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The effect of phosphate buffer solutions on uniconazole complexation with hydroxypropyl-β-cyclodextrin and methyl-β-cyclodextrin

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Abstract

The inclusion complexes of uniconazole [(E)-1-(4-chlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-lyl)-1-penten-3-ol, UCZ] with two cyclodextrin derivatives, hydroxypropyl-β-cyclodextrin (HP-β-CD) and methylated-β-cyclodextrin (Me-β-CD), were prepared and characterized by 1H NMR and FT-IR. The phase solubility of UCZ and HP-β-CD, UCZ and Me-β-CD, which displays the ability of CDs complexation and solubilization, was studied in aqueous solutions and phosphate buffer solutions (PBS) with different property pH values (6.2, 7.2, 8.0). The solubility results indicated that the pH of PBS showed more enhancement on the interaction of HP-β-CD and UCZ than Me-β-CD with the increasing pH value, and the optimal pH value for complexation of UCZ and HP-β-CD, UCZ and Me-β-CD was at 8.0 and at 7.2, respectively. These were also determined by UCZ release behavior and dissolution studies of the complexes in solid state.

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Acknowledgments

The authors acknowledge the support of the National High Technology Research and Development Program of China (No. 2011AA10A206) and Transformation Fund for Agricultural Science and Technology Achievements of China (No. 2008GB23600451).

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Authors and Affiliations

  1. Engineering Research Center of Plant Growth Regulator, Ministry of Education, College of Agronomy and Biotechnology, China Agricultural University, Beijing, 100193, People’s Republic of China

    Xiaofeng Zhu, Weiming Tan, Fan Zhou, Zhaohu Li & Liusheng Duan

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  1. Xiaofeng Zhu
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  2. Weiming Tan
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  3. Fan Zhou
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  4. Zhaohu Li
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  5. Liusheng Duan
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Correspondence to Liusheng Duan.

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The first two authors contributed equally to this work.

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Zhu, X., Tan, W., Zhou, F. et al. The effect of phosphate buffer solutions on uniconazole complexation with hydroxypropyl-β-cyclodextrin and methyl-β-cyclodextrin. J Incl Phenom Macrocycl Chem 73, 193–198 (2012). https://doi.org/10.1007/s10847-011-0042-3

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  • DOI: https://doi.org/10.1007/s10847-011-0042-3

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