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A Study of the Thermal Degradation of Amoxicillin Trihydrate Using Raman Spectroscopy and High-Performance Liquid Chromatography

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Journal of Applied Spectroscopy Aims and scope

High-performance liquid chromatography (HPLC) and Raman spectroscopy have been used to study the thermal degradation of amoxicillin trihydrate. Heating this compound at 60°C for 6 h led to an increase in the impurity contents, each not exceeding 1%. HPLC and Raman spectroscopy can be used to evaluate the quality of an amoxicillin sample obtained after thermal degradation at 80°C.

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Authors and Affiliations

  1. A. M. Butlerov Chemical Institute, Kazan (Volga Region) Federal University, Kazan, Russia

    R. R. Davletshin & A. N. Sedov

  2. Yaroslavl Branch of the Federal State Budgetary Institution “Information and Methodological Center for Expert Evaluation, Recording and Analysis of Circulation of Medical Products of the Federal Service for Surveillance in Healthcare, Yaroslavl, Russia

    R. R. Galeev & I. R. Aryslanov

  3. FSBI “Information and Methodological Center for Expert Evaluation, Recording and Analysis of Circulation of Medical Products of Roszdravnadzor”, Moscow, Russia

    E. V. Galeeva

Authors
  1. R. R. Davletshin
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  2. R. R. Galeev
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  3. I. R. Aryslanov
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  4. E. V. Galeeva
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  5. A. N. Sedov
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Correspondence to R. R. Davletshin.

Additional information

Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 91, No. 2, pp. 257–263, March–April, 2024.

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Davletshin, R.R., Galeev, R.R., Aryslanov, I.R. et al. A Study of the Thermal Degradation of Amoxicillin Trihydrate Using Raman Spectroscopy and High-Performance Liquid Chromatography. J Appl Spectrosc 91, 335–341 (2024). https://doi.org/10.1007/s10812-024-01725-9

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  • DOI: https://doi.org/10.1007/s10812-024-01725-9

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