People’s Republic of China

    Ai-Hua Diao

  4. UCL School of Pharmacy, University College London, London, WC1N 1AX, UK

    Upulitha Eranka Illangakoon & Gareth R. Williams

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  1. Yong-Hui Wu
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  2. Deng-Guang Yu
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Correspondence to Deng-Guang Yu, Ai-Hua Diao or Gareth R. Williams.

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Wu, YH., Yu, DG., Li, XY. et al. Fast-dissolving sweet sedative nanofiber membranes. J Mater Sci 50, 3604–3613 (2015). https://doi.org/10.1007/s10853-015-8921-4

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  • DOI: https://doi.org/10.1007/s10853-015-8921-4

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