References
Swann K. Sperm factors and egg activation: PLCzeta as the sperm factor that activates eggs: 20 years on. Reproduction. 2022;164:E1–4.
Avidor-Reiss T, Uzbekov R. Revisiting the mystery of centrioles at the beginning of mammalian embryogenesis. J Assist Reprod Genet. 2023. https://doi.org/10.1007/s10815-023-02927-4.
Liu J, Hermo L, Ding D, Wei C, Mann JM, Yan X, Melnick AF, Wu Y, Withrow A, Cibelli J, Hess RA, Chen C. SYPL1 defines a vesicular pathway essential for sperm cytoplasmic droplet formation and male fertility. Nat Commun. 2023;14:5113.
Leung MR, Zeng J, Wang X, Roelofs MC, Huang W, Zenezini Chiozzi R, Hevler JF, Heck AJR, Dutcher SK, Brown A, Zhang R, Zeev-Ben-Mordehai T. Structural specializations of the sperm tail. Cell. 2023;186(2880-2896):e2817.
Zhou L, Liu H, Liu S, Yang X, Dong Y, Pan Y, Xiao Z, Zheng B, Sun Y, Huang P, Zhang X, Hu J, Sun R, Feng S, Zhu Y, Liu M, Gui M, Wu J. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Cell. 2023;186(2897-2910):e2819.
Cooper TG. The epididymis, cytoplasmic droplets and male fertility. Asian J Androl. 2011;13:130–8.
Cooper TG, Yeung CH, Fetic S, Sobhani A, Nieschlag E. Cytoplasmic droplets are normal structures of human sperm but are not well preserved by routine procedures for assessing sperm morphology. Hum Reprod. 2004;19:2283–8.
Čipak A, Stanić P, Đurić K, Serdar T, Suchanek E. Sperm morphology assessment according to WHO and strict criteria: method comparison and intra-laboratory variability. Biochemia Medica. 2009;19:87–94.
Bloom G, Nicander L. On the ultrastructure and development of the protoplasmic droplet of spermatozoa. Z Zellforsch Mikrosk Anat. 1961;55:833–44.
Liu L, He Q, Li Y, Zhang B, Sun X, Shan J, Pan B, Zhang T, Zhao Z, Song X, Guo Y. Serum SYPL1 is a promising diagnostic biomarker for colorectal cancer. Clin Chim Acta. 2020;509:36–42.
Yeung CH, Wagenfeld A, Nieschlag E, Cooper TG. The cause of infertility of male c-ros tyrosine kinase receptor knockout mice. Biol Reprod. 2000;63:612–8.
Pandruvada S, Royfman R, Shah TA, Sindhwani P, Dupree JM, Schon S, Avidor-Reiss T. Lack of trusted diagnostic tools for undetermined male infertility. J Assist Reprod Genet. 2021;38:265–76.
Gipson JD, Bornstein MJ, Hindin MJ. Infertility: a continually neglected component of sexual and reproductive health and rights. Bull World Health Organ. 2020;98:505–6.
Barratt CLR, De Jonge CJ, Sharpe RM. ‘Man Up’: the importance and strategy for placing male reproductive health centre stage in the political and research agenda. Human reproduction (Oxford, England). 2018;33:541–5.
Mehta A, Nangia AK, Dupree JM, Smith JF. Limitations and barriers in access to care for male factor infertility. Fertil Steril. 2016;105:1128–37.
Acknowledgements
We thank Drew L. Caswell for the Fig. 1 drawing and Dr David Albertini, Dr Tzviya Zeev Ben, Dr Mingxi Liu, and Dr Chen Chen for reviewing, editing, and commenting on the manuscript.
Funding
TAR is supported by Agriculture and Food Research Initiative Competitive Grant number OHOW-2020-02790 from the USDA National Institute of Food and Agriculture and Grant number 1R15HD110863-01 from NIH-NICHD.
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Avidor-Reiss, T. Renaissance in sperm cytoplasmic contribution to infertility. J Assist Reprod Genet 41, 293–296 (2024). https://doi.org/10.1007/s10815-023-02987-6
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DOI: https://doi.org/10.1007/s10815-023-02987-6