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Subclinical Pregnancy Losses Among Women Undergoing In-Vitro Fertilization With ICSI

  • Assisted Reproduction
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Background: The purpose of this study is to asses the frequency of subclinical pregnancy loss (SPL) among women undergoing controlled ovarian hyperstimulation (COH) and in-vitro fertilization with ICSI.

Methods: The study was retrospectively conducted in a private IVF center. SPL was defined by a temporary rise in serum βhCG, along with the absence of signs of intra- and extra-uterine pregnancy by transvaginal ultrasonography. Overall 5273 COH and ICSI cycles with embryo transfer (ET) were segregated according to serum E2 levels percentiles (-24th, 25th, 74th, and 75th), women age and the type of spermatozoa for assisted fertilization (ejaculated and surgically retrieved). Those groups were assessed for SPL rates.

Results: Among the 3125 (59.25) conception cycles, 305 (9.7%) were diagnosed as SPL. There was no difference in SPL rate among E2 percentile groups. Women older than 35 years of age had significantly higher rate of SPL compared to younger women. There was also no difference in SPL rate among pregnancies in whom surgically retrieved spermatozoa used or ejaculated spermatozoa used for assisted fertilization.

Conclusion: Our results demonstrated that SPL rate was not influenced by the levels of E2 during COH or the origin of spermatozoa used for assisted fertilization. However, maternal age was found to be detrimental for SPL.

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Authors and Affiliations

  1. Bahceci Women Health Care Center and German Hospital in Istanbul, Azer Is Merkezi 44/17 Kat 5, Abdi Ipekci Cad Nisantasi, 80200, Istanbul, Turkey

    Ulun Ulug, Suleyman Tosun, Esra Aksoy Jozwiak, Ali Mesut, Alper Sismanoglu & Mustafa Bahceci

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  1. Ulun Ulug
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  2. Suleyman Tosun
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  3. Esra Aksoy Jozwiak
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  4. Ali Mesut
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  5. Alper Sismanoglu
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  6. Mustafa Bahceci
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Correspondence to Mustafa Bahceci.

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Ulug, U., Tosun, S., Jozwiak, E.A. et al. Subclinical Pregnancy Losses Among Women Undergoing In-Vitro Fertilization With ICSI. J Assist Reprod Genet 23, 261–267 (2006). https://doi.org/10.1007/s10815-006-9038-0

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  • DOI: https://doi.org/10.1007/s10815-006-9038-0

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