Abstract
Background
While ICD therapy reduction programming strategies are recommended in current multi-society guidelines, concerns remain about a possible trade-off between the benefits of ICD therapy reduction and failure to treat episodes of ventricular arrhythmias. The study is to evaluate the outcomes of primary prevention patients followed in centers with high and low concordance with the 2015 HRS/EHRA/APHRS/SOLAECE expert consensus statement and 2019 focused update on optimal ICD programming and testing guidelines.
Methods
Consecutive patients with primary prevention ICD implantation from two centers between 2014 and 2016 were included. One center was classified as high guideline concordance center (HGC) with 47% (146/310) of patients with initial ICD concordant with the guidelines, and the other center was classified as low guideline concordance center (LGC) with only 1% (2/178) of patients with guideline-concordant initial ICD programming. Cox proportional hazard models were used to assess risk of first ICD therapy (ATP or shock), first ICD shock, and mortality.
Results
A total of 488 patients were included (mean age, 66 ± 13 years). During a mean follow-up of 1.9 ± 0.9 years, patients followed at HGC were 63% less likely to receive any ICD therapy (adjusted HR [aHR] 0.37, 95% CI 0.42–0.99). There were no significant differences in the rate of first ICD shock (aHR 0.72, 95% CI 0.34–1.52) or mortality (aHR 1.19, 95% CI, 0.47–3.05).
Conclusions
Compared to primary prevention patients followed at LGC, primary prevention ICD patients followed at HGC received a significantly lower rate of ICD therapy, mainly from ATP reduction, without a difference in mortality during follow-up.
Graphical Abstract
Similar content being viewed by others
Data availability
Data are available on request from the authors.
References
Al-Khatib SM, Stevenson WG, Ackerman MJ, Bryant WJ, Callans DJ, Curtis AB, et al. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Circulation. 2018;138(13):e272–391. https://doi.org/10.1161/CIR.0000000000000549.
Moss AJ, Hall WJ, Cannom DS, Daubert JP, Higgins SL, Klein H, et al. Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. N Engl J Med. 1996;335(26):1933–40. https://doi.org/10.1056/NEJM199612263352601.
Moss AJ, Zareba W, Hall WJ, Klein H, Wilber DJ, Cannom DS, et al. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med. 2002;346(12):877–83. https://doi.org/10.1056/NEJMoa013474.
Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, et al. Amiodarone or an implantable cardioverter–defibrillator for congestive heart failure. N Engl J Med. 2005;352(3):225–37. https://doi.org/10.1056/NEJMoa043399.
Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass DA, De Marco T, et al. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med. 2004;350(21):2140–50. https://doi.org/10.1056/NEJMoa032423.
Wilkoff BL, Fauchier L, Stiles MK, Morillo CA, Al-Khatib SM, Almendral J, et al. 2015 HRS/EHRA/APHRS/SOLAECE expert consensus statement on optimal implantable cardioverter-defibrillator programming and testing. EP Europace. 2015;18(2):159–83. https://doi.org/10.1093/europace/euv411.
Daubert JP, Zareba W, Cannom DS, McNitt S, Rosero SZ, Wang P, et al. Inappropriate implantable cardioverter-defibrillator shocks in MADIT II: frequency, mechanisms, predictors, and survival impact. J Am Coll Cardiol. 2008;51(14):1357–65. https://doi.org/10.1016/j.jacc.2007.09.073.
Iftikhar S, Mattu A, Brady W. ED evaluation and management of implantable cardiac defibrillator electrical shocks. Am J Emerg Med. 2016;34(6):1140–7. https://doi.org/10.1016/j.ajem.2016.02.060.
Ruwald AC, Schuger C, Moss AJ, Kutyifa V, Olshansky B, Greenberg H, et al. Mortality reduction in relation to implantable cardioverter defibrillator programming in the multicenter automatic defibrillator implantation trial-reduce inappropriate therapy (MADIT-RIT). Circulation: Arrhythmia and Electrophysiol. 2014;7(5):785–92. https://doi.org/10.1161/CIRCULATIONAHA.113.004196.
Gasparini M, Proclemer A, Klersy C, Kloppe A, Lunati M, Ferrer JBM, et al. Effect of long-detection interval vs standard-detection interval for implantable cardioverter-defibrillators on antitachycardia pacing and shock delivery: the ADVANCE III randomized clinical trial. JAMA. 2013;309(18):1903–11. https://doi.org/10.1001/jama.2013.4598.
Moss AJ, Schuger C, Beck CA, Brown MW, Cannom DS, Daubert JP, et al. Reduction in inappropriate therapy and mortality through ICD programming. N Engl J Med. 2012;367(24):2275–83. https://doi.org/10.1056/NEJMoa1211107.
Saeed M, NEASON CG, RAZAVI M, CHANDIRAMANI S, ALONSO J, NATARAJAN MS, et al. Programming Antitachycardia pacing for primary prevention in patients with implantable cardioverter defibrillators: results from the PROVE trial. J Cardiovasc Electrophysiol. 2010;21(12):1349–54. https://doi.org/10.1111/j.1540-8167.2010.01825.x.
Wilkoff BL, Williamson BD, Stern RS, Moore SL, Lu F, Lee SW, et al. Strategic programming of detection and therapy parameters in implantable cardioverter-defibrillators reduces shocks in primary prevention patients: results from the PREPARE (primary prevention parameters evaluation) study. J Am Coll Cardiol. 2008;52(7):541–50. https://doi.org/10.1016/j.jacc.2008.05.011.
Gasparini M, Menozzi C, Proclemer A, Landolina M, Iacopino S, Carboni A, et al. A simplified biventricular defibrillator with fixed long detection intervals reduces implantable cardioverter defibrillator (ICD) interventions and heart failure hospitalizations in patients with non-ischaemic cardiomyopathy implanted for primary prevention: the RELEVANT [role of long detection window programming in patients with left ventricular dysfunction, non-ischemic etiology in primary prevention treated with a biventricular ICD] study. Eur Heart J. 2009;30(22):2758–67. https://doi.org/10.1093/eurheartj/ehp247.
Aktas MK, Bennett AL, Younis A, Kutyifa V, Polonsky B, McNitt S, et al. Implantable cardioverter-defibrillator programming after first occurrence of ventricular tachycardia in the multicenter automatic defibrillator implantation trial-reduce inappropriate therapy (MADIT-RIT). Heart Rhythm 02. 2020;1(2):77–82. https://doi.org/10.1016/j.hroo.2020.04.001.
Tan VH, Wilton SB, Kuriachan V, Sumner GL, Exner DV. Impact of programming strategies aimed at reducing nonessential implantable cardioverter defibrillator therapies on mortality. Circ: Arrhythmia Electrophysiol. 2014;7(1):164–70. https://doi.org/10.1161/CIRCEP.113.001217.
Stiles MK, Fauchier L, Morillo CA, Wilkoff BL. 2019 HRS/EHRA/APHRS/LAHRS focused update to 2015 expert consensus statement on optimal implantable cardioverter-defibrillator programming and testing. Heart Rhythm. 2020;17(1):e220–8. https://doi.org/10.1016/j.hrthm.2019.02.034.
Ananwattanasuk T, Tanawuttiwat T, Chokesuwattanaskul R, Lathkar-Pradhan S, Barham W, Oral H, et al. Programming implantable cardioverter–defibrillator in primary prevention: guideline concordance and outcomes. Heart Rhythm. 2020;17(7):1101–6. https://doi.org/10.1016/j.hrthm.2020.02.004.
Sun S, Johnson J, Degroot P, Brown ML, Obel O. Effect of ICD therapies on mortality in the OMNI trial. J Cardiovasc Electrophysiol. 2016;27(2):192–9. https://doi.org/10.1111/jce.12860.
Thøgersen AM, Larsen JM, Johansen JB, Abedin M, Swerdlow CD. Failure to treat life-threatening ventricular tachyarrhythmias in contemporary implantable cardioverter-defibrillators: implications for strategic programming. Circ Arrhythm Electrophysiol. 2017;10(9):e005305. https://doi.org/10.1161/CIRCEP.117.005305.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Ethics approval
This study was approved by the Ethics Committee of the University of Michigan and Michigan State University.
Informed consent
N/A.
Conflict of interest
The authors declare no competing interests.
Additional information
Publisher's note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Teerawongsakul and Ananwattanasuk are joint first authors.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Teerawongsakul, P., Ananwattanasuk, T., Chokesuwattanaskul, R. et al. Programming of implantable cardioverter defibrillators for primary prevention: outcomes at centers with high vs. low concordance with guidelines. J Interv Card Electrophysiol 66, 1359–1366 (2023). https://doi.org/10.1007/s10840-022-01431-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10840-022-01431-6