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Inclusion Complexes of Manidipine with γ-Cyclodextrin and Identification of Photodegradation Products

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Abstract

The paper presents results of a study of photochemical decomposition of manidipine and its inclusion complexes with γ-cyclodextrin and identification of photodegradation products. The process was qualitatively assessed by the UV spectrophotometry and by HPLC-MS. The quantitative assessment of its efficiency was performed on the basis of kinetic parameters and quantum yields. The main product of photodegradation was nitrophenylpyridine derivative, while the concentration of nitrozophenylpyridine derivative being the other product of this process, was about 20 times lower. The inclusion complexes of manidipine with γ-cyclodextrin were obtained in the liquid phase. The stoichiometry of the complexes was determined from the Benesi–Hildebrand equation. The photochemical stability of manidipine in inclusion complexes was compared with that of manidipine in non-complexed form.

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Authors and Affiliations

  1. Department Inorganic and Analytical Chemistry, K. Marcinkowski University of Medical Sciences, Grunwaldzka 6, 60-780, Poznań, Poland

    Jadwiga Mielcarek & Olga Szamburska

Authors
  1. Jadwiga Mielcarek
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  2. Olga Szamburska
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Correspondence to Jadwiga Mielcarek.

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Mielcarek, J., Szamburska, O. Inclusion Complexes of Manidipine with γ-Cyclodextrin and Identification of Photodegradation Products. J Incl Phenom Macrocycl Chem 52, 195–200 (2005). https://doi.org/10.1007/s10847-004-6975-z

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  • DOI: https://doi.org/10.1007/s10847-004-6975-z

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