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NT-proBNP, but not ANP and C-reactive protein, is predictive of paroxysmal atrial fibrillation in patients undergoing pulmonary vein isolation

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Abstract

Objective

The purpose of this study is to evaluate the relationship between plasma high-sensitivity C-reactive protein (hs-CRP), atrial natriuretic peptides (ANP), N-terminal-pro-brain natriuretic peptide (NT-proBNP) levels, and the risk and recurrence of atrial fibrillation (AF) after pulmonary vein isolation (PVI) in patients with paroxysmal atrial fibrillation (PAF).

Methods

Plasma ANP, NT-proBNP, and hs-CRP levels were measured before and 3 months after PVI in 33 patients with PAF and 30 control participants.

Results

(1) NT-proBNP levels at baseline were significantly elevated in subjects with PAF compared with control subjects (296.8 ± 272.1 vs. 80.8 ± 69.1 pg/ml), but ANP and hs-CRP levels were normal; NT-proBNP levels normalized 3 months after PVI, but ANP and hs-CRP levels did not change significantly; NT-proBNP levels at baseline in the recurrent group were markedly higher than those in the nonrecurrent AF group (572.7 ± 234.2 vs. 176.8 ± 188.7 pg/ml). (2) Cox stepwise multivariate analysis demonstrated that only elevated NT-proBNP level at baseline was an independent predictor of AF recurrence (p < 0.001) after PVI among 13 variables, such as echocardiographic parameters, plasma ANP, NT-proBNP, and hs-CRP levels. A cutoff value of NT-proBNP ≥ 423.2 pg/ml was a significant risk factor for AF recurrence (p = 0.002).

Conclusions

Elevated NT-proBNP level at baseline, but not ANP and hs-CRP, is a sensitive biomarker for early predicting AF recurrence in patients with PAF.

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Acknowledgments

This study was supported by Chongqing Atrial Fibrillation Research and Therapeutic Center.

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Authors and Affiliations

  1. Department of Cardiology, Chongqing Cardiac Arrhythmia Therapeutic Service Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China

    Jinqi Fan, Hua Cao, Li Su, Zhiyu Ling, Zengzhang Liu, Xianbin Lan, Yanping Xu, Weijie Chen & Yuehui Yin

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  1. Jinqi Fan
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  2. Hua Cao
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  3. Li Su
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  4. Zhiyu Ling
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  5. Zengzhang Liu
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  7. Yanping Xu
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  8. Weijie Chen
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  9. Yuehui Yin
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Correspondence to Yuehui Yin.

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Fan, J., Cao, H., Su, L. et al. NT-proBNP, but not ANP and C-reactive protein, is predictive of paroxysmal atrial fibrillation in patients undergoing pulmonary vein isolation. J Interv Card Electrophysiol 33, 93–100 (2012). https://doi.org/10.1007/s10840-011-9606-9

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  • DOI: https://doi.org/10.1007/s10840-011-9606-9

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