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Serum tenascin-C levels in atrium predict atrial structural remodeling processes in patients with atrial fibrillation

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Abstract

Background

Fibro-inflammatory processes in the extracellular matrix are closely associated with progressive structural remodeling in atrial fibrillation (AF). Serum concentrations of tenascin-C (TNC), an extracellular matrix glycoprotein, and of high-sensitivity C-reactive protein (CRP) might serve as a marker of remodeling and progressive inflammation of the aorta and in myocardial diseases. This study aimed to clarify relationships between TNC and CRP in patients with AF.

Methods

This study included 38 patients with AF and five controls without left ventricular dysfunction who underwent catheter ablation. Blood was collected immediately before ablation from the left atrium (LA), right atrium (RA), and femoral artery (FA), and left and right atrial pressure was measured. Levels of TNC in the LA (TNC-LA), RA (TNC-RA), and FA (TNC-FA) and high-sensitivity C-reactive protein (CRP) were measured. Atrial size was also determined by echocardiography.

Results

Levels of TNC corrected by atrial size were maximal in the LA, followed by the RA (3.69 ± 0.32 and 2.87 ± 0.38 ng/mL/cm, respectively). Mean transverse diameter corrected by body surface area was larger and mean atrial pressure was greater in the LA than the RA. A relationship was found between CRP from the femoral vein and TNC-LA and TNC-RA, but not TNC-FA. None of TNC-LA, TNC-RA, or TNC-FA correlated with ANP or BNP in the femoral vein.

Conclusions

Intracardiac (atrial) TNC expression plays an important role in the development of remodeling processes in the atrium with AF. Tenascin-C from the LA and RA (but not TNC, ANP, and BNP from FA) might serve as novel markers of these processes.

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Acknowledgments

The authors thank Ms. Hiromi Nishimura, Ms. Motoko Oku, Ms. Mari Kurata, and Ms. Yoshiko Kurose for providing excellent technical and secretarial assistance.

Funding

This study was partially supported by a Research Grant from the University of Fukui and a JSPS Grant-in-Aid for Scientific Research (C) (Grant number JP16K09426).

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, University of Fukui, 23-3 Shimoaizuki Matsuoka Eiheiji-cho, Fukui, 910-1193, Japan

    Yuichiro Shiomi, Miki Yokokawa, Hiroyasu Uzui, Kaori Hisazaki, Tetsuji Morishita, Kentaro Ishida, Yoshitomo Fukuoka, Kanae Hasegawa, Hiroyuki Ikeda, Naoto Tama, Kenichi Kaseno, Shinsuke Miyazaki, Naoki Amaya & Hiroshi Tada

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  1. Yuichiro Shiomi
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  2. Miki Yokokawa
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Correspondence to Hiroyasu Uzui.

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Shiomi, Y., Yokokawa, M., Uzui, H. et al. Serum tenascin-C levels in atrium predict atrial structural remodeling processes in patients with atrial fibrillation. J Interv Card Electrophysiol 59, 401–406 (2020). https://doi.org/10.1007/s10840-019-00670-4

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  • DOI: https://doi.org/10.1007/s10840-019-00670-4

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