Skip to main content
SpringerLink
Log in

Solvent extraction of dopamine by heptakis (2,3,6-tri-O-acetyl)-β-cyclodextrin

  • Original Article
  • Published:
Journal of Inclusion Phenomena and Macrocyclic Chemistry Aims and scope Submit manuscript

Abstract

The possibility of modified cyclodextrin, heptakis (2,3,6-tri-O-acetyl)-β-cyclodextrin (TA-β-CD) to act as extracting agent for dopamine from aqueous phase into the organic phase has been investigated. Thus, by means of an ion-pairing mechanism, dopamine was extracted by modified cyclodextrin in the presence of counter ions such as picrate and tropaeolin 00. The results showed that the modified cyclodextrin can be used as extractant for dopamine. Some aspects of dopamine extractability concerning the pH and the nature of anion used as counter ion have been studied.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Chart 1
Fig. 1

Similar content being viewed by others

References

  1. Zhang, A., Neumeyer, J.L., Baldessarini, R.J.: Recent progress in development of dopamine receptor subtype-selectivity agents: potential therapeutics for neurological and psychiatric disorders. Chem. Rev. 107, 274–302 (2007)

    Article  CAS  Google Scholar 

  2. Maminski, M., Olejniczak, M., Chudy, M., Dybko, A., Brzoka, Z.: Spectrophotometric determination of dopamine in microliter scale using microfluidic system based on polymeric technology. Anal. Chim. Acta 540, 153–157 (2005)

    Article  CAS  Google Scholar 

  3. Yoshizuka, K., Fujimoto, Y., Ohto, K., Inoue, K.: Solvent extraction and QSPR of catecholamines with a bis(2-ethylhexyl) hydrogen phosphate. J. Chem. Eng. Jpn 32, 76–81 (1999)

    Article  CAS  Google Scholar 

  4. Benes, F.M.: Carlsson and the discovery of dopamine. Trends Pharmacol. Sci. 22, 46–47 (2001)

    Article  CAS  Google Scholar 

  5. Morón, J.A., Brockington, A., Wise, R.A., Rocha, B.A., Hope, B.T.: Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. J. Neurosci. 22, 389–395 (2002)

    Google Scholar 

  6. Tsai, Y.F., Tsai, H.W., Tai, M.Y.: Comparison of brain dopamine depletion induced by low-dose 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine (MPTP) in young and aged rats. Neurosci. Res. 20, 27–33 (1994)

    Article  CAS  Google Scholar 

  7. Oshima, T., Oishi, K., Ohto, K., Inoue, K.: Extraction of catecholamines by calixarene carboxylic acid derivatives. J. Incl. Phenom. Macrocycl. Chem. 55, 79–85 (2006)

    Article  CAS  Google Scholar 

  8. Mutihac, L., Mutihac, R., Constantinescu, T., Luca, C.: The transport of amino acids by 18-crown-6 through liquid membranes. J. Incl. Phenom. Mol. Recognit. Chem. 17, 45–51 (1994)

    Article  CAS  Google Scholar 

  9. Buschmann, H.-J., Schollmeyer, E., Wenz, G., Mutihac, L.: Solvent influence upon complex formation between crown ethers and unprotonated amines. Thermochim. Acta 261, 1–5 (1995)

    Article  CAS  Google Scholar 

  10. Másson, M.J., Karlsson, F., Valdimarsdóttir, M., Magnúsdóttir, K., Loftsson, T.: Cyclodextrins and the liquid–liquid phase distribution of progesterone, estrone and prednicarbate. J. Incl. Phenom. Macrocycl. Chem. 57, 481–487 (2007)

    Article  Google Scholar 

  11. Buschmann, H.-J., Mutihac, R.-C., Schollmeyer, E.: Interactions between crown crown ethers and water, methanol, acetone, and acetonitrile in halogenated solvents. J. Solut. Chem. 39, 291–299 (2010)

    Article  CAS  Google Scholar 

  12. Szejtli, J., Osa, T.: Comprehensive Supramolecular Chemistry, vol. 3: Cyclodextrins. Pergamon Press, Oxford (1996)

  13. Mutihac, R.-C., Buschmann, H.-J., Schollmeyer, E.: Influence of polar solvents upon the complex formation of 18-crown-6 with cations in chloroform. J. Incl. Phenom. Macrocycl. Chem. 68, 411–416 (2010)

    Article  CAS  Google Scholar 

  14. Mutihac, L., Lee, J.H., Kim, J.S., Vicens, J.: Recognition of amino acids by functionalized calixarenes. Chem. Soc. Rev. 40, 2777–2796 (2011)

    Article  CAS  Google Scholar 

  15. Nepogodiev, S.A., Stoddart, J.F.: Cyclodextrin-based catenenes and rotaxanes. Chem. Rev. 98, 1959–1976 (1998)

    Article  CAS  Google Scholar 

  16. Dodziuk, H.: Cyclodextrins and their Complexes. Chemistry Analytical Methods, Applications. Wiley-VCH, Weinheim (2006)

    Book  Google Scholar 

  17. Kim, L., Stancu, A.D., Diacu, E., Buchmann, H.J., Mutihac, L.: Extraction and transport behaviour of aromatic amino acids by modified cyclodextrins. Supramol. Chem. 21, 131–134 (2009)

    Article  CAS  Google Scholar 

  18. Marcus, Y.: Ion Solvation. Wiley, Chichester (1985)

    Google Scholar 

  19. Pedersen, C.J.: Ionic complexes of macrocyclic polyethers. J. Fed. Proc. Fed. Am. Soc. Exp. Biol. 27, 1305–1309 (1968)

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu 1, 011061, Bucharest, Romania

    Elena Diacu, Elena Ruse & Madalin Marin Ceausescu

  2. Department of Analytical Chemistry, University of Bucharest, 4-12, Blvd. Regina Elisabeta, 030018, Bucharest, Romania

    Lucia Mutihac

Authors
  1. Elena Diacu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lucia Mutihac
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Elena Ruse
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Madalin Marin Ceausescu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Elena Diacu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Diacu, E., Mutihac, L., Ruse, E. et al. Solvent extraction of dopamine by heptakis (2,3,6-tri-O-acetyl)-β-cyclodextrin. J Incl Phenom Macrocycl Chem 71, 339–342 (2011). https://doi.org/10.1007/s10847-011-0004-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10847-011-0004-9

Keywords

Search

Navigation