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Baseline characteristics and outcomes of end-stage renal disease patients after in-hospital sudden cardiac arrest: a national perspective

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Abstract

Purpose

End-stage renal disease (ESRD) is a well-recognized risk factor for the development of sudden cardiac arrest (SCA). There is limited data on baseline characteristics and outcomes after an in-hospital SCA event in ESRD patients.

Methods

For the purpose of this study, data were obtained from the National Inpatient Sample from January 2007 to December 2017. In-hospital SCA was identified using the International Classification of Disease, 9th Revision, Clinical Modification and International Classification of Disease, 10th Revision, Clinical Modification codes of 99.60, 99.63, and 5A12012. ESRD patients were subsequently identified using codes of 585.6 and N18.6. Baseline characteristics and outcomes were compared among ESRD and non-ESRD patients in crude and propensity score (PS)–matched cohorts. Predictors of mortality in ESRD patients after an in-hospital SCA event were analyzed using a multivariate logistic regression model.

Results

A total of 1,412,985 patients sustained in-hospital SCA during our study period. ESRD patients with in-hospital SCA were younger and had a higher burden of key co-morbidities. Mortality was similar in ESRD and non-ESRD patients in PS-matched cohort (70.4% vs. 70.7%, p = 0.45) with an overall downward trend over our study years. Advanced age, Black race, and key co-morbidities independently predicted increased mortality while prior implantable defibrillator was associated with decreased mortality in ESRD patients after an in-hospital SCA event.

Conclusions

In the context of in-hospital SCA, mortality is similar in ESRD and non-ESRD patients in adjusted analysis. Adequate risk factor modification could further mitigate the risk of in-hospital SCA among ESRD patients.

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Data availability

The data that support the finding of this study are available from the corresponding author (MBM) upon reasonable request.

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Authors and Affiliations

  1. Division of Cardiovascular Medicine, West Virginia University Heart and Vascular Institute, Morgantown, WV, USA

    Muhammad Zia Khan, Moinuddin Syed, Pratik Agrawal, Mohammed Osman, Muhammad U. Khan, Anas Alharbi, Mina M. Benjamin, Safi U. Khan & Sudarshan Balla

  2. Section of Electrophysiology, Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California San Diego, 9452 Medical Center Dr., MC 7411, La Jolla, CA, 92037, USA

    Muhammad Bilal Munir

Authors
  1. Muhammad Zia Khan
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  2. Moinuddin Syed
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  3. Pratik Agrawal
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  4. Mohammed Osman
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  5. Muhammad U. Khan
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  10. Muhammad Bilal Munir
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Correspondence to Muhammad Bilal Munir.

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The need for these entities was waived due to the de-identified nature of National Inpatient Sample database and its public availability.

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The authors declare no competing interests.

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Supplementary information

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Supplementary Figure Predictors of mortality in non-end stage renal disease patients after in-hospital sudden cardiac arrest. (JPEG 129 kb)

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Khan, M.Z., Syed, M., Agrawal, P. et al. Baseline characteristics and outcomes of end-stage renal disease patients after in-hospital sudden cardiac arrest: a national perspective. J Interv Card Electrophysiol 63, 503–512 (2022). https://doi.org/10.1007/s10840-021-00977-1

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  • DOI: https://doi.org/10.1007/s10840-021-00977-1

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