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Retention of a plethora of essential oils and aromas in deep eutectic solvent:water:cyclodextrin mixtures

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Abstract

Essential oils (EOs) and aromas have long been used in the perfume, cosmetic, pharmaceutical and food industries. Yet, aside their poor solubility and instability, their high volatility limits their application. Their encapsulation in cyclodextrins (CDs) or their solvation in deep eutectic solvents (DESs) are two efficient strategies to resolve such problems. Thus, the present study aims to investigate the retention ability of the combination of DESs and CDs towards a wide variety of EOs and aromas. Thus, the capacity of formulations combining choline chloride:urea (ChCl:U) DES, CDs and water to retain and decrease the volatility of twenty EOs and twenty-one aromas was examined. Also, the formation constants (Kf) of CD/aroma inclusion complexes in this new non-conventional medium were determined. Results showed that ChCl:U DES:water 70:30 wt% mixed with 10 wt% CD had an efficient ability to retain all the studied EOs and aromas. Also, the addition of CDs in this mixture was shown to be advantageous in improving the efficiency of the formulation even if lower complexation ability towards the aromas was observed compared to water. Altogether, the obtained results will encourage the use of DES:water:CD mixtures for the incorporation of EOs and aromas in different preparations.

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Acknowledgements

The authors would like to acknowledge the National Council for Scientific Research of Lebanon (CNRS-L) and Université du Littoral Côte d'Opale (ULCO) for granting a doctoral fellowship to Lamia Nakhle. This work is a contribution to the CPER (Contrat de Plan Etat-Région) research project IRenE (Innovation et Recherche en Environnement) and is supported by the Ministère de l’Enseignement Supérieur (France), the region Hauts-de-France and the European Regional Development Fund.

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Authors and Affiliations

  1. Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV, UR 4492), Université du Littoral Côte d’Opale (ULCO), 145 Av. M. Schumann, 59140, Dunkirk, France

    Lamia Nakhle, Miriana Kfoury & David Landy

  2. Bioactive Molecules Research Laboratory, Faculty of Sciences, Lebanese University, Jdeidet el-Metn, 90656, Lebanon

    Lamia Nakhle & Hélène Greige-Gerges

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  1. Lamia Nakhle
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  2. Miriana Kfoury
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L.N. prepared all figures and tables. L.N and M.K. wrote the main manuscript. All authors reviewed the main manuscript.

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Correspondence to Miriana Kfoury.

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Nakhle, L., Kfoury, M., Greige-Gerges, H. et al. Retention of a plethora of essential oils and aromas in deep eutectic solvent:water:cyclodextrin mixtures. J Incl Phenom Macrocycl Chem 103, 35–44 (2023). https://doi.org/10.1007/s10847-022-01174-x

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