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Host–guest complexes of docetaxel, an anti-cancer drug

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Abstract

Host–guest complexes of Docetaxel 1, an anti-cancer drug have been isolated and crystal structures are described. Docetaxel crystallized in the 1:1 molar ratio with n-butanol, dimethylformamide (DMF) and acetonitrile (ACN) during crystallization from the respective solvents. In all the three complexes (1 · n-butanol, 1 · DMF and 1 · ACN), docetaxel formed a host framework through hydrogen bonds and the guest solvent molecules occupied the channels. The host is hydrogen bonded to the guest molecules through hydroxyl moieties. Interestingly, 1 · n-butanol, 1 · DMF and a literature 1 · CH3OH · H2O (1:1:1) host–guest complexes are isomorphs. Further, 1 · ACN complex unit cell parameters are similar (same space group) to the marketed docetaxel trihydrate polymorph (form A).

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Acknowledgements

We are grateful to the Dr. Reddy’s Discovery Research for the encouragement. We thank Mr. B. R. Sreekanth for 1 · ACN crystal structure refinement.

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Authors and Affiliations

  1. Department of Analytical Research, Discovery Research, Dr. Reddy’s Laboratories Ltd., Miyapur, Hyderabad, 500049, India

    T. Lakshmi Kumar, Pooja Guleria, Peddy Vishweshwar, A. Sivalakshmidevi & J. Moses Babu

  2. Analytical Research and Development, Integrated Product Development, Dr. Reddy’s Laboratories Ltd., Bachupalli, Hyderabad, 500072, India

    K. Vyas

  3. Research & Development, Integrated Product Development, Dr. Reddy’s Laboratories Ltd., Bachupalli, Hyderabad, 500072, India

    Palle V. R. Acharyulu, N. M. Sekhar & B. Selva Kumar

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  1. T. Lakshmi Kumar
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Correspondence to Peddy Vishweshwar.

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Lakshmi Kumar, T., Guleria, P., Vishweshwar, P. et al. Host–guest complexes of docetaxel, an anti-cancer drug. J Incl Phenom Macrocycl Chem 66, 261–269 (2010). https://doi.org/10.1007/s10847-009-9606-x

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  • DOI: https://doi.org/10.1007/s10847-009-9606-x

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