Abstract
Social engagement, pretend play, and concern for another’s distress represent fundamental features of typical social-emotional development in the second year. Children with autism spectrum disorder (ASD) display delays and deficits in these areas, and research on toddlers at heightened risk for ASD (HR; younger siblings of children with ASD) indicates these deficits may be apparent in toddlerhood. Prior research has examined these aspects of social-emotional development individually in HR toddlers. The present paper examines them jointly as predictors of ASD. We show that social engagement, pretend play, and empathic concern at 22-months each contribute uniquely to predicting later ASD diagnosis with high specificity and moderate sensitivity. Results have important implications for early diagnosis and intervention in young children with ASD.
Similar content being viewed by others
Notes
Analyses were originally run without doing this second standardization of composite scores; however, this made interpretation of results significantly more cumbersome. The re-standardizing of composite scores does not change any results, but allows us to interpret one-unit differences as one standard deviation differences, making results much more interpretable.
Note that the odds ratios reported in Table 3 are the odds of having ASD given scores 1 SD higher than the mean. In order to report on the odds ratio of having ASD given scores 1 SD lower than the mean, we took the inverse of the odds ratio (1/odds ratio).
References
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders : DSM-IV-TR. Washington, DC: American Psychiatric Association.
Bacon, A. L., Fein, D., Morris, R., Waterhouse, L., & Allen, D. (1998). The responses of autistic children to the distress of others. Journal of Autism and Developmental Disorders, 28(2), 129–142. https://doi.org/10.1023/A:1026040615628.
Belsky, J., & Most, R. K. (1981). From exploration to play: A cross-sectional study of infant free play behavior. Developmental Psychology, 17(5), 630–639. https://doi.org/10.1037/0012-1649.17.5.630.
Bennett, M., & Goodall, E. (2016). A meta-analysis of DSM-5 autism diagnoses in relation to DSM-IV and DSM-IV-TR. Review Journal of Autism and Developmental Disorders, 3(2), 119–124. https://doi.org/10.1007/s40489-016-0070-4.
Brian, J. A., Smith, I. M., Zwaigenbaum, L., Roberts, W., & Bryson, S. E. (2016). The social ABCs caregiver-mediated intervention for toddlers with autism spectrum disorder: Feasibility, acceptability, and evidence of promise from a multisite study. Autism Research, 9(8), 899–912. https://doi.org/10.1002/aur.1582.
Brownell, C. A., & Carriger, M. S. (1990). Changes in cooperation and self-other differentiation during the second year. Child Development, 61(4), 1164–1174. https://doi.org/10.1111/j.1467-8624.1990.tb02850.x.
Brownell, C. A., & Kopp, C. B. (2007). Transitions in toddler socioemotional development. In C. A. Brownell & C. B. Kopp (Eds.), Socioemotional development in the toddler years: Transitions and transformations (pp. 1–40). New York: Guilford Publications.
Campbell, S. B., Leezenbaum, N. B., Mahoney, A. S., Day, T. N., & Schmidt, E. N. (2014). Social engagement with parents in 11-month-old siblings at high and low genetic risk for autism spectrum disorder. Autism, 19(8), 915–924. https://doi.org/10.1177/1362361314555146.
Campbell, S. B., Leezenbaum, N. B., Mahoney, A. S., Moore, E. L., & Brownell, C. A. (2016). Pretend play and social engagement in toddlers at high and low genetic risk for autism spectrum disorder. Journal of Autism and Developmental Disorders, 47(9), 2609-2702.
Campbell, S. B., Leezenbaum, N. B., Schmidt, E. N., Day, T. N., & Brownell, C. A. (2015). Concern for another’s distress in toddlers at high and low genetic risk for autism spectrum disorder. Journal of Autism and Developmental Disorders, 45(11), 3594–3605.
Campbell, S. B., Mahoney, A. S., Northrup, J., Moore, E. L., Leezenbaum, N. B., & Brownell, C. A. (2018). Developmental changes in pretend play from 22-to 34-months in younger siblings of children with autism spectrum disorder. Journal of abnormal child psychology, 46(3), 639–654.
Campbell, S. B., Moore, E. L., Northrup, J., & Brownell, C. A. (2017). Developmental changes in empathic concern and self-understanding in toddlers at genetic risk for autism spectrum disorder. Journal of Autism and Developmental Disorders, 47(9), 2690-2702.
Charman, T., Swettenham, J., Baron-Cohen, S., Cox, A., Baird, G., & Drew, A. (1997). Infants with autism: An investigation of empathy, pretend play, joint attention, and imitation. Developmental Psychology, 33, 781–789. https://doi.org/10.1037/0012-1649.33.5.781.
Christensen, L., Hutman, T., Rozga, A., Young, G. S., Ozonoff, S., Rogers, S. J., et al. (2010). Play and developmental outcomes in infant siblings of children with autism. Journal of Autism and Developmental Disorders, 40(8), 946–957.
Davidov, M., Zahn-Waxler, C., Roth-Hanania, R., & Knafo, A. (2013). Concern for others in the first year of life: Theory, evidence, and avenues for research. Child Development Perspectives, 7(2), 126–131. https://doi.org/10.1111/cdep.12028.
Dawson, G., Rogers, S., Munson, J., Smith, M., Winter, J., Greenson, J., et al. (2010). Randomized, controlled trial of an intervention for toddlers with autism: The early start Denver model. Pediatrics, 125(1), e17–e23. https://doi.org/10.1542/peds.2009-0958.
Fein, G. G. (1981). Pretend play in childhood: An integrative review. Child Development, 52(4), 1095–1118. https://doi.org/10.2307/1129497.
Feldman, R. (2007). Parent–infant synchrony and the construction of shared timing; physiological precursors, developmental outcomes, and risk conditions. Journal of Child Psychology and Psychiatry, 48(3–4), 329–354. https://doi.org/10.1111/j.1469-7610.2006.01701.x.
Gamliel, I., Yirmiya, N., & Sigman, M. (2007). The development of young siblings of children with autism from 4 to 54 months. Journal of Autism and Developmental Disorders, 37(1), 171–183. https://doi.org/10.1007/s10803-006-0341-5.
Garvey, C. (1990). Play. Cambridge, MA: Harvard University Press.
Gotham, K., Pickles, A., & Lord, C. (2009). Standardizing ADOS scores for a measure of severity in autism Spectrum disorders. Journal of Autism & Developmental Disorders, 39(5), 693–705. https://doi.org/10.1007/s10803-008-0674-3.
Hobson, R. P. (2007). Social relations, self-awareness, and symbolizing. In C. A. Brownell & C. B. Kopp (Eds.), Socioemotional development in the toddler years: Transitions and transformations (p. 423). New York: Guilford Press.
Hutman, T., Rozga, A., Delaurentis, A. D., Barnwell, J. M., Sugar, C. A., & Sigman, M. (2010). Response to distress in infants at risk for autism: A prospective longitudinal study. Journal of Child Psychology and Psychiatry and Allied Disciplines, 51(9), 1010–1020. https://doi.org/10.1111/j.1469-7610.2010.02270.x.
Iverson, J. M., Northrup, J. B., Leezenbaum, N. B., Parladé, M. V., Koterba, E. A., & West, K. L. (2018). Early gesture and vocabulary development in infant siblings of children with autism Spectrum disorder. Journal of Autism and Developmental Disorders, 48(1), 55–71. https://doi.org/10.1007/s10803-017-3297-8.
Jarrold, C. (2003). A review of research into pretend play in autism. Autism, 7(4), 379–390. https://doi.org/10.1177/1362361303007004004.
Lausberg, H., & Sloetjes, H. (2009). Coding gestural behavior with the NEUROGES-ELAN system. Behavior Research Methods, 41(3), 841–849. https://doi.org/10.3758/BRM.41.3.841.
Lillard, A. S. (2007). Pretend play in toddlers. In C. A. Brownell & C. B. Kopp (Eds.), Socioemotional development in the toddler years: Transitions and transformations (pp. 149–176). New York: Guilford Press.
Lord, C., & Rutter, M. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism & Developmental Disorders, 24(5), 659–685.
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule—Generic: A standard measure of social and communication deficits associated with the Spectrum of autism. Journal of Autism & Developmental Disorders, 30(3), 205–223. https://doi.org/10.1023/A:1005592401947.
Maenner, M. J., Shaw, K. A., & Baio, J., Washington, A., Patrick, M., DiRienzo, M. et al. (2020). Prevalence of autism spectrum disorder among children aged 8 years—autism and developmental disabilities monitoring network, 11 sites, United States, 2016. MMWR Surveillance Summaries, 69(4), 1–12.
Moore, C. (2007). Understanding self and others in the second year. In C. A. Brownell & C. B. Kopp (Eds.), Socioemotional development in the toddler years: Transitions and transformations (pp. 43–65). New York: Guilford press.
Mullen, E. M. (1995). Mullen scales of early learning. Pearson San Antonio, TX.
NICHD Early Child Care Research Network. (1999). Child care and mother–child interaction in the first three years of life. Developmental Psychology, 35(6), 1399–1413. https://doi.org/10.1037/0012-1649.35.6.1399.
Nichols, S. R., Svetlova, M., & Brownell, C. A. (2009). The role of social understanding and empathic disposition in young children’s responsiveness to distress in parents and peers. Cognition, Brain, Behavior : An Interdisciplinary Journal, 13(4), 449–478.
Nichols, S. R., Svetlova, M., & Brownell, C. A. (2015). Toddlers’ responses to infants’ negative emotions. Infancy, 20(1), 70–97. https://doi.org/10.1111/infa.12066.
Northrup, J. B., & Iverson, J. M. (2019). The development of mother-infant coordination across the first year of life. Developmental Psychology, 56(2), 221. https://doi.org/10.1037/dev0000867.
Ozonoff, S., Young, G. S., Carter, A., Messinger, D., Yirmiya, N., Zwaigenbaum, L., et al. (2011). Recurrence risk for autism spectrum disorders: A baby siblings research consortium study. Pediatrics, 128(3), e488–e495. https://doi.org/10.1542/peds.2010-2825.
Ozonoff, S., Young, G. S., Belding, A., Hill, M., Hill, A., Hutman, T., et al. (2014). The broader autism phenotype in infancy: When does it emerge? Journal of the American Academy of Child & Adolescent Psychiatry, 53(4), 398–407 e2.
Rogers, S. J., & Dawson, G. (2010). Early start Denver model for young children with autism: Promoting language, learning, and engagement. Guilford Press.
Sigman, M. D., Kasari, C., Kwon, J.-H., & Yirmiya, N. (1992). Responses to the negative emotions of others by autistic, mentally retarded, and Normal children. Child Development, 63(4), 796–807. https://doi.org/10.1111/j.1467-8624.1992.tb01662.x.
Szatmari, P., Chawarska, K., Dawson, G., Georgiades, S., Landa, R., Lord, C., et al. (2016). Prospective longitudinal studies of infant siblings of children with autism: Lessons learned and future directions. Journal of the American Academy of Child & Adolescent Psychiatry, 55(3), 179–187. https://doi.org/10.1016/j.jaac.2015.12.014.
Van Egeren, L. A., Barratt, M. S., & Roach, M. A. (2001). Mother–infant responsiveness: Timing, mutual regulation, and interactional context. Developmental Psychology, 37(5), 684–697. https://doi.org/10.1037/0012-1649.37.5.684.
Zahn-Waxler, C., Radke-Yarrow, M., Wagner, E., & Chapman, M. (1992). Development of concern for others. Developmental Psychology, 28(1), 126–136. https://doi.org/10.1037/0012-1649.28.1.126.
Zwaigenbaum, L., Bryson, S., Rogers, T., Roberts, W., Brian, J., & Szatmari, P. (2005). Behavioral manifestations of autism in the first year of life. International Journal of Developmental Neuroscience, 23(2-3 SPEC. ISS), 143–152. https://doi.org/10.1016/j.ijdevneu.2004.05.001.
Zwaigenbaum, L., Thurm, A., Stone, W., Baranek, G., Bryson, S., Iverson, J., et al. (2007). Studying the emergence of autism spectrum disorders in high-risk infants: Methodological and practical issues. Journal of Autism and Developmental Disorders, 37(3), 466–480. https://doi.org/10.1007/s10803-006-0179-x.
Zwaigenbaum, L., Bryson, S. E., Brian, J., Smith, I. M., Roberts, W., Szatmari, P., et al. (2016). Stability of diagnostic assessment for autism spectrum disorder between 18 and 36 months in a high-risk cohort. Autism Research, 9(7), 790–800. https://doi.org/10.1002/aur.1585.
Acknowledgments
This study was supported by the National Institute of Mental Health R01 MH091036 to Dr. Campbell. We thank Dr. Nancy Minshew, Dr. Mark Strauss, Dr. Carla Mazefsky, Dr. Holly Gastgeb, Ms. Stacey Becker, and the staff at Autism Center of Excellence, University of Pittsburgh for overseeing initial recruitment and assessment of participating families. The Autism Center of Excellence was supported by award number HD055748 (PI Minshew) from the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Recruitment was also facilitated by the Clinical and Translational Science Institute, supported by the National Institutes of Health through Grant Numbers UL1 RR024153 and UL1TR000005. Thanks are due to Taylor Day, Kristen Decker, Stephanie Fox, Phebe Lockyer, Amanda Mahoney, Elizabeth Moore, and Emily Schmidt for overseeing data collection and coding, and to Ari Fish, Rachel Fleming, Monica Kim, Kristen McMillen, Michelle Meyer, Jenna Obitko, and Amy Tavares for assisting with coding. Special thanks go to the parents and children who participated in this study.
Author information
Authors and Affiliations
Contributions
All authors contributed to the conceptualization and design of the current paper. SBC was responsible for the overall conduct and conceptualization of the larger longitudinal study. JBN analyzed the data and prepared an initial draft of the manuscript. All coauthors read, edited, and approved the manuscript.
Corresponding author
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Northrup, J.B., Leezenbaum, N.B. & Campbell, S.B. Observed Social Emotional Behavior at 22 Months Predicts a Later ASD Diagnosis in High-Risk Siblings. J Autism Dev Disord 51, 3187–3198 (2021). https://doi.org/10.1007/s10803-020-04789-6
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10803-020-04789-6