Abstract
Although the dexamethasone suppression test (DST) has limited use as a biomarker of depression given inadequate sensitivity and specificity, it marks prospective risk for suicide among adults. However, few studies have examined associations between the DST, suicidal ideation, and self-inflicted injury (SII) among adolescents, even though SII is the single best predictor of eventual suicide. We evaluated the DST as a correlate of suicidal ideation and retrospective reports of self-inflicted injury (SII) among adolescent girls, ages 13–17, with histories of depression (n = 28) or depression and self-harm (n = 29). Lower post-DST cortisol was associated with suicidal ideation and SII, over-and-above parent-reports and combined parent-/self-reports of internalizing and externalizing behavior. These findings are consistent with recent acquired capacity models of stress-related psychopathology in which hypothalamic-pituitary adrenal (HPA) axis function is altered through epigenetic/allostatic mechanisms among vulnerable individuals who incur adversity early in life.
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Research reported in this article was supported by National Institute of Mental Health grants MH074196 and MH63699.
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Beauchaine, T.P., Crowell, S.E. & Hsiao, R.C. Post-Dexamethasone Cortisol, Self-Inflicted Injury, and Suicidal Ideation Among Depressed Adolescent Girls. J Abnorm Child Psychol 43, 619–632 (2015). https://doi.org/10.1007/s10802-014-9933-2
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DOI: https://doi.org/10.1007/s10802-014-9933-2