Purpose : To compare the effectiveness of double IUI with single IUI in male factor and idiopathic infertility patients undergoing controlled ovarian hyperstimulation (COH).
Methods : A prospective randomized study of 1257 COH-IUI cycles was performed. Total 1270 patients with mild or moderate male factor infertility (n = 776) and idiopathic infertility (n = 494) were enrolled in this study, and 767 with male factor infertility and 490 with idiopathic infertility completed clomiphene citrate (CC)/human menopausal gonadotrophin (hMG) COH cycles and IUI. Categorized on the basis of the causes of infertility (male factor, M; idiopathic infertility, I), patients were randomized into one of the following groups: Single IUI group (M1/I1) received single insemination 34 h post hCG administration, and double IUI group (M2/I2) received two inseminations 18–24 and 36–48 h post hCG injection, respectively.
Results : The overall pregnancy rates were 15.43%. Pregnancy rate for single and double IUI group was 11.06 and 19.87% (p < 0.05), respectively. There was a significant statistical difference in cycle fecundity between M1 and M2 group (11.34% vs. 24.93%, p < 0.05), and between I2 and M2 group (11.93% vs. 24.93%, p < 0.05), but there was no significant difference between I1 and I2 (10.53% vs. 11.93%, p > 0.05).
Conclusions : Double IUI increases the pregnancy rate significantly in patients with male factor infertility, and single IUI acts as efficient as double IUI in patients with idiopathic infertility.
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The authors thank Central South University for supporting the study by providing Wei Liu ‘The Grands for Young Promising Teachers.’
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Liu, W., Gong, F., Luo, K. et al. Comparing the pregnancy rates of one versus two intrauterine inseminations (IUIs) in male factor and idiopathic infertility. J Assist Reprod Genet 23, 75–79 (2006). https://doi.org/10.1007/s10815-005-9017-x
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DOI: https://doi.org/10.1007/s10815-005-9017-x