The aim of the present study is evaluate the effectiveness of an Acceptance and Commitment Therapy (ACT)-based training protocol, in adjunct to token economy and previous parent training, in a sample of children with Attention-Deficit/Hyperactivity Disorder (ADHD). By promoting the reduction of immediate responses to thoughts and feelings, we aimed to reduce the impulsive behaviour of children and to improve their self-regulation.
The protocol was centred on awareness of the present moment, defusion and acceptance of feelings and emotions. Behavioural (Conners’ Parent Rating Scale -Revised: Long version, CPRS-R:L) and severity measures (Clinical Global Impression -Severity, CGI-S) were assessed before and after treatment in a clinical sample of 31 children aged 8–13 years.
At the end of the ACT protocol, children showed significant improvement in global functioning and behavioural symptoms. There were significant improvements in the CPRS subscales Cognitive Problems (p = 0.005), Hyperactivity (p = 0.006), Perfectionism (p = 0.017), ADHD Index (p = 0.023), Global Index: Restless–Impulsive (p = 0.023), Global Index: Total (p = 0.036), DSM IV Inattentive (p = 0.029), DSM IV Hyperactive–Impulsive (p = 0.016), and DSM IV Total (p = 0.003). When controlling for the confounding effect of pharmacological therapy, comorbidities and socio-economic status, treatment maintained a significant effect on the CPRS subscales Perfectionism (partial η2 = 0.31, p < 0.01), Global Index: Restless–Impulsive (partial η2 = 0.29, p < 0.01), Global Index: Total (partial η2 = 0.31, p < 0.01), DSM IV Hyperactive–Impulsive (partial η2 = 0.20, p = 0.02). Symptom severity as rated by CGI-S scores decreased in 74.2% of the children.
This preliminary work on an Acceptance and Commitment Therapy-based child training in children affected by ADHD resulted in significant improvements, measured by a rating scale specific for ADHD.
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Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurobehavioral disorder common in childhood, with symptoms including troubles in paying and maintaining attention, hyperactivity and impulsive behaviour. The worldwide prevalence of ADHD is estimated at 7.2% (Thomas et al. 2015), making it the most prevalent psychiatric disorder of childhood. In Italy, prevalence rates range from 1.3 to 7.0% (Bianchini et al. 2013; Donfrancesco et al. 2014; Gallucci et al. 1993; Mugnaini et al. 2006; Zuddas et al. 2006). ADHD is more frequently diagnosed in boys than in girls, with an estimated ratio of 10:1 in clinic-referred or 3:1 in community samples (Biederman et al. 2002). The life domains that are mostly impaired in individuals with ADHD are the academic, occupational, social, mental-health and self-conceptual ones, negatively impacting the lives of children and of their families (Barkley et al. 2008; Matheson et al. 2013; Stein, 2008). ADHD is described as a self-regulation deficit (Barkley 1997; Puiu et al. 2018; Shiels and Hawk Jr 2010). Core symptoms are associated with problems in maintaining goals and plans, and an insufficient ability to inhibit impulsive responses (Sharma and Couture 2014). Difficulty focusing attention leads to failure to complete tasks, as the inability to maintain and shift attention does not allow children to foresee what is going to happen in the context. Children often fail to recognize the effect of their behaviour, because of a deficit in their ability to regulate alertness, sustain effort and process information at an appropriate rate (Castellanos and Tannock 2002). From a dynamic behavioural developmental perspective (Sagvolden et al. 2005), ADHD might be explained by a short and steep delay-of-reinforcement gradient, which alongside impaired extinction causes impulsiveness and hyperactivity and hampers the establishment of stimulus control. In this way, individuals with ADHD have difficulties in learning to relate behaviour to its consequences.
Mindfulness is a practice that improves the self-regulation of attention and emotions (Teasdale et al. 1995). It has been described as “a particular way of paying attention on purpose, in the present moment, and non-judgmentally” (Kabat-Zinn 1994) that helps clients to notice thoughts, sensations, emotions and urges, accepting them without reacting. Mindfulness practice can help training individuals to pay attention to the relevant aspects of their inner and external environment, helping them to notice and learn the relations between events and behaviour (Shapiro et al. 2006). As self-regulation impairment is a key feature of ADHD (Barkley 1997), studies on mindfulness practice have demonstrated its many potential positive effects, including the reduction of behavioural symptoms of inattention and impulsivity, as well as of stress, anxiety and depression (Zylowska et al. 2008). Two recent reviews (Burke 2010; Swain et al. 2015) have found that mindfulness-based interventions are effective for the treatment of children and adolescents with different mental disorders, such as oppositional-defiant and conduct disorder, anxiety, depression, obsessive-compulsive disorder, chronic pain and substance abuse. To our knowledge, there are only a few studies that explore the effects of mindfulness training in children or adolescents with ADHD (Semple et al. 2005, 2010; Van de Weijer-Bergsma et al. 2012; Van der Oord et al. 2012; Zylowska et al. 2008), indicating that mindfulness meditation training is feasible and has positive effects. Mindfulness is a core component of many CBT interventions. Cognitive-behavioural-based programs (i.e. school-based behavioural reinforcement, behavioural parent training and social skills training programmes) are currently among the top evidence-based interventions for treating children with ADHD (The Multimodal Treatment Study of Children with ADHD [MTA] Cooperative Group 1999). However, these programs, which have traditionally focused on putting children’s behaviour under the control of an external rule, given by a trainer in a specific context, show several limitations (Van der Oord et al. 2012). We hypothesise that rule-following may reduce the possibility that children directly learn and be regulated by contact with environmental contingencies. This could also explain the well-known lack of generalization to other contexts and behavioural topographies, which different authors have described regarding traditional Cognitive Behavioural treatments for ADHD (Chambles and Ollendick 2001; Pelham and Fabiano 2008).
Murrell et al. (2015) studied the efficacy of an Acceptance and Commitment Therapy (ACT)-based protocol, a so-called ‘third wave’ cognitive-behavioural intervention (Hayes et al. 2004, 1999; Wilson and Luciano 2002) for the treatment of ADHD. This preliminary investigation assesses the feasibility of using ACT in school-aged children with comorbid ADHD, learning disorders and behaviour problems, in order to increase committed actions connected to personal values. Results suggested that benefits are evident for some children after a short intervention period.
ACT assumes a contextualistic philosophy of science, a theory of language and cognition named Relational Frame Theory (RFT) (Hayes et al. 2001) and an applied theory of psychopathology and psychological change (Hayes et al. 2006). This cognitive-behavioural therapy aims to help clients stuck in their daily lives to pursue a “valued” life, by clarifying personal values and identifying their own goals and actions linked to their values. An ACT protocol aims to build psychological flexibility by encouraging people to be aware of inner experiences and external signals and to stay in contact with the uncomfortable ones, as long as this is what patients consider valued living (Hayes et al. 2006; Simons and Gaher 2005). Several studies show that ACT-based interventions are effective in a number of different clinical and non-clinical contexts, including psychiatric and psychological conditions (such as depression, anxiety, obsessive-compulsive disorders, borderline personality disorder and drug dependence), prevention and health promotion (such as the management of chronic pain, smoking cessation and obesity) and organizational environments (for example, stress management, staff training for teachers, working reintegration, stigma and prejudice) (Öst, 2014; A-Tjak et al. 2015; Ruiz 2010; Powers et al. 2009; Hayes et al. 2006). In recent years, ACT-based interventions have been studied also for patients in the developmental age and some intervention protocols have been applied with children and adolescents (Ciarrochi et al. 2012; Greco and Hayes 2008). Current studies, although pivotal, demonstrated promising effects on chronic pain and psychological disorders (Swain et al. 2015). Mindfulness is an important element in ACT protocols. In this conceptual framework, mindfulness is integrated as a practice that contributes to build the overarching behavioural pattern for psychological flexibility, which includes not only being open to internal and external events and being focused on the present moment, but also being committed to act in the direction of one’s own values to adaptively build a meaningful life.
In this explorative single-arm open-label study, we aimed to assess whether an ACT-based training, conducted in a group of Italian children and adolescents with ADHD, could lead to changes in global functioning and behavioural symptoms, measurable through clinical rating scales specific for ADHD, while considering fundamental confounders.
All parents had completed an ACT-based Cognitive Behavioural Parent Training (according to the protocol described in Vanzin et al. 2018b) a maximum of 3 months before the evaluation of children for the inclusion in this study. Potential participants for this study were selected, following enrolment criteria, among all children with a diagnosis of ADHD enlisted for a group psychological treatment. A complete study flow-chart is provided in Fig. 1. A clinical sample of 36 children and adolescents who were referred to the Child Psychopathology Unit of our Institute for ADHD treatment was recruited over 3 years (from 2015 to 2018). Inclusion criteria were age between 8 and 13 years and a diagnosis of ADHD. All participants were diagnosed by a child neuropsychiatrist in accordance with the DSM 5 criteria (American Psychiatric Association [APA] 2013). A child psychologist experienced in the diagnosis of ADHD (LV) confirmed independently the diagnoses by through direct observation and the administration of the semi-structured interview Development and Well-Being Assessment (DAWBA) (Goodman et al. 2000). The Wechsler Intelligence Scale for Children–III (Wechsler 1991) or –IV (Wechsler 2003) was used to obtain the Full Scale Intelligence Quotient (FSIQ). Only patients with FSIQ higher than 85 were included. Any major neurological or medical condition, a psychiatric diagnosis of autism spectrum disorder or specific language impairment (but no other psychiatric co-morbidities), or the fact that parents did not complete their ACT-based parent training, were considered exclusion criteria. Thirty-six children with ADHD were enrolled in the rehabilitation treatment program. Five dropped out of the study (14%) and their baseline data were not analysed. Thirty-one patients remained in the study until its end and they had a complete set of data (Fig. 1).
Mean age was 10.7 years (SD = 1.4) and the percentage of males was 93.5% (n = 29). The mean socio-economic status (SES) of families was 59.5 (DS = 19.5). Different types of ADHD were included in the sample: 80.6% of children were diagnosed Combined-ADHD, 9.7% predominantly Inattentive—ADHD, 6.5% not otherwise specified and 3.2% predominantly Hyperactive-Impulsive ADHD. 16 patients (51.6%) who received the treatment had a co-diagnosis with other psychopathologies, and among them 38.7% (n = 12) of participants had a co-diagnosis with a learning disability or speech disorder. Patients’ demographics and clinical characteristics are provided in Table 1.
All subjects took part in a treatment program that lasted 9 months overall and consisted of 26 weekly group sessions of 90 min. Each group was composed of four to five children. Before the intervention, therapists met with children and their parents to introduce the program, discuss potential benefits or shortcomings, investigate their motivation to participate, introduce the reinforcement and punishment system and point out the importance of carrying out homework assignments and pursuing weekly objectives. The program aimed to gradually build the ability to contact and describe the own needs, wants and desires of patients and to reduce their problematic behaviour, while steering children and adolescents towards a more adaptive behavioural pattern. Experiential exercises helped to build sensitivity to actual contingencies in social situations, and mindfulness practice was used to help children notice thoughts, sensations, emotions and urges, and to accept them without reacting. Mindfulness training increased the ability of children to distance themselves from internal experiences and “kindly return” to awareness of the present. Moreover, treatment helped children to create a place to identify and choose what really matters for them in their lives. During the training, children developed not only mindfulness abilities, but also other psychological skills. They had the possibility to move through all the six core ACT processes: acceptance, cognitive defusion, being present, self as context, values and committed action. In sessions 1–4, we created motivation to collaborate in a group context and introduced personal values and the mindfulness practice; we identified personal values in life domains and consistent “committed actions” as well as barriers (feelings, thoughts and external stimuli) to reaching personal goals. In session 5–14, we promoted defusion skills and the meaning of self as context, then we developed mindfulness abilities through specific exercises; we also taught children to read emotions as discriminative stimuli of an action compatible with the current context. In the fourth phase (sessions 16–19), we focused on perspective taking in order to foster empathy and social sensitivity. In sessions 20–22, we reviewed and consolidated the contents learned in previous sessions, trying to help children to cope with problematic situations in their daily lives (inner or external) and enabling them to generalize learned skills. In the last phase (sessions 23 to 25), we re-elaborated in a creative way what the children had learnt (for example, making a movie to be seen with parents). The main aspect of treatment was the creation of a group metaphor that the trainers developed to suit children’s language and experiences. The group metaphor creates an idea of shared interests, giving a sense of continuity to the training activity and supporting the collective ACT processes. For a short overview of the session themes and exercises, see Table 2.
We reinforced target behaviours during sessions and increased motivation to complete homework by using token economy. Our reinforcement schedule assigned a reinforcer if children displayed the target behaviour required for each activity. The target behaviour involved being present, engaged and aware of what was happening. After a conditioned signal sound, children could double their token gain if the whole group respected silence, took some deep breaths and listened to trainers. Treatment adherence and fidelity were rewarded using the token economy procedure, as described in the book by Vanzin (2018a). Through the token economy, we could increase children’s interest and attendance to sessions and ensure the completion of homework. Patients earned points by complying to all these aspects, strongly increasing treatment adherence and fidelity. Sessions were conducted by two experienced psychotherapists among A.V., V.M., M.F. During the intervention, therapists met on a weekly basis to discuss group progress and monitor the state of treatment. Sessions were supervised weekly by an expert cognitive-behavioural psychotherapist (L.V.). In the context of this group training, children had one individual session after 4 months from treatment start. The individual sessions were supplemental face-to-face interviews between therapist and child, aimed to highlight the strengths and weaknesses of the child training, and to point out potential issues; in the context of these sessions, generalization of abilities acquired during the group training is promoted by analysing areas of daily life in which they could be applied.
Data on clinical conditions were collected, including pharmacological treatment, diagnosis and co-diagnoses and demographic characteristics including age, gender and socioeconomic status (SES). The Hollingshead 9-point scale for parental occupation (Hollingshead 1975) was used to rate SES on a scale from 10 to 90: subjects with scores between 10 and 30 had a low SES, subjects with scores between 40 and 60 had a medium SES, subject with scores between 70 and 90 had a high SES.
Child training effectiveness was measured through two outcome measures: Conners’ Parent Rating Scales-Revised: Long version (CPRS-R:L) (Conners 2001) completed by the children’s mothers and Clinical Global Impression–Severity scale (CGI-S) (Guy 1976) completed by non-blind independent clinicians. In the present study, CPRS-R:L and CGI-S were administered before the beginning of treatment and after 9 months, i.e. at the end of treatment.
The CPRS-R:L is a reliable instrument for assessing ADHD and monitoring treatment (Pliszka et al. 2007). CPRS-R:L is a questionnaire used to assesses behavioural problems and ADHD symptoms, to be completed by parents. The CPRS-R:L, suitable for children aged 3 to 17, provides an assessment of behavioural and psychopathological problems and it particularly targets ADHD symptoms. The Italian version adapted by Nobile et al. (2007) is an 80-item scale that produces T-scores for 14 subscales: cognitive problems/inattention, oppositional behaviour, hyperactivity, anxiety and shyness, perfectionism, social problems, psychosomatic behaviour, CPRS-R:L Global Index (comprising Restless–Impulsive and Emotional Lability), ADHD Index and DSM-IV symptoms subscales (comprising DSM-IV Inattentive and DSM-IV Hyperactive-Impulsive). The CPRS-R:L has well-established reliability and validity (Conners 2001) in rating the behaviour of children with ADHD and in assessing an intervention’s effectiveness. In the present sample, before treatment, the oppositional behaviour, cognitive problems/inattention, hyperactivity, social problems, psychosomatic behaviour, CPRS-R:L Global Index, ADHD Index and DSM-IV symptoms subscales showed an acceptable to good internal reliability (Cronbach’s α ranging from 0.766 to 0.853); anxiety and shyness and perfectionism subscales showed a questionable reliability (Cronbach’s α 0.680 and 0.657, respectively). After treatment, the oppositional behaviour, cognitive problems/inattention, hyperactivity, psychosomatic behaviour, CPRS-R:L Global Index, ADHD Index and DSM-IV symptoms subscales showed an acceptable to excellent internal reliability (Cronbach’s α ranging from 0.711 to 0.915); social problems, anxiety and shyness and perfectionism subscales showed a questionable reliability (Cronbach’s α 0.668, 0.655 and 0.273, respectively).
The CGI-S provides an overall clinician-determined summary of psychopathologic severity on a 7-point scale (1 = normal; 7 = extremely ill) (Busner and Targum 2007) and is one of the most widely used assessment tools in psychiatry.
Both assessment tools have demonstrated acceptable reliability and validity in previous studies with Italian children (Masi et al. 2013; Masi et al. 2014). Since this was a preliminary study, we applied no blinding. However, the CGI-S rater was a psychiatrist independent from the treating clinical psychologists.
Descriptive statistics were performed for age, gender, SES, type of ADHD and co-diagnosis. Normality tests were used to determine if variables and scores of each CPRS-R:L subscale had a normal distribution. Mean and standard deviation (SD) were used for normally distributed continuous variables, median and interquartile range for non-normally distributed variables, while frequency and percentage were used for categorical variables. In order to determine if CPRS-R:L subscale scores were significantly different before vs. after treatment, we performed paired samples T-tests or Wilcoxon signed rank tests, as required. The significance level was set at p < 0.05 and effect size was expressed as Cohen’s d or Wilcoxon’s r, as required. We aimed to control these analyses for possible confounding variables such as medication (The MTA Cooperative Group, 1999), social economic status (Nobile et al. 2010, Biederman et al. 2002) and comorbidity (Frigerio et al. 2006, Bianchi et al. 2017), which were found to be associated with severity of symptoms and different response to treatment. Gender and age were not included in our list of covariates, because we analysed CPRS T-scores, which are already weighed for age and gender. We used repeated measures ANCOVA models to assess before vs. after treatment changes controlled for covariates: treatment was used as the within-group factor; pharmacotherapy × comorbidity × SES as between-group factor. We applied the model to each CPRS-R:L subscale that was significantly changed in non-controlled analyses. We reported the results of ANCOVAs for each CPRS-R:L subscale, including the significance and R2 of the whole model, and the significance and effect size (ES) as partial eta squared for treatment, to check if it was still significant after controlling for covariates. Changes on the CGI-S scale were assessed by the Wilcoxon Signed Rank Test. All analyses were conducted using IBM SPSS Statistics, version 22.0 SPSS.
Significant differences between scores measured before vs. after treatment were found in the subscales Oppositional (p = 0.048, d = 0.31) Cognitive Problems (p = 0.005, d = 0.5), Hyperactivity (p = 0.006, d = 0.56), Perfectionism (p = 0.017, r = 0.3), ADHD Index (p = 0.023, d = 0.4), Global Index: Restless – Impulsive (p = 0.023, d = 0.44), Global Index: Total (p = 0.036, d = 0.39), DSM IV Inattentive (p = 0.029, d = 0.45), DSM IV Hyperactive – Impulsive (p = 0.016, r = 0.31), DSM IV Total (p = 0.003, d = 0.57). The complete list of results is available in Table 3.
We re-analysed changes on the CPRS scores by ANCOVA, taking into account the potential influence of covariates including concomitant drug treatment, presence of comorbidities and SES. As shown in Table 4, the effect of treatment remained significant for the CPRS subscales Perfectionism (partial η2 = 0.31, p < 0.01), Global Index: Restless–Impulsive (partial η2 = 0.29, p < 0.01), Global Index: Total (partial η2 = 0.31, p < 0.01), DSM IV Hyperactive–Impulsive (partial η2 = 0.20, p = 0.02).
CGI-S scores demonstrated global improvement: before treatment the CGI-S median was 4 (interquartile range 1), and 3 after treatment. This change was significant (p < 0.001 at Wilcoxon Signed Rank Test). After treatment, 74.2% of the patients (n = 23) improved in the severity index. Of this, 19 (61.3%) patients shifted one step, and 4 (13%) more than one step. No patient presented with a worse CGI-S score after treatment. Details are presented in Table 5.
The aim of the present study was to explore the efficacy of an ACT-based treatment, in adjunct to token economy and previous parent training, in reducing impulsiveness and improving self-regulation in children with ADHD. This study of a ‘third wave’ behavioural treatment in a group-based setting is pivotal, as it examined measurable changes in ADHD rating scales (CPRS-R:L and CGI-S) and not only in ACT processes; the positive results we observed support a real therapeutic efficacy of this ACT-based child training. During the training, children had the possibility to move through the six ACT processes: they were exposed to the contact with the present moment, to the process of acceptance, to the cognitive defusion, to the self as context, to values and to committed actions. Children gradually built the ability to contact and describe their own needs, wants and desires. Through the experiential exercises, the analysis of social situations and enhancement of perspective taking abilities, we led children into using a contingency-governed approach for choosing their behaviours.
The clinical question addressed in this study concerned the effectiveness of ACT-based child training for ADHD rehabilitation. Although we observed a quite small sample of children, we controlled the results for the potential effect of confounding variables such as pharmacotherapy, the presence/absence of comorbidity and SES. We found several cases in which pharmacotherapy, comorbidity and SES may have significantly influenced the outcome of therapy. A quantitative examination of the role of these covariates may deserve further investigation in larger and more representative studies. In particular, after controlling for these confounders, the effect of treatment remained significant, and retained a medium effect size, regarding the four following CPRS subscales. Changes in the subscale Perfectionism, although significant, were minimal and scores were always below the clinical attention threshold. Improvements in the subscales Global Index: Restless–Impulsive, Global Index: Total and DSM IV Hyperactive–Impulsive suggest that treatment may have had an effect on impulsiveness and, indirectly, on emotional aspects. The reduction of impulsive acts, observed by parents, might be interpreted as a consequence of the mindfulness components of the present treatment. Children may have learned to observe emotions and thoughts, without reacting impulsively. Indeed, mindfulness consists also of observing thoughts and emotions and distancing from them, which reduces impulsive and automatic reactions (Peters et al. 2015). By freeing themselves from the cycle of thinking–feeling–acting, children may acquire the space necessary to concentrate on what they are doing in the present moment, to reflect, and to learn. Another hypothesis is that children may have improved their level of awareness of mind-wandering, which is the first step required to allow attention to be re-focused on a specific task. Results also demonstrated a reduction in general psychopathology (CPRS Global Index Total). The CPRS Global Index Total is informative regarding changes in both externalised symptoms and emotional or internalised symptoms and thus it is helpful for monitoring treatment progress (Conners 2001). Therefore, the results suggest the possibility of conducting an ACT-based child training in this population. It is possible to speculate that the effect size of treatment may be higher than the one we observed in this preliminary study, due to the small sample size, and most of all due to the fact that this ACT-based CT still has to be optimized.
Since this is an exploratory study, we also considered non-controlled results. The largest improvements over time were in the CPRS-R:L subscales Cognitive Problems, Hyperactivity, DSM IV Inattentive and DSM IV Total, as shown by effect size. The Cognitive Problems and DSM IV Inattentive subscales refer to the possibility that children may struggle to concentrate, may be easily distracted by external stimuli, may not pay attention to details, may make frequent mistakes from distraction, may be ‘forgetful’ and may have organisational problems and difficulties in completing tasks. The fact that two CPRS-R:L subscales consistently indicated a reduction of inattention allows us to speculate that practicing mindfulness may have fostered in children a higher awareness of moments of distraction and a better ability to return with their minds to the ‘here and now’. In fact, an important part of this child training course consisted of leading children into developing awareness of their own thoughts, thus becoming able to detect distractions. Children with ADHD are continuously shifting their attention focus and are not aware of being distracted. We believe that they should be encouraged to improve their awareness of distractions before enhancing their ability to maintain attention. The Hyperactivity subscale refers to difficulties in sitting or dedicating themselves to the same task for a long time, as well as restlessness. Our hypothesis is that work on the acceptance of one’s emotions and impulses, whatever they may be, may have helped the children to accept the presence of a minor discomfort (the desire to move or to leave the activity to start another one) when this was necessary to achieve something important for them. This ACT process is described by the term ‘self-regulation’. During the training, children were encouraged to explore and reflect on what is important in daily life activities, sharing with the rest of the group personal qualities that they considered important to show. We had the opportunity to guide children into choosing functional behaviours to develop their qualities, while experiencing the possibility of not acting immediately on every impulse or every thought that crossed their mind.
Through CGI-S scores, we assessed the severity of patients’ illness and found a significant improvement after treatment. In our sample, 74.2% of the children shifted from a more severe functional impairment class to a less severe one. Therefore, there is agreement between clinicians and parents regarding the patients’ general improvement.
Limitations and Future Research Directions
Results of the present work must be considered preliminary, as a control group would be necessary to assess treatment efficacy properly. For the same reason, we did not perform corrections for multiple comparisons. Another limitation was in the sample size of 31 patients, which was still a larger cohort as compared to previous studies. Although it would be best to include fewer covariates in the ANCOVA with a sample size of 31, we included pharmacotherapy, comorbidities and SES, as they are all fundamental from a clinical point of view. Our study did not comprise an evaluation of patients who dropped out of treatment: the most/least severe participants may have dropped out of treatment, thus biasing results. In addition, our current working protocol does not involve a follow-up reassessment of outcomes, which is a crucial aspect to verify the generalization of treatment achievements. Regarding the generalizability of the present study, our sample is in line with the Italian population (Bonati et al. 2015), although we acknowledge that the epidemiology of ADHD in Italy is not overlapping with that of other countries, and this constitutes a limitation of our study. The ACT-based cognitive behavioural parent training was completed before the ACT-based cognitive behavioural child training started. Therefore, our baseline evaluation took into account the immediate effects of parent training. However, the parent training may have had ongoing effects that cannot be accounted for and that may have contributed to the treatment effects in the present study. Another aspect we could not control for, was the possibility of a direct effect of the token economy system. Unfortunately, the lack of a control group did not allow us to investigate these aspects, which constitutes a limitation of the present study. We evaluated the intervention as a package, although some specific components of the program were evidence-based for ADHD (e.g.: token systems) and others were not (e.g.: mindfulness practice). Further research is needed to single out the effective and ineffective components of the program and improve its efficiency. In order to assess the importance of the token economy within the ACT context, future studies should include a waiting list group, a CBT CT group and an ACT CT group, with both training groups including the token economy. Our study relied on parents’ reports of symptoms and ratings of non-blind clinicians; thus, findings may have been influenced by expectancy effects. We recommend for the future to include direct measures of attention and impulsive behaviour, perhaps through neuropsychological tasks. Moreover, investigating the generalization of changes, for instance to the school setting, was not within the aims of this work and it should be investigated in future studies.
Our results indicate an improvement in line with the only previous study on the feasibility of ACT with ADHD children, which investigated changes in ACT processes (Murrel et al. 2015). This preliminary study demonstrates the effectiveness of ACT-based child training in a sample of children with ADHD using clinical rating scales specific for ADHD and considering fundamental confounders such as pharmacotherapy, comorbidity and SES. The promising results of this study should encourage the conduction of future clinical trials on the effectiveness of ACT-based child training for children with ADHD, possibly including a larger number of patients with more homogeneous characteristics. Such studies should also apply clinical rating scales including the CPRS-R:L and CGI, in order to provide a critical mass of evidence that might be used in the future to guide innovative clinical interventions based on the ACT approach.
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The financial support from the Italian Ministry of Health (Ricerca Corrente 2019, to MP, MN, MM) is gratefully acknowledged. The funding public institutions had no role in any part of the work.
LV conceived the study and wrote the manuscript; AV and VM collected data and wrote the manuscript; MP analysed data and critically supervised manuscript writing; AO, AR analysed data; GP, MM conceived the study; MN conceived the study and critically supervised manuscript writing.
Conflict of Interest
The authors declare that they have no conflict of interest.
This study received approval by the Ethics Committee of the Scientific Institute I.R.C.C.S. E. Medea, scientific section of the Association “La Nostra Famiglia”, Bosisio Parini (LC), Italy. The study was performed in accordance with the ethical standards set forth in the 1964 Declaration of Helsinki and its later amendments.
Written informed consent and assent was proposed to all parents and participants, respectively. Only in case they both agreed to participate, patients were enrolled in this study.
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Vanzin, L., Mauri, V., Valli, A. et al. Clinical Effects of an ACT-Group Training in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder. J Child Fam Stud 29, 1070–1080 (2020). https://doi.org/10.1007/s10826-019-01546-x