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DNA cleavage and antimicrobial studies of 17-membered schiff base macrocyclic triazoles: synthesis and spectroscopic approach

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Abstract

A novel series of 17-membered complexes [MLCl2] (M = Co2+, Ni2+ and Cu2+) have been synthesized with newly derived biologically active ligands (LI–LIV). These ligands were synthesized by the condensation of 3-subtituted-4-amino-5-hydrazino-1,2,4-triazole with bis(phthalaldehyde)ethylenediamine precursor. The structure of the complexes has been proposed by elemental analyses, IR, EPR, electronic spectral studies, conductivity, magnetic, thermal and electrochemical studies. All the complexes are soluble in DMF and DMSO and are non-electrolytes. All these Schiff bases and their complexes have been screened for their antibacterial (Escherichia coli, Staphylococus aureus, Salmonella typhi, Pseudomonas aeruginosa) and antifungal activities (Aspergillus niger, Aspergillus flavus and Cladosporium) by the Agar and Potato dextrose agar diffusion method. The DNA cleavage study was done by Agarose gel electrophoresis technique.

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Abbreviations

BM:

Bohr Magneton

EPR:

Electron paramagnetic resonance

FAB:

Fast atom bombardment

TG/DTG:

Thermogravimetric/differential thermogravimetric analysis

DMF:

N,N dimethyl formamide

DMSO:

Dimethylsulphoxide

IR:

Infra red

MIC:

Minimum inhibitory concentration

NMR:

Nuclear magnetic resonance

MRI:

Magnetic resonance imaging

TMS:

Tetramethylsilane

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Acknowledgements

The authors are grateful to the Chairman, Department of Chemistry, Karnatak University, Dharwad for the facilities. One of the authors (UVK) grateful to the University Grant Commission, New Delhi for grant of Research Fellowship in Science for Meritorious Students.

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Authors and Affiliations

  1. P.G. Department of Chemistry, Karnatak University, Dharwad, 580003, Karnataka, India

    Udaykumar V. Kamble & Sangamesh A. Patil

  2. Department of Chemistry, Shri Sharanabasaveshwar College of Science, Gulbarga, 585 102, Karnataka, India

    Prema S. Badami

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  1. Udaykumar V. Kamble
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  2. Sangamesh A. Patil
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  3. Prema S. Badami
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Correspondence to Sangamesh A. Patil.

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Kamble, U.V., Patil, S.A. & Badami, P.S. DNA cleavage and antimicrobial studies of 17-membered schiff base macrocyclic triazoles: synthesis and spectroscopic approach. J Incl Phenom Macrocycl Chem 68, 347–358 (2010). https://doi.org/10.1007/s10847-010-9794-4

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