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A sensitive chemiluminescence method for the determination of celecoxib in pharmaceutical and biological samples

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Abstract

A simple and sensitive chemiluminometric method was developed for the determination of celecoxib, a nonsteroidal anti-inflammatory drug. It is based on the sensitization of Ce(IV)-Na2SO3 chemiluminescence reaction by celecoxib in the presence of Tb(III) ions. The mechanism of chemiluminescence reaction was studied by obtaining fluorescence and chemiluminescence spectra. The effects of various chemical parameters on chemiluminescence intensity were investigated and optimized. Under the optimum conditions, a linear relationship was obtained between the enhanced chemiluminescence intensity and the concentration of celecoxib in the range of 0.01–0.15 μg/mL, with a limit of detection of 2.5 ng/mL. Study of interferences confirmed the selectivity of the developed method for analysis of pharmaceutical and biological samples. The method was applied to the determination of celecoxib in pharmaceutical formulations and human plasma samples, and also to dissolution studies with satisfactory results.

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References

  1. Katzung, B.G., Trevor, A.J., and Masters, S.B., Basic and Clinical Pharmacology, New York: McGraw-Hill, 2006.

    Google Scholar 

  2. Reddy, B.S., Hirose, Y., Lubet, R., Steele, V., Kelloff, G., Paulson, S., Seibert, K., and Rao, C.V., and Cancer Res., 2000, vol. 60, no. 2, p. 293.

    CAS  Google Scholar 

  3. Leese, P.T., Hubbard, R.C., Karim, A., Isakson, P.C., Yu, S.S., and Geis, G.S., J. Clin. Pharmacol., 2000, vol. 40, no. 2, p. 124.

    Article  CAS  Google Scholar 

  4. Steinbach, G., Lynch, P.M., Phillips, R.K., Wallace, M.H., Hawk, E., and Gordon, G.B., Engl. J. Med., 2000, vol. 342, no. 26, p. 1946.

    Article  CAS  Google Scholar 

  5. Davies, N.M., McLachlan, A.J., Day, R.O., and Williams, K.M., Clin. Pharmacokinet., 2000, vol. 38, no. 3, p. 225.

    Article  CAS  Google Scholar 

  6. Saha, R., Sajeev, C., Jadhav, P., Patil, S., and Srinivasan, N., J. Pharm. Biomed. Anal., 2002, vol. 28, nos. 3–4, p. 741.

    Article  CAS  Google Scholar 

  7. Bebawy, L., Moustafa, A., and Abo-Talib, N., J. Pharm. Biomed. Anal., 2002, vol. 27, no. 5, p. 779.

    Article  CAS  Google Scholar 

  8. Damiani, P., Bearzotti, M., and Cabezon, M.A., Anal. Bioanal. Chem., 2003, vol. 376, no. 7, p. 1141.

    Article  CAS  Google Scholar 

  9. Manzoori, J.L., Abdolmohammad-Zadeh, H., and Amjadi, M., Il Farmaco, 2005, vol. 60, nos. 6–7, p. 575.

    Article  CAS  Google Scholar 

  10. Ghoneim, M. and Beltagi, A., Talanta, 2003, vol. 60, no. 5, p. 911.

    Article  CAS  Google Scholar 

  11. Jalalizadeh, H., Amini, M., Ziaee, V., Safa, A., Farsam, H., and Shafiee, A., J. Pharm. Biomed. Anal., 2004, vol. 35, no. 3, p. 665.

    Article  CAS  Google Scholar 

  12. Schonberger, F., Heinkele, G., Murdter, T.E., Brenner, S., Klotz, U., and Hofmann, U., J. Chromatogr. B, 2002, vol. 768, no. 2, p. 255.

    Article  CAS  Google Scholar 

  13. Rose, M.J., Woolf, E.J., and Matuszewski, B.K., J. Chromatogr. B, 2000, vol. 738, no. 2, p. 377.

    Article  CAS  Google Scholar 

  14. Hashem, H., Trundelberg, C., and Jira, T., Chromatografia, 2010, vol. 71, no. 1, p. 91.

    Article  CAS  Google Scholar 

  15. Abdel-Hamid, M., Novotny, L., and Hamza, H., J. Chromatogr. B, 2001, vol. 753, no. 2, p. 401.

    Article  CAS  Google Scholar 

  16. Park, M.S., Shim, W.S., Yim, S.V., and Lee, K.T., J. Chromatogr. B, 2012, vol. 902, p. 137.

    Article  CAS  Google Scholar 

  17. Ptacek, P., Klima, J., and Macek, J., J. Chromatogr. B, 2012, vol. 899, p. 163.

    Article  CAS  Google Scholar 

  18. Chow, H.S., Anavy, N., Salazar, D., Frank, D.H., and Alberts, D.S., J. Pharm. Biomed. Anal., 2004, vol. 34, no. 1, p. 167.

    Article  CAS  Google Scholar 

  19. Srinivasu, M., Sreenivas Rao, D., and Reddy, G.O., J. Pharm. Biomed. Anal., 2002, vol. 28, nos. 3–4, p. 493.

    Article  CAS  Google Scholar 

  20. Garcia-Campana, A.M. and Baeyens, W.R.G., Chemiluminescence in Analytical Chemistry, New York: Marcel Dekker, 2001.

    Google Scholar 

  21. Georges, J., Analyst, 1993, vol. 118, no. 12, p. 1481.

    Article  CAS  Google Scholar 

  22. Ocana, J.A., Barragan, F.J., Callejon, M., and De la Rosa, F., Microkhim. Acta, 2004, vol. 144, no. 1, p. 207.

    Article  CAS  Google Scholar 

  23. Li, D., Du, J., and Lu, J., Microkhim. Acta, 2008, vol. 161, nos. 1s-2, p. 169.

    Article  CAS  Google Scholar 

  24. Zhao, F., Qi, Y., and Xiong, W., Bull. Korean Chem. Soc., 2012, vol. 33, p. 204.

    Article  CAS  Google Scholar 

  25. Du, J., Li, D., and Lu, J., Luminescence, 2010, vol. 25, no. 1, p. 76.

    CAS  Google Scholar 

  26. Takeuchi, K. and Ibusuki, T., Anal. Chim. Acta, 1985, vol. 174, p. 359.

    Article  CAS  Google Scholar 

  27. Capitan-Vallvey, L., Valencia Miron, M., and Acosta Acosta, R., Talanta, 2000, vol. 51, no. 6, p. 1155.

    Article  CAS  Google Scholar 

  28. Zhang, S., Zhuang, Y., and Ju, H., Anal. Lett., 2004, vol. 37, no. 1, p. 143.

    Article  CAS  Google Scholar 

  29. Xie, Z., Ouyang, X., Guo, L., Lin, X., Chen, G., Xie, Z., Ouyang, X., Guo, L., Lin, X., and Chen, G., Luminescence, 2005, vol. 20, no. 3, p. 226.

    Article  CAS  Google Scholar 

  30. Nie, L.H., Zhao, H.C., Wang, X., Yi, L., Lu, Y., Jin, L.P., and Ma, H.M., Anal. Bioanal. Chem., 2002, vol. 374, nos. 7–8, p. 1187.

    Article  CAS  Google Scholar 

  31. Ocana, J., Callejon, M., Barragan, F., and De la Rosa, F., Anal. Chim. Acta, 2003, vol. 482, no. 1, p. 105.

    Article  CAS  Google Scholar 

  32. Lian, N., Zhao, H., Sun, C., Chen, S., Lu, Y., and Jin, L., Microchem. J., 2003, vol. 74, no. 3, p. 223.

    Article  CAS  Google Scholar 

  33. Adcock, J.L., Francis, P.S., and Barnett, N.W., Anal. Chim. Acta, 2009, vol. 652, nos. 1s-2, p. 303.

    Article  CAS  Google Scholar 

  34. Huang, Y., Zhang, C., Zhang, X., and Zhang, Z., Anal. Chim. Acta, 1999, vol. 391, no. 1, p. 95.

    Article  CAS  Google Scholar 

  35. Sun, H., Li, L., and Chen, X., Anal. Chim. Acta, 2006, vol. 576, no. 2, p. 192.

    Article  CAS  Google Scholar 

  36. Guidance for Insudtry Dissolution of Immediate Release Solid Oral Dosage Forms, US FDA, 1997.

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, 5166616471, Iran

    Tooba Hallaj, Mohammad Amjadi, Jamshid L. Manzoori & Mohammad H. Sorouraddin

Authors
  1. Tooba Hallaj
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  2. Mohammad Amjadi
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  3. Jamshid L. Manzoori
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  4. Mohammad H. Sorouraddin
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Correspondence to Mohammad Amjadi.

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Hallaj, T., Amjadi, M., Manzoori, J.L. et al. A sensitive chemiluminescence method for the determination of celecoxib in pharmaceutical and biological samples. J Anal Chem 70, 166–172 (2015). https://doi.org/10.1134/S1061934815020203

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  • DOI: https://doi.org/10.1134/S1061934815020203

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