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Derivative Spectrophotometric Methods for Determination of Solifenacin Succinate in Bulk and in Tablet Formulation

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Journal of Applied Spectroscopy Aims and scope

Rapid, sensitive, reproducible, and cost-effective zero-order and first-order derivative spectrophotometric method has been developed for the quantification of solifenacin succinate in bulk and its tablet formulation. Preliminary spectrophotometric determination of the drug was carried out in 0.1 N HCl, methanol, and in phosphate buffer pH 2.0 with a total of thirty-three parametric variations. The selected method with three parametric variations employing peak–zero (P–0) and peak–peak (P–P) techniques was assessed for stability, indicating a potential for force-degraded solutions. The method was validated in accordance with the ICH guidelines with respect to linearity, accuracy, precision, limit of detection (LOD), limit of quantification (LOQ), and robustness. Excellent linearity was noted in a concentration range of 1.0–80.0 μg/mL for all three method variants. Limits of detection for the proposed method ranged from 0.03–0.16 μg/mL and limits of quantitation were found to be in the range of 0.09–0.48 μg/mL, respectively. Excellent recovery of the drug was obtained from its marketed tablet formulation with the proposed method.

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Authors and Affiliations

  1. University Institute of Pharmaceutical Sciences, UGC Center of Advanced Study, Panjab University, Chandigarh, India

    Pooja Singh & Alka Bali

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  1. Pooja Singh
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  2. Alka Bali
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Correspondence to Alka Bali.

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Published in Zhurnal Prikladnoi Spektroskopii, Vol. 89, No. 6, pp. 830–836, November–December, 2022.

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Singh, P., Bali, A. Derivative Spectrophotometric Methods for Determination of Solifenacin Succinate in Bulk and in Tablet Formulation. J Appl Spectrosc 89, 1085–1091 (2023). https://doi.org/10.1007/s10812-023-01471-4

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  • DOI: https://doi.org/10.1007/s10812-023-01471-4

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