Abstract
How school-associated behavioral problems in childhood and adolescence precede distinctive adult schizotypal symptoms was examined. Gender specific findings were explored. After 11.6 (SD = 3.1) years, 159 patients of the Department of Child and Adolescent Psychiatry of the University Medical Centre Utrecht, the Netherlands were reassessed for adult schizotypal symptoms. Severity of behavioral symptoms in childhood and adolescence using Teacher Report Form (TRF; Verhulst et al. 1997) and adult schizotypal symptoms using Schizotypal Personality Questionnaire-Revised (Raine in Schizophrenia Bulletin 17:555–564, 1991) were examined by Spearman’s bivariate correlations. Multiple regression analyses were performed to determine the combined predictive value of significant TRF subscales for schizotypal symptomatology. Moderation was tested by adding the interactions of gender with TRF subscales to the models. Disregarding gender, correlational analyses revealed that TRF Total problems, in specific thought problems, social problems, and attentional problems were associated with disorganized schizotypal symptoms in adult life. TRF thought problems was also associated with future positive schizotypal symptoms. When gender was taken into account, for boys only thought problems was associated with adult positive schizotypal symptoms, whereas for girls externalizing problems, specifically attentional and aggressive problems, were associated with the higher levels of adult disorganized schizotypal symptoms. Moderated regression analyses provided trend significant evidence confirming that in girls externalizing problems were positively associated with general and disorganized schizotypal symptoms. When using teachers as informants, it was found that juvenile behavioral abnormalities were differentially associated with type of adult schizotypal symptoms, with these associations being further modified by gender.
Similar content being viewed by others
References
Achenbach, T. M., McConaughy, S. H., & Howell, C. T. (1987). Child/adolescent behavioral and emotional problems: Implications of crossinformant correlations for situational specificity. Psychological Bulletin, 101, 213–232.
Addington, D., Addington, J., & Patten, S. (1996). Gender and affect in schizophrenia. Canadian Journal of Psychiatry, 41, 265–268.
American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders, 3rd revised ed. Washington DC: American Psychological Association Press.
Amminger, G. P., Pape, S., Rock, D., Roberts, S., Ott, S., Squires-Wheeler, E., et al. (1999). Relationship between childhood behavioral disturbance and later schizophrenia in the New York High-Risk project. American Journal of Psychiatry, 156, 525–530.
Arboleda, C., & Holzman, P. (1985). Thought disorder in children at risk for psychosis. Archives of General Psychiatry, 42, 1004–1013.
Arseneault, L., Moffitt, T. E., Caspi, A., Taylor, A., Rijsdijk, F. V., Jaffee, S. R., et al. (2003). Strong genetic effects on cross-situational antisocial behavior among 5-year-old children according to mother, teachers, examiner–observers, and twins’self-reports. Journal of Child Psychology and Psychiatry, 44, 832–848.
Ayalon, M., & Merom, H. (1985). The teacher interview. Schizophrenia Bulletin, 11, 117–120.
Bartels, M., Hudziak, J. J., Boomsma, D. I., Rietveld, M. J. H., Van Beijsterveldt, C. E. M., & Van den Oord, E. J. C. G. (2003). A study of parent ratings of internalizing and externalizing problem behavior in 12-year-old twins. Journal of the American Academy of Child and Adolescent Psychiatry, 42, 1351–1359.
Bearden, C., Rosso, I., Hollister, J., Sanchez, L., Hadley, T., & Cannon, T. (2000). A prospective cohort study of childhood behavioral deviance and language abnormalities as predictors of adult schizophrenia. Schizophrenia Bulletin, 26, 395–410.
Bentall, R., & Slade, P. (1985). Reality testing and auditory hallucinations: a signal detection analysis. British Journal of Clinical Psychology, 24, 159–169.
Bentall, R., Baker, G., & Havers, S. (1991a). Reality monitoring and psychotic hallucinations. British Journal of Clinical Psychology, 30, 213–222.
Bentall, R., Kaney, S., & Dewey, M. (1991b). Paranoia and social reasoning: an attribution theory analysis. British Journal of Clinical Psychology, 30, 13–23.
Blackwood, N., Howard, R., Bentall, R., & Murray, R. (2001). Cognitive neuropsychiatric models of persecutory delusions. American Journal of Psychiatry, 158, 527–539.
Bleuler, E. (1961). Dementia praecox or the group of schizophrenias. English translation. New-York: International Universities Press.
Cannon, M., Jones, P., Huttunen, M., Tanskanen, A., Rabe-Hesketh, S., & Murray, R. (1999). School performance in Finnish children and later development of schizophrenia: a population-based longitudinal study. Archives of General Psychiatry, 56, 457–463.
Caplan, R., Guthrie, D., Tang, T., Komo, S., & Asarnow, R. F. (2000). Thought disorder in childhood schizophrenia: replication and update of concept. Journal of American Academy of Child and Adolescent Psychiatry, 39, 771–778.
Chapman, L. J., Chapman, J. P., Kwapil, T. R., Eckblad, M., & Zinser, M. C. (1994). Putatively psychosis-prone subjects 10 years later. Journal of Abnormal Psychology, 103, 171–183.
Cohen, J. (1992). A power primer. Psychological Bulletin, 112, 155–159.
Cohen, J., Barch, D., Carter, C., & Servan-Schreiber, D. (1999). Context-processing deficits in schizophrenia: converging evidence from three theoretically motivated cognitive tasks. Journal of Abnormal Psychology, 108, 120–133.
Cronbach, L. J. (1987). Statistical tests for moderator variables: flaws in analyses recently proposed. Psychological Bulletin, 102, 414–417.
Crow, T. J., Done, D. J., & Sacker, A. (1995). Childhood precursors of psychosis as clues to its evolutionary origin. European Archives of Psychiatry and Clinical Neuroscience, 245, 61–69.
Cunningham, D., Miller, O., Lawrie, S., & Johnstone, E. (2005). Pathogenesis of schizophrenia: a psychopathological perspective. British Journal of Psychiatry, 186, 386–393.
Davidson, M., Reichenberg, A., Rabinowitz, J., Weiser, M., Kaplan, Z., & Mark, M. (1999). Behavioral and intellectual markers for schizophrenia in apparently healthy male adolescents. American Journal of Psychiatry, 156, 1328–1335.
DeLisi, L., Boccio, A., Rliordan, H., Hoff, A., Dorfman, A., McClelland, J., et al. (1991). Familial thyroid disease and delayed language development in first admission patients with schizophrenia. Psychiatry Research, 38, 39–50.
Done, D. J., Crow, T. J., Johnstone, E. C., & Sacker, A. (1994). Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11. British Medical Journal, 309, 699–703.
Duhig, A. M., Renk, K., Epstein, M. K., & Phares, V. (2000). Interparental agreement on internalizing, externalizing, and total behavior problems: a meta-analysis. Clinical Psychology: Science and Practice, 7, 435–453.
Dworkin, R., Lewis, J., Cornblatt, B., & Erlenmeyer-Kimling, L. (1994). Social competence deficits in adolescents at risk for schizophrenia. Journal of Nervous and Mental Disease, 182, 103–108.
Fagel, S. S. A. A., Swaab, H., De Sonneville, L. M., Van Rijn, S., Pieterse, J. K., Scheepers, F., et al. (2013). Development of schizotypal symptoms following psychiatric disorders in childhood or adolescence. European Child and Adolescent Psychiatry. In press.
Fish, B. (1987). Infant predictors of the longitudinal course of schizophrenic development. Schizophrenia Bulletin, 13, 395–409.
Fish, B., Marcus, J., Hans, S., Auerbach, J. G., & Perdue, S. (1992). Infants at risk for schizophrenia: Sequelae of a genetic neurointegrative defect. Archives of General Psychiatry, 49, 221–235.
Foerster, A., Lawis, S., Owen, M., & Murray, R. (1991). Pre-morbid adjustment and personality in psychosis. British Journal of Psychiatry, 158, 171–176.
Goldstein, J. M., & Link, B. G. (1988). Gender and the expression of schizophrenia. Journal of Psychiatry Research, 22, 141–155.
Gooding, D. C., Tallent, K. A., & Matts, C. W. (2005). Clinical status of at-risk individuals 5 years later: further validation of the psychometric high-risk strategy. Journal of Abnormal Psychology, 114, 170–175.
Goodman, S. (1987). Emory university project on children of disturbed parents. Schizophrenia Bulletin, 13, 411–423.
Johnston, M., & Holzman, P. (1979). Assessing schizophrenic thinking (pag 56-101). San Francisco: Jossey-Bass.
Johnstone, E., Ebmeier, K., Miller, P., Owens, D., & Lawrie, S. (2005). Predicting schizophrenia: findings from the Edinburgh high-risk study. British Journal of Psychiatry, 186, 18–25.
Jones, P., Rodgers, B., Murray, R., & Marmot, M. (1994). Child development risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet, 344, 1398–1402.
Kendler, K. (1988). Familial aggregation of schizophrenia and schizophrenia spectrum disorders: evaluation of conflicting results. Archives of General Psychiatry, 45, 377–383.
Kerns, J. (2006). Schizotypy facets, cognitive control, and emotion. Journal of Abnormal Psychology, 115, 418–427.
Kerns, J., & Berenbaum, H. (2002). Cognitive impairments associated with formal thought disorder in people with schizophrenia. Journal of Abnormal Psychology, 111, 211–224.
Kraepelin, E. (1919). Dementia praecox and paraphrenia (R. Barclay, Trans.). Chicago: Chicago Medical Book. (Original work published 1916).
Kwapil, T. R. (1998). Social anhedonia as a predictor of the development of schizophrenia spectrum disorders. Journal of Abnormal Psychology, 107, 558–565.
Malmberg, A., Lewis, G., David, A., & Allebeck, P. (1998). Premorbid adjustment and personality in people with schizophrenia. British Journal of Psychiatry, 172, 308–313. discussion 314–315.
McGlashan, T. H., & Bardenstein, K. K. (1990). Gender differences in affective, schizoaffective, and schizophrenic disorders. Schizophrenia Bulletin, 16, 319–329.
Mednick, S., & Schulsinger, F. (1968). Some premorbid characteristics related to breakdown in children with schizophrenic mothers. Journal of Psychiatry Research, 6, 267–291.
Meehl, P. E. (1962). Schizotaxia, schizotypy, schizophrenia. American Psychology, 17, 827–838.
Meehl, P. E. (1990). Toward an integrated theory of schizotaxia, schizotypy, and schizophrenia. Journal of Personality Disorders, 4, 1–99.
Miller, P. M., Byrne, M., Hodges, A., Lawrie, S. M., & Johnstone, E. C. (2002). Childhood behaviour, psychotic symptoms and psychosis onset in young people at high risk of schizophrenia: early findings from the Edinburgh high risk study. Psychological Medicine, 32, 173–179.
Moritz, S., Andresen, B., Naber, D., Krausz, M., & Probsthein, E. (1999). Neuropsychological correlates of schizotypal disorganization. Cognitive Neuropsychiatry, 4, 343–349.
Muratori, F., Salvadori, F., D’Arcangelo, G., Viglione, V., & Picchi, L. (2005). Childhood psychopathological antecedents in early onset schizophrenia. European Psychiatry, 20, 309–314.
Nagler, S., & Glueck, Z. (1985). The clinical interview. Schizophrenia Bulletin, 11, 38–47.
Olin, S., Raine, A., Cannon, T., Pamas, J., Schulsinger, F., & Mednick, S. (1997). Childhood behavior precursors of schizotypal personality disorder. Schizophrenia Bulletin, 23, 93–103.
Polderman, T. J., Posthuma, D., De Sonneville, L. M. J., Verhulst, F. C., & Boomsma, D. I. (2006). Genetic analyses of teacher ratings of problem behavior in 5-year-old twins. Twin Research and Human Genetics, 9, 122–130.
Raine, A. (1991). The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophrenia Bulletin, 17, 555–564.
Raine, A. (2006). Schizotypal personality: neurodevelopmental and psychosocial trajectories. Annual Reviews of Clinical Psychology, 2, 291–326.
Raine, A., Reynolds, C., Lencz, T., Scerbo, A., Triphon, N., & Kim, D. (1994). Cognitive-perceptual, interpersonal, and disorganized features of schizotypal personality. Schizophrenia Bulletin, 20, 191–201.
Reynolds, C., Raine, A., Mellingen, K., Venables, P., & Mednick, S. (2000). Three-factor model of schizotypal personality: Invariance across culture, gender, religious affiliation, family adversity, and psychopathology. Schizophrenia Bulletin, 26, 603–618.
Rossi, A., Pollice, R., Daneluzzo, E., Marinangeli, M., & Stratta, P. (2000). Behavioral neurodevelopment abnormalities and schizophrenic disorder: A retrospective evaluation with the Childhood Behavior Checklist (CBCL). Schizophrenia Research, 44, 121–128.
Rosso, I., Bearden, C., Hollister, J., Gasperoni, T., Sanchez, L., Hadley, T., et al. (2000). Childhood neuromotor dysfunction in schizophrenia patients and their unaffected siblings: A prospective cohort study. Schizophrenia Bulletin, 26, 367–378.
Salem, J. E., & Kring, A. M. (1998). The role of gender differences in the reduction of etiologic heterogeneity in schizophrenia. Clinical Psychology Review, 18, 795–819.
Salokangas, R. K. R. (1983). Prognostic implications of the sex of schizophrenic patients. British Journal of Psychiatry, 142, 145–151.
Schuklenk, U. (2001). Helsinki declaration revisions. Issues Medical Ethics, 9, 29.
Scott, J., Martin, G., Welham, J., Bor, W., Najman, J., O’Callaghan, M., et al. (2009). Psychopathology during childhood and adolescence predicts delusional-like experiences in adults: a 21-year birth cohort study. American Journal of Psychiatry, 166, 567–574.
Smith, S. R. (2007). Making sense of multiple informants in child and adolescent psychopathology: a guide for clinicians. Journal of Psychoeducational Assessment, 25, 139–149.
Tarbox, S. I., & Pogue-Geile, M. F. (2008). Development of social functioning in preschizophrenia children and adolescents: a systematic review. Psychological Bulletin, 134, 561–583.
Tompson, M., Asarnow, J., Goldstein, M., & Milkowitz, D. J. (1990). Thought disorder and communication problems in schizophrenia and depressed children and their parents. Journal of Child Psychology and Psychiatry, 19, 159–168.
Tsuang, M., Stone, W., Tarbox, S., & Faraone, S. (2002). An integration of schizophrenia with schizotypy: identification of schizotaxia and implications for research on treatment and prevention. Schizophrenia Research, 54, 169–175.
Van der Ende, J., & Verhulst, F. C. (2005). Informant, gender and age differences in ratings of adolescent problem behavior. European Child and Adolescent Psychiatry, 14, 117–126.
Van der Valk, J. C., Van den Oord, E. J. C. G., Verhulst, F. C., & Boomsma, D. I. (2001). Using parental ratings to study the etiology of 3-year-old twins’ problem behaviors: Different views or rater bias? Journal of Child Psychology and Psychiatry, 42, 921–931.
Velthorst, E., Nieman, D., Becker, H., Van de Fliert, R., Dingemans, P., Klaassen, R., et al. (2009). Baseline differences in clinical symptomatology between ultra-high risk subjects with and without a transition to psychosis. Schizophrenia Research, 109, 60–65.
Ventura, J., Thames, A., Wood, R., Guzik, L., & Hellemann, G. (2010). Disorganization and reality distortion in schizophrenia: a meta-analysis of the relationship between positive symptoms and neurocognitive deficits. Schizophrenia Research, 121, 1–14.
Verhulst, F. C., Van der Ende, J., & Koot, H. M. (1997). Manual for the Teacher’s Report Form (Dutch translation). Department of Child and Adolescent Psychiatry, Rotterdam, the Netherlands.
Vollema, M., & Hoijtink, H. (2000). The multidimensionality of self-report schizotypy in a psychiatric population: an analysis using multidimensional rasch models. Schizophrenia Bulletin, 26, 565–575.
Vollema, M., Sitskoorn, M., Appels, M., & Kahn, R. (2002). Does the schizotypal personality questionnaire reflect the biological-genetic vulnerability to schizophrenia? Schizophrenia Research, 54, 39–45.
Walker, E., Lewis, N., Loewy, R., & Palyo, S. (1999). Motor dysfunction and risk for schizophrenia. Developmental Psychopathology, 11, 509–523.
Watt, N., & Lubensky, A. (1976). Childhood roots of schizophrenia. Journal of Consulting and Clinical Psychology, 44, 363–375.
Wechsler, D. (1949). Wechsler Intelligence Scale for Children (WISC). San Antonio, TX: The Psychological Corporation.
Wechsler, D. (1955). Manual for the Wechsler Adult Intelligence Scale (WAIS). New York: The Psychological Corporation.
Wechsler, D. (1967). Wechsler Preschool and Primary Scale of Intelligence (WPPSI). New York: The Psychological Corporation.
Wechsler, D. (1974). Manual for the Wechsler Intelligence Scale for Children—Revised (WISC-R). New York: The Psychological Corporation.
Wechsler, D. (1981). Manual for the Wechsler Adult Intelligence Scale-Revised (WAIS-R). New York: The Psychological Corporation.
Wechsler, D. (1991). Manual for the Wechsler Intelligence Scale for Children, Third Edition (WISC-III). San Antonio, TX: Psychological Corporation.
Weintraub, S., Prinz, R., & Neale, J. (1978). Peer evaluations of the competence of children vulnerable to psychopathology. Journal of Abnormal Child Psychology, 6, 461–473.
Welham, J., Scott, J., Williams, G., Najman, J., Bor, W., O’Callaghan, M., et al. (2009). Emotional and behavioural antecedents of young adults who screen positive for non-affective psychosis: A 21- year birth cohort study. Psychological Medicine, 39, 625–634.
Yung, A. R., Phillips, L. J., Yuen, H. P., & McGorry, P. D. (2004). Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features. Schizophrenia Research, 67, 131–142.
Zigler, E., Levine, J., & Zigler, B. (1977). Pre-morbid social competence and paranoid-non paranoid status in female schizophrenic patients. Journal of Nervous and Mental Disease, 164, 333–339.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Fagel, S., de Sonneville, L., van Engeland, H. et al. School-Associated Problem Behavior in Childhood and Adolescence and Development of Adult Schizotypal Symptoms: A Follow-Up of a Clinical Cohort. J Abnorm Child Psychol 42, 813–823 (2014). https://doi.org/10.1007/s10802-013-9829-6
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10802-013-9829-6