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Formation of Cyclodextrin Inclusion Complexes with Doxycyclin-Hyclate: NMR Investigation of Their Characterisation and Stability

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Abstract

The solubility of cyclodextrin (CD) can be notably improved when it is included in a polymeric structure. CD was reacted with citric acid, yielding a water-soluble polymer whose inclusion properties towards doxycyclin-hyclate (DOX) as guest molecule were investigated by NMR. The new DOSY (Diffusion Ordered SpectroscopY) method, based on diffusion coefficient measurements is convenient study complexes made of large molecules and it was applied to determine the association constants between DOX and parent β and γ-CD and their polymerised forms. The association constant obtained by DOSY was compared with that determined more classically by the chemical shift variation measurement using Scott's plot.

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Authors and Affiliations

  1. Laboratoire de Physique, UMR CNRS 8009, Faculté des Sciences Pharmaceutiques et Biologiques, BP83, 59006, Lille, France

    Youssef Bakkour, Gaston Vermeersch & Nathalie Azaroual

  2. Laboratoire de Chimie Organique et Macromoléculaire, UMR CNRS 8009, Université des Sciences et Technologie de Lille 1, 59655, Villeneuve d' Ascq, Cedex, France

    Michel Morcellet, FranÇois Boschin & Bernard Martel

Authors
  1. Youssef Bakkour
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  2. Gaston Vermeersch
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  3. Michel Morcellet
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  4. FranÇois Boschin
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  5. Bernard Martel
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  6. Nathalie Azaroual
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Correspondence to Nathalie Azaroual.

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Bakkour, Y., Vermeersch, G., Morcellet, M. et al. Formation of Cyclodextrin Inclusion Complexes with Doxycyclin-Hyclate: NMR Investigation of Their Characterisation and Stability. J Incl Phenom Macrocycl Chem 54, 109–114 (2006). https://doi.org/10.1007/s10847-005-5108-7

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  • DOI: https://doi.org/10.1007/s10847-005-5108-7

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