Skip to main content
SpringerLink
Log in

Quantitative Monitoring of Cefradine in Human Urine Using a Luminol/Sulfobutylether–β-Cyclodextrin Chemiluminescence System

  • Published:
Journal of Applied Spectroscopy Aims and scope

In this paper, a sensitive, rapid, and simple flow-injection chemiluminescence (FI-CL) technique is described for determining cefradine in human urine and capsule samples at the picogram level. The results show that cefradine within 0.1–100.0 nmol/L quantitatively quenches the CL intensity of the luminol/sulfo butylether–β-cyclodextrin (SBE–β-CD) system, with a relative correlation coefficient r of 0.9931. Subsequently, the possible mechanism for the quenching phenomenon is discussed in detail using the FI-CL and molecular docking methods. The proposed CL method, with a detection limit of 0.03 nmol/L (3σ) and relative standard deviations <3.0% (N = 7), is then implemented to monitor the excretion of cefradine in human urine. After orally administration, the cefradine reaches a maximum value of 1.37 ± 0.02 mg/mL at 2.0 h in urine, and the total excretion is 4.41 ± 0.03 mg/mL within 8.0 h. The absorption rate constant ka, the elimination rate constant ke, and the half-life t1/2 are 0.670 ± 0.008 h−1, 0.744 ± 0.005 h−1, and 0.93 ± 0.05 h, respectively.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. M. El-Kosasy, S. M. Riad, L. E. Abd El-Fattah, and S. Abd El-Kader Ahmad, Water Res., 37, 1769–1775 (2003).

    Article  Google Scholar 

  2. U. K. Aman, I. Javeid, S. Khattak, and N. Saquib, Drug. Metab. Toxicol., 4, 1 (2013).

    Google Scholar 

  3. X. W. Hu, Y. L. Wang, C. Xie, G. Wang, and H. X. Hao, J. Chem. Eng. Data, 58, No. 7, 2028–2034 (2013).

    Article  Google Scholar 

  4. A. Fakhri, S. Rashidi, M. Asif, I. Tyagi, S. Agarwal, and V. K. Gupta, J. Mol. Liq., 215, 269–275 (2016).

    Article  Google Scholar 

  5. M. A. Omar, O. H. Abdelmageed, and T. Z. Attia, Int. J. Anal. Chem., 1 (2009).

  6. H. Zhang, L. L. Wu, Q. M. Li, and X. Z. Du, Chin. Chem. Lett., 19, 1470–1474 (2008).

    Article  Google Scholar 

  7. S. J. Choi, J. H. Ryu, H. W. Lee, M. J. Lee, J. H. Seo, and S. K. K.T. Tak, J. Chromatogr. B, 877, No. 31, 4059–4064 (2009).

    Article  Google Scholar 

  8. W. Q. Li, H. Y. Shen, Y.H. Hong, Y. Zhang, F. Yuan, and F. Zhang, J. Chromatogr. B, 1022, 298–307 (2016).

    Article  Google Scholar 

  9. V. M. Johnson, J. P. Allanson, and R. C. Causon, J. Chromatogr. B, 740, 71–80 (2000).

    Article  Google Scholar 

  10. A. R. Solangi, S. Q. Memon, M. Y. Khuhawar, and M. I. Bhanger, Acta Chromatogr., 19, 81–96 (2007).

    Google Scholar 

  11. M. A. Omar, O. H. Abdelmageed, and T. Z. Attia, Talanta, 77, 1394–1404 (2009).

    Article  Google Scholar 

  12. C. Lu, N. Zhang, J. G. Li, and Q. Q. Li, Talanta, 81, Nos. 1–2, 698–702 (2010).

    Article  Google Scholar 

  13. A. Khataee, R. Lotfi , A. Hasanzadeh, M. Iranifam, and S. W. Joo, Spectrochim. Acta A, 157, No. 15, 88–95 (2016).

    Article  ADS  Google Scholar 

  14. A. Khataee, R. Lotfi , A. Hasanzadeh, M. Iranifam, M. Zarei, and S. W. Joo, Spectrochim. Acta A, 153, No. 15, 273–280 (2016).

    Article  ADS  Google Scholar 

  15. Z. F. Fu, G. K. Li, and Y. F. Hu, Chin. J. Anal. Chem., 43, No. 9, 1322–1328 (2015).

    Article  Google Scholar 

  16. J. T. Cao, H. Wang, and Y. M. Liu, Spectrochim. Acta A, 140, No. 5, 162–165 (2015).

    Article  ADS  Google Scholar 

  17. J. X. Du and H. Li, Appl. Spectrosc., 64, 1154–1159 (2010).

    Article  ADS  Google Scholar 

  18. W. Liu, Z. J. Zhang, and Z. Q. Liu, Anal. Chim. Acta, 592, 187–192 (2007).

    Article  Google Scholar 

  19. J. Zhong, Z. G. Shen, Y. Yang, and J. F. Chen, Int. J. Pharm., 301, 286–293 (2005).

    Article  Google Scholar 

  20. X. H. Zhang, L. Q. Su, and Y. H. Wang, Chem. Eng., 10, 60 (2006).

    Google Scholar 

  21. V. Zia, R. A. Rajewski, and V. J. Stella, Pharm. Res., 18, 667–673 (2001).

    Article  Google Scholar 

  22. A. A. Mahmoud, G. S. El-Feky, R. Kamel, and G. E. A. Awad, Int. J. Pharm., 413, 229–236 (2011).

    Article  Google Scholar 

  23. X. Y. Xiong, X. F. Zhao, and Z. H. Song, Anal. Biochem., 460, No. 1, 54–60 (2014).

    Article  Google Scholar 

  24. M. Stojanov, H. M. Nielsen, and K. L. Larsen, Int. J. Pharm., 422, Nos. 1–2, 349–355 (2012).

    Article  Google Scholar 

  25. L. L. Chen, L. C. Chen, and Y. J. W. I. Shu, J. Pharm. Sci., 101, 2883 (2012).

    Article  Google Scholar 

  26. C. J. Zhou, L. F. Li, Y. Liu, S. P. Wen, Y. E. Guo, and X. G. Niu, Adv. Mater. Res., 455–456, 1177 (2012).

    Article  Google Scholar 

  27. C. Aramă, C. Nicolescu, A. Nedelcu, and C. M. Monciu, J. Incl. Phenom. Macrocycl. Chem., 70, Nos. 3–4, 421–428 (2011).

    Article  Google Scholar 

  28. M. X. Shen, H. R. Lv, and Z. H. Song, B. Kor. Chem. Soc., 34, No. 11, 3199–3205 (2013).

    Article  Google Scholar 

  29. M. X. Shen, M. Wu, X. J. Tan, and Z. H. Song, Instrum. Sci. Technol., 42, No. 1, 46–58 (2014).

    Article  Google Scholar 

  30. M. Wu, D. H. Chen, and Z. H. Song, Spectrochim. Acta A: Mol. Biomol. Spectrosc., 96, 1 (2012).

    Article  ADS  Google Scholar 

  31. J. R. Lakowicz, Principles of Fluorescence Spectroscopy, 2nd ed., Springer, New York (1999).

    Book  Google Scholar 

  32. P. D. Ross and S. Subramanian, Biochemistry, 20, No. 11, 3096–3102 (1981).

    Article  Google Scholar 

  33. M. Wu, Z. H. Song, and J. J. Zhang, Drug. Metab. Lett., 5, No. 4, 259–266 (2011).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Earth Environment, Chinese Academy of Sciences, No . 97 Yanxiang Road, Xi’an, 710061, Shaanxi, China

    M. X. Shen

  2. College of Earth Sciences and Land Resources, Chang’an University, Xi’an, China

    X. J. Tan

  3. College of Chemistry and Materials Science, Northwest University, Xi’an, 710069, China

    Zh. H. Song

Authors
  1. M. X. Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. X. J. Tan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zh. H. Song
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. X. Shen.

Additional information

Published in Zhurnal Prikladnoi Spektroskopii, Vol. 85, No. 2, pp. 313–320, March–April, 2018.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shen, M.X., Tan, X.J. & Song, Z.H. Quantitative Monitoring of Cefradine in Human Urine Using a Luminol/Sulfobutylether–β-Cyclodextrin Chemiluminescence System. J Appl Spectrosc 85, 327–334 (2018). https://doi.org/10.1007/s10812-018-0652-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10812-018-0652-2

Keywords

Search

Navigation