A sensitive, reproducible, and cost-effective spectrofluorimetric method was developed for the quantification of solifenacin succinate in bulk and its tablet formulation. The method was validated in accordance with the International Conference on Harmonization guidelines with respect to linearity, accuracy, precision, limit of detection, limit of quantification, and robustness. Excellent linearity was noted in the concentration range of 15.0–95.0 μg/mL with a correlation coefficient (r2) of 0.9961. The limits of detection and quantitation for the proposed method were found to be 1.19 and 3.62 μg/mL, respectively. Excellent recovery of the drug was obtained from its marketed tablet formulation with the proposed method.
Similar content being viewed by others
References
D. Robinson and L. Cardozo, Expert Rev. Clin. Pharmacol., 2, No. 3, 239–253 (2009).
R. Basra and C. Kelleher, Ther. Clin Risk Manag., 4, No. 1, 117–128 (2008).
D. Robinson and L. Cardozo, Therapy, 8, No. 6, 691–701 (2011).
N. Desai, S. S. Hussen, K. Arumugam, S. G. Vasanthraju, and K. Udupan, Int. J. Pharm. Pharm. Sci., 3, No. 1, 70–74 (2011).
R. Reddy, R. Sidhaye, A. Sherikar, M. Nadre, and M. Krishna, Pharmacophore, 8, No. 2, 11–23 (2017).
R. P. Shaik, S. B. Puttagunta, C. K. Bannoth, and B. S. R. Challa, ISRN Anal. Chem, 1–5 (2014).
V. Bhavana, H. T. Kumar, S. Y. Rao, and V. P. K. Rao, Asian J. Pharm. Anal., 9, No. 3, 118–122 (2019).
M. C. Damle and P. C. Rokade, Int. J. Pharm. Sci. Res., 8, No. 4, 218–222 (2016).
S. R. Krishna, B. M. Rao, and N. S. Rao, J. Chromatogr. Sci., 48, No. 10, 807–810 (2010).
H. Terada, Y. Hattori, T. Sasaki, and M. Otsuka, Int. J. Pharm., 565, 325–332 (2019).
B. Rakesh, P. Bhargavi, S. R. Reddy, and A. A. Kumar, Int. J. Pharm. Pharm. Sci., 6, No. 10, 190–193 (2014).
K. M. Madhu and C. Rambabu, Rasayan J. Chem., 10, No. 4, 1068–1074 (2017).
L. Singh and L. S. Nanda, Pharm. Methods, 2, No. 1, 21–24 (2011).
G. D. Teja, C. D. Dasu, B. P. Srinivasa, and P. Ravisankar, J. Chem. Pharm. Sci., 6, No. 3, 195–198 (2013).
P. Dhara, N. Saiyed, and S. Desai, Int. J. Pharm. Pharm. Res., 2, No. 4, 175–183 (2015).
Y. Srinivasarao, H. Kumar, P. Chiranjivi, and V. K. Rao, Indian J. Pharm. Sci., 83, No. 2, 331–335 (2021).
B. V. Reddy, B. S. Reddy, N. V. V. S. S. Raman, K. S. Reddy, and C. Rambabu, J. Chem., 1–10 (2013).
D. Desai, G. Patel, N. Shukla, and S. Rajput, Acta Chromatogr., 24, No. 3, 399–418 (2012).
M. A. Tantawy, S. A. Weshahy, M. Wadie, and M. R. Rezk, Anal. Methods, 12, No. 26, 3368–3375 (2020).
D. K. Singh, M. Kurmi, T. Handa, and S. Singh, Chromatographia, 79, Nos. 3–4, 159–168 (2016).
J. Macek, P. Ptáček, and J. J. Klíma, J. Chromatogr. B, 878, No. 31, 3327–3330 (2010).
W. G. Ammari, Trop. J. Pharm. Res., 14, No. 5, 845–851 (2015).
T. C. Akman and Y. Kadıoğlu, Bioorg. Med. Chem., 2, 15–23 (2019).
T. Yanagihara, T. Aoki, Y. Soeishi, T. Iwatsubo, and H. Kamimura, J. Chromatogr. B, 859, No. 2, 241–245 (2007).
S. B. Puttagunta, R. P. Shaik, C. K. Bannoth, B. S. R. Challa, and B. Z. Awen, J. Anal. Sci. Technol., 5, No. 1, 1–8 (2014).
ICH Q2 (R1), Validation of analytical procedures: Test and methodology, In International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use, Geneva, Switzerland, pp. 1–13 (2005).
Author information
Authors and Affiliations
Corresponding author
Additional information
Abstract of article is published in Zhurnal Prikladnoi Spektroskopii, Vol. 89, No. 4, p. 593, July–August, 2022.
Rights and permissions
Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Singh, P., Bali, A. Spectrofluorimetric Method for Determination of Solifenacin Succinate in Bulk and in Tablet Formulation. J Appl Spectrosc 89, 768–772 (2022). https://doi.org/10.1007/s10812-022-01423-4
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10812-022-01423-4