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Cytotoxicity and DNA Binding Ability of Two Novel Gold(III) Complexes

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Journal of Applied Spectroscopy Aims and scope

The interaction of two gold(III) complexes [Au(phen)Cl2](Cl) (1) and [Au(pdon)Cl2](Cl) (2) with calf thymus-DNA (CT-DNA) has been investigated by absorption and fluorescence emission. Both complexes 1 and 2 show medium interaction ability with CT–DNA with the intrinsic binding constants Kb of 4.98 × 105 and 1.98 × 105 M–1 at room temperature, respectively, which is the same as earlier reports for typical classical intercalators. Moreover, complex 1 demonstrates a better antitumor effect on the tested cancer cells.

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Authors and Affiliations

  1. School of Pharmacy, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers’ University, Yancheng, 224051, Jiangsu, China

    G. Gu, C. Chen, Q. Wang, Z. Gao & M. Xu

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  1. G. Gu
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  2. C. Chen
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  3. Q. Wang
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  4. Z. Gao
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  5. M. Xu
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Correspondence to Q. Wang.

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Published in Zhurnal Prikladnoi Spektroskopii, Vol. 86, No. 4, pp. 563–568, July–August, 2019.

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Gu, G., Chen, C., Wang, Q. et al. Cytotoxicity and DNA Binding Ability of Two Novel Gold(III) Complexes. J Appl Spectrosc 86, 618–622 (2019). https://doi.org/10.1007/s10812-019-00868-4

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  • DOI: https://doi.org/10.1007/s10812-019-00868-4

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