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Interactions of Nabumetone with γ-Cyclodextrin Studied by Fluorescence Measurements

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Abstract

The inclusion of the anti-inflammatory drug, Nabumetone (NAB), in γ-cyclodextrin (γ-CD) was studied by fluorescence measurements. The emission fluorescence spectrum, of NAB reveals a maximum whose intensity increases with the different γ-CD’s growing concentrations. The stoichiometery (1:1) and binding constants of the complexes at 15, 25, 35, and 45 °C were extracted from the analysis of the emission spectra of NAB. The thermodynamic parameters ΔH ° and ΔS ° for the formation of the complex were calculated from the temperature dependence of the binding constants and compared with previous results for similar complexes of NAB with α- and β-CDs. The location of NAB in the complex was determined using the fluorescence quenching method. Our results indicate that NAB is completely penetrated into the cavity of γ-CD.

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  1. Department of Chemistry, Jordan University of Science and Technology, P. O. Box 3030, Irbid, 22110, Jordan

    Nathir A. F. Al-Rawashdeh

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  1. Nathir A. F. Al-Rawashdeh
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Correspondence to Nathir A. F. Al-Rawashdeh.

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Al-Rawashdeh, N.A.F. Interactions of Nabumetone with γ-Cyclodextrin Studied by Fluorescence Measurements. J Incl Phenom Macrocycl Chem 51, 27–32 (2005). https://doi.org/10.1007/s10847-004-1502-9

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  • DOI: https://doi.org/10.1007/s10847-004-1502-9

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