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Analysis of nerve conduction block induced by direct current

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Abstract

The mechanisms of nerve conduction block induced by direct current (DC) were investigated using a lumped circuit model of the myelinated axon based on Frankenhaeuser–Huxley (FH) model. Four types of nerve conduction block were observed including anodal DC block, cathodal DC block, virtual anodal DC block, and virtual cathodal DC block. The concept of activating function was used to explain the blocking locations and relation between these different types of nerve block. Anodal/cathodal DC blocks occurred at the axonal nodes under the block electrode, while virtual anodal/cathodal DC blocks occurred at the nodes several millimeters away from the block electrode. Anodal or virtual anodal DC block was caused by hyperpolarization of the axon membrane resulting in the failure of activating sodium channels by the arriving action potential. Cathodal or virtual cathodal DC block was caused by depolarization of the axon membrane resulting in inactivation of the sodium channel. The threshold of cathodal DC block was lower than anodal DC block in most conditions. The threshold of virtual anodal/cathodal blocks was about three to five times higher than the threshold of anodal/cathodal blocks. The blocking threshold was decreased with an increase of axonal diameter, a decrease of electrode distance to axon, or an increase of temperature. This simulation study, which revealed four possible mechanisms of nerve conduction block in myelinated axons induced by DC current, can guide future animal experiments as well as optimize the design of electrodes to block nerve conduction in neuroprosthetic applications.

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References

  • Bhadra, N., & Kilgore, K. L. (2004). Direct current electrical conduction block of peripheral nerve. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 12, 313–324. doi:10.1109/TNSRE.2004.834205.

    Article  PubMed  Google Scholar 

  • Boyce, W. E., & Diprima, R. C. (1997). Elementary differential equations and boundary value problems, 6th ed pp. 436–457. New York: Wiley.

    Google Scholar 

  • Chiu, S. Y., Ritchie, J. M., Rogart, R. B., & Stagg, D. (1979). A quantitative description of membrane currents in rabbit myelinated nerve. The Journal of Physiology, 292, 149–166.

    PubMed  CAS  Google Scholar 

  • Frankenhaeuser, B., & Huxley, A. F. (1964). The action potential in the myelinated nerve fibre of Xenopus laevis as computed on the basis of voltage clamp data. The Journal of Physiology, 171, 302–315.

    PubMed  CAS  Google Scholar 

  • Hodgkin, A. L., & Huxley, A. F. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of Physiology, 117, 500–544.

    PubMed  CAS  Google Scholar 

  • Hopp, F. A., Zuperku, E. J., Coon, R. L., & Kampine, J. P. (1980). Effect of anodal blockade of myelinated fibers on vagal C-fiber afferents. The American Journal of Physiology, 239, R454–R462.

    PubMed  CAS  Google Scholar 

  • Kuffler, S. W., & Gerard, R. W. (1947). The small-nerve motor system to skeletal muscle. Journal of Neurophysiology, 10, 383–394.

    Google Scholar 

  • Loeb, G. E. (1989). Neural prosthetic interfaces with the nervous system. Trends in Neurosciences, 12(5), 195–201. doi:10.1016/0166-2236(89)90071-4.

    Article  PubMed  CAS  Google Scholar 

  • Manfredi, M. (1970). Differential block of conduction of larger fibers in peripheral nerve by direct current. Archives Italiennes de Biologie, 108, 52–71.

    PubMed  CAS  Google Scholar 

  • McIntyre, C. C., Richardson, A. G., & Grill, W. M. (2002). Modeling the excitability of mammalian nerve fibers: influence of afterpotentials on the recovery cycle. Journal of Neurophysiology, 87, 995–1006.

    PubMed  Google Scholar 

  • Mendell, L. M., & Wall, P. D. (1964). Presynaptic hyperpolarization: a role for fine afferent fibers. The Journal of Physiology, 172, 274–294.

    PubMed  CAS  Google Scholar 

  • Petruska, J. C., Hubscher, C. H., & Johnson, R. D. (1998). Anodally focused polarization of peripheral nerve allows discrimination of myelinated and unmyelinated fiber input to brainstem nuclei. Experimental Brain Research, 121, 379–390. doi:10.1007/s002210050472.

    Article  CAS  Google Scholar 

  • Rattay, F. (1989). Analysis of models for extracellular fiber stimulation. IEEE Transactions on Bio-Medical Engineering, 36, 676–682. doi:10.1109/10.32099.

    Article  PubMed  CAS  Google Scholar 

  • Rattay, F. (2008). Current distance relations for fiber stimulation with pointsources. IEEE Transactions on Bio-Medical Engineering, 55, 1122–1127. doi:10.1109/TBME.2008.915676.

    Article  PubMed  Google Scholar 

  • Rattay, F., & Aberham, M. (1993). Modeling axon membranes for functional electrical stimulation. IEEE Transactions on Bio-Medical Engineering, 40, 1201–1209. doi:10.1109/10.250575.

    Article  PubMed  CAS  Google Scholar 

  • Roth, B. J. (1994). Mechanisms of electrical stimulation of excitable tissue. Critical Reviews in Biomedical Engineering, 22, 253–305.

    PubMed  CAS  Google Scholar 

  • Sassen, M., & Zimmermann, M. (1973). Differential blocking of myelinated nerve fibers by transient depolarization. Pflugers Archiv, 341, 179–195. doi:10.1007/BF00592788.

    Article  PubMed  CAS  Google Scholar 

  • Schwarz, J. R., & Eikhof, G. (1987). Na currents and action potentials in rat myelinated nerve fibres at 20 and 37°C. Pflugers Archiv, 409, 569–577. doi:10.1007/BF00584655.

    Article  PubMed  CAS  Google Scholar 

  • Schwarz, J., Reid, G., & Bostock, H. (1995). Action potentials and membrane currents in the human node of ranvier. Pflugers Archiv European Journal of Physiology, 430(2), 283–292. doi:10.1007/BF00374660.

    Article  PubMed  CAS  Google Scholar 

  • Tai, C., & Jiang, D. (1994). Selective stimulation of smaller fibers in a compound nerve trunk with single cathode by rectangular current pulses. IEEE Transactions on Bio-Medical Engineering, 41, 286–291. doi:10.1109/10.284949.

    Article  PubMed  CAS  Google Scholar 

  • Whitwam, J. G., & Kidd, C. (1975). The use of direct current to cause selective block of large fibers in peripheral nerves. British Journal of Anaesthesia, 47, 1123–1133. doi:10.1093/bja/47.11.1123-b.

    PubMed  CAS  Google Scholar 

  • Zimmermann, M. (1968). Selective activation of C-fibers. Pflugers Archiv fur die Gesamte Physiologie des Menschen und der Tiere, 301, 329–333. doi:10.1007/BF00362643.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgement

This work is supported by the NIH under grants R56-DK-068566, R01-NS-051671, and R01-DK-077783.

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Authors and Affiliations

  1. Department of Urology, University of Pittsburgh, W1354 Biomedical Science Tower, Pittsburgh, PA, 15261, USA

    Changfeng Tai

  2. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA

    James R. Roppolo & William C. de Groat

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  1. Changfeng Tai
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  2. James R. Roppolo
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  3. William C. de Groat
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Correspondence to Changfeng Tai.

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Action Editor: David Terman

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Tai, C., Roppolo, J.R. & de Groat, W.C. Analysis of nerve conduction block induced by direct current. J Comput Neurosci 27, 201–210 (2009). https://doi.org/10.1007/s10827-009-0137-7

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  • DOI: https://doi.org/10.1007/s10827-009-0137-7

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