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Perinatal outcomes in 6640 singleton pregnancies after donor oocyte IVF across three continents over 7 years

  • Assisted Reproduction Technologies
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Abstract

Purpose

Are trends in singleton donor oocyte IVF perinatal outcomes consistent over time among four international ethnically diverse infertility centers?

Methods

This retrospective cohort consisted of an infertility network of four international IVF centers across three continents. Singleton live births resulting from fresh and frozen donor oocyte embryo transfers from January 1, 2012 to December 31, 2018 were included. The main outcome measures were birth weight (BW), preterm birth (PTB), large for gestational age (LGA), small for gestational age (SGA) and gestational age (GA) at delivery.

Results

The entire cohort (n = 6640) consisted of 4753 fresh and 1887 frozen donor oocyte embryo transfers. Maternal age, parity, body mass index, neonatal sex and GA at delivery were similar for fresh and frozen donor oocyte embryo transfers in the entire cohort and within each infertility center. All four centers had a trend of decreased BW and rates of PTB before 32 weeks annually, although significance was not reached. Three of the four centers had annual increased trends of PTB before 37 weeks and LGA newborns, although significance was not reached. BWs for the entire cohort for fresh and frozen donor embryo transfers were 3166 g ± 601 g and 3137 g ± 626 g, respectively.

Conclusion

Similar trends in perinatal outcomes were present across four international infertility centers over 7 years. The overall perinatal trends in donor oocyte IVF may be applicable to centers worldwide, but further studies in more geographic regions are needed.

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Acknowledgements

Authors would like to acknowledge Teresa Lopez-Rovira, Rita Vassena, Desiree Garcia, Montserrat Sabaté Lapuyade, Vanessa Pérez Martínez, Begoña Anguita Bustamante, José Roberto Alegretti, Eduardo Motta and Daniel Duvall for local study support.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Jaimin S. Shah

  2. Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA

    Jaimin S. Shah

  3. Boston IVF—Eugin Group, 130 Second Ave., Waltham, MA, 02451, USA

    Jaimin S. Shah & Denny Sakkas

  4. Present Address: Shady Grove Fertility, 2255 E Mossy Oaks Rd, Suite 620, Spring, Houston, TX, 77389, USA

    Jaimin S. Shah

  5. Department of Maternal-Fetal Medicine, BCNatal, Barcelona Center for Maternal-Fetal and Neonatal Medicine, Universitat de Barcelona, Hospital Clínic, 08950, Barcelona, Spain

    Francesc Figueras

  6. Eugin, 08029, Barcelona, Spain

    Anna Blàzquez & Sarai Brazal

  7. Biogenesi Reproductive Medicine Centre—Gruppo Eugin, Istituti Clinici Zucchi, Monza, Italy

    Jose Buratini, Mariabeatrice Dal Canto, Roberta Iemmello & Mario Mignini Renzini

  8. FecunMed—Eugin Group, Granollers, Spain

    Rafael Buscà & Maider Ripero

  9. Huntington Medicina Reproductiva—Eugin Group, São Paulo, SP, Brazil

    Catherine K. Jacobs & Aline R. Lorenzon

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  1. Jaimin S. Shah
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  2. Francesc Figueras
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Contributions

All authors contributed to the conceptualization of the idea and study design, data collection, critical revision of the manuscript, data interpretation and approved the final draft of the manuscript. F.F. performed the analysis, and J.S.S drafted the manuscript.

Corresponding authors

Correspondence to Jaimin S. Shah or Denny Sakkas.

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Ethics approval

This research study was conducted retrospectively from data obtained for clinical purposes. We consulted with the IRB at each institution, and our study did not require ethical approval. IRB waivers of ethical approval were granted from the Committee on Clinical Investigations at Beth Israel Deaconess Medical Center (Boston), CEIM of EUGIN (Barcelona, FecunMed-Granollers) and Ethics in Research Committee/National Committee of Ethics in Research (Brazil).

Conflict of interest

FF received fees for statistical analysis of the current work. DS is on the speaker panel of EMD Serono and is Deputy Editor of Human Reproduction.

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Shah, J.S., Figueras, F., Blàzquez, A. et al. Perinatal outcomes in 6640 singleton pregnancies after donor oocyte IVF across three continents over 7 years. J Assist Reprod Genet 40, 2903–2911 (2023). https://doi.org/10.1007/s10815-023-02965-y

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