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Single best euploid versus single best unknown-ploidy blastocyst frozen embryo transfers: a randomized controlled trial

  • Assisted Reproduction Technologies
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

This paper aims to investigate the efficacy of IVF with preimplantation genetic testing for aneuploidy (PGT-A), using only best-scoring blastocysts from young (≤ 35 years) infertile patients undergoing single blastocyst frozen embryo transfers (FET).

Method

In this randomized controlled trial (RCT) registered 29 March 2017, 302 infertile patient-couples eligible to participate underwent autologous ICSI blastocyst freeze-all cycles. Two-hundred and twenty patient-couples satisfied the inclusion criteria (i.e., female age ≤ 35 years, two-day 5 ≥ 2BB blastocysts) and were randomized to either the PGT-A (PGT-A group, n = 109) selection arm or morphology score (morphology group, n = 111) selection arm. In both arms, the highest ranking (by morphological score) blastocysts were selected for FET.

Results

Of the 109 best-scoring blastocysts that underwent PGT-A, 80 were predicted to be euploid (73.4%) and were transferred in FET (euploid subgroup). There was no statistical difference in LB rate between the euploid subgroup and morphology group (56.3% vs 58.6%, odds ratio 0.91 (95% CI 0.51–1.63), p = 0.750). In a multiple logistic regression, the transfer of euploid blastocysts was not found to be a significant predictor of LB when adjusting for female age, infertility duration, antral follicle count, and blastocyst quality, with the independent odds expressed as 0.91 (95% CI 0.50–1.66, p = 0.760).

Conclusion

In young (≤ 35 years) infertile patients with at least two ≥ 2BB blastocysts, PGT-A blastocyst selection does not result in an enhanced LB rate, with the evidence suggesting that the effectivity of PGT-A may be limited by the effectivity of TE biopsy.

Trial registration: ClinicalTrials.gov ID: NCT03095053.

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Authors and Affiliations

  1. Antalya IVF, Halide Edip Cd. No:7, Kanal Mh, 07080, Antalya, Turkey

    Kemal Ozgur, Murat Berkkanoglu, Hasan Bulut & Kevin Coetzee

  2. BiyoGenom, Genetic Laboratory, 07040, Antalya, Turkey

    Gonul Didem Akay Yoruk & Nevrah Nal Candurmaz

Authors
  1. Kemal Ozgur
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  2. Murat Berkkanoglu
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  3. Hasan Bulut
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  4. Gonul Didem Akay Yoruk
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  5. Nevrah Nal Candurmaz
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  6. Kevin Coetzee
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Correspondence to Kevin Coetzee.

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Ozgur, K., Berkkanoglu, M., Bulut, H. et al. Single best euploid versus single best unknown-ploidy blastocyst frozen embryo transfers: a randomized controlled trial. J Assist Reprod Genet 36, 629–636 (2019). https://doi.org/10.1007/s10815-018-01399-1

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  • DOI: https://doi.org/10.1007/s10815-018-01399-1

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