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Brief Report: Pupillometry, Visual Perception, and ASD Features in a Task-Switching Paradigm

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Abstract

We assessed the association between dynamic changes in pupil response in the context of visual perception and quantitative measures of the autism phenotype in healthy adults. Using Navon stimuli in a task-switching paradigm, participants were instructed to identify global or local information based on a cue. Multiple pupil response trajectories across conditions were identified. We combined trajectory patterns for global and local conditions and used data-driven methods to identify three distinct pupil trajectory sub-groups. We report higher scores on quantitative measures of autism features in individuals who demonstrated an increased change in pupil diameter across both conditions. Results demonstrate the use of individualized pupil response trajectories in order to quantitatively characterize visual perception associated with the broader autism phenotype (BAP).

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Fig. 1
Fig. 2

Notes

  1. While stimuli were presented for 5.5 s, due to consistent variability in Tobii eyetracking acquisitions (some having slightly over and/or under 330 samples taken across each 5.5 stimulus presentation) the initial 300 collected samples within each trial were used in analyses.

  2. We also explored potential differences in baseline pupil diameter between global and local conditions between our pupil trajectory groups. These analyses were carried out for all three pupil trajectory groups as well as comparisons between DIL and the collapsed, LF + NAR group. Results did not indicate significant differences in baseline pupil diameter associated with pupil trajectory group membership(p’s > 0.82, NS).

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Acknowledgments

The authors are grateful to Kayleigh M. Adamson for their help with recruitment and data collection. This study was funded by the Simons Foundation, SFARI Explorer Award #350225. We would like to extend our sincere gratitude to the individuals who participated in this study.

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Authors and Affiliations

  1. Geisinger Health System, Geisinger Autism & Developmental Medicine Institute (ADMI), 120 Hamm Drive, Suite 2A, Lewisburg, PA, 17837, USA

    Antoinette Sabatino DiCriscio & Vanessa Troiani

  2. Department of Biomedical & Translational Informatics, Geisinger, 100 N Academy Ave, Danville, PA, 17822, USA

    Yirui Hu

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  1. Antoinette Sabatino DiCriscio
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ASD and VT designed the research. ASD programmed the task and collected the data. YH and ASD completed data analysis. ASD, YH and VT interpreted the data. ASD drafted the manuscript. ASD, YH and VT critically revised the manuscript. All authors have read and approved the final version of the manuscript. All authors reviewed the manuscript.

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Correspondence to Antoinette Sabatino DiCriscio or Vanessa Troiani.

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DiCriscio, A.S., Hu, Y. & Troiani, V. Brief Report: Pupillometry, Visual Perception, and ASD Features in a Task-Switching Paradigm. J Autism Dev Disord 49, 5086–5099 (2019). https://doi.org/10.1007/s10803-019-04213-8

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