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Clinical features associated with the atrophy of fellow eyes in patients with unilateral type 3 macular neovascularization

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Abstract

Purpose

We sought to investigate the clinical features of eyes with unilateral type 3 macular neovascularization (MNV) according to the degenerative features of fellow eyes.

Methods

We retrospectively reviewed 55 patients with unilateral type 3 MNV and identified degenerative features including geographic atrophy (GA) in fellow eyes using multimodal imaging. Then, the clinical features of eyes with type 3 MNV at baseline and during follow-up with anti-vascular endothelial growth factor treatment and an as-needed regimen were compared according to the degenerative features of fellow eyes.

Results

Eighteen patients (32.7%) had GA in fellow eyes; initial disease manifestations of type 3 MNV eyes including stage, best-corrected visual acuity, and choroidal thickness (CT) did not vary between groups (all P > 0.05). During follow-up, a rate of complete fluid resolution after three monthly loading injections was not associated with GA in fellow eyes (P = 0.703), while a lower rate of early recurrence within 3 months after loading treatment was associated with thinner CT in type 3 MNV eyes and GA over one disc area in fellow eyes (P = 0.025 and P = 0.021).

Conclusion

Degenerative features of fellow eyes in patients with unilateral type 3 MNV may be associated with the clinical characteristics of affected eyes.

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Availability of data and materials

Data are available with the corresponding author on request.

References

  1. Ambati J, Ambati BK, Yoo SH, Ianchulev S, Adamis AP (2003) Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol 48:257–293. https://doi.org/10.1016/s0039-6257(03)00030-4

    Article  PubMed  Google Scholar 

  2. Freund KB, Ho IV, Barbazetto IA, Koizumi H, Laud K, Ferrara D, Matsumoto Y, Sorenson JA, Yannuzzi L (2008) Type 3 neovascularization: the expanded spectrum of retinal angiomatous proliferation. Retina 28:201–211. https://doi.org/10.1097/IAE.0b013e3181669504

    Article  PubMed  Google Scholar 

  3. Sawa M, Ueno C, Gomi F, Nishida K (2014) Incidence and characteristics of neovascularization in fellow eyes of Japanese patients with unilateral retinal angiomatous proliferation. Retina 34:761–767. https://doi.org/10.1097/01.iae.0000434566.57189.37

    Article  PubMed  Google Scholar 

  4. Spaide RF (2019) New proposal for the pathophysiology of type 3 neovascularization as based on multimodal imaging findings. Retina 39:1451–1464. https://doi.org/10.1097/iae.0000000000002412

    Article  CAS  PubMed  Google Scholar 

  5. Tsai ASH, Cheung N, Gan ATL, Jaffe GJ, Sivaprasad S, Wong TY, Cheung CMG (2017) Retinal angiomatous proliferation. Surv Ophthalmol 62:462–492. https://doi.org/10.1016/j.survophthal.2017.01.008

    Article  PubMed  Google Scholar 

  6. Kim JH, Kim JR, Kang SW, Kim SJ, Ha HS (2013) Thinner choroid and greater drusen extent in retinal angiomatous proliferation than in typical exudative age-related macular degeneration. Am J Ophthalmol 155:743–749. https://doi.org/10.1016/j.ajo.2012.11.001

    Article  PubMed  Google Scholar 

  7. McBain VA, Kumari R, Townend J, Lois N (2011) Geographic atrophy in retinal angiomatous proliferation. Retina 31:1043–1052. https://doi.org/10.1097/IAE.0b013e3181fe54c7

    Article  PubMed  Google Scholar 

  8. Baek J, Lee JH, Kim JY, Kim NH, Lee WK (2016) Geographic atrophy and activity of neovascularization in retinal angiomatous proliferation. Invest Ophthalmol Vis Sci 57:1500–1505. https://doi.org/10.1167/iovs.15-18837

    Article  CAS  PubMed  Google Scholar 

  9. Lindner M, Böker A, Mauschitz MM, Göbel AP, Fimmers R, Brinkmann CK, Schmitz-Valckenberg S, Schmid M, Holz FG, Fleckenstein M (2015) Directional kinetics of geographic atrophy progression in age-related macular degeneration with foveal sparing. Ophthalmology 122:1356–1365. https://doi.org/10.1016/j.ophtha.2015.03.027

    Article  PubMed  Google Scholar 

  10. Schmitz-Valckenberg S, Sahel JA, Danis R, Fleckenstein M, Jaffe GJ, Wolf S, Pruente C, Holz FG (2016) Natural history of geographic atrophy progression secondary to age-related macular degeneration (geographic atrophy progression study). Ophthalmology 123:361–368. https://doi.org/10.1016/j.ophtha.2015.09.036

    Article  PubMed  Google Scholar 

  11. Guymer RH, Rosenfeld PJ, Curcio CA et al (2020) Incomplete retinal pigment epithelial and outer retinal atrophy in age-related macular degeneration: classification of atrophy meeting report 4. Ophthalmology 127:394–409. https://doi.org/10.1016/j.ophtha.2019.09.035

    Article  PubMed  Google Scholar 

  12. Su D, Lin S, Phasukkijwatana N, Chen X, Tan A, Freund KB, Sarraf D (2016) An updated staging system of type 3 neovascularization using spectral domain optical coherence tomography. Retina 36(Suppl 1):S40–S49. https://doi.org/10.1097/IAE.0000000000001268

    Article  PubMed  Google Scholar 

  13. Sadda SR, Guymer R, Holz FG et al (2018) Consensus definition for atrophy associated with age-related macular degeneration on OCT: classification of atrophy report 3. Ophthalmology 125:537–548. https://doi.org/10.1016/j.ophtha.2017.09.028

    Article  PubMed  Google Scholar 

  14. Nam KT, Chung HW, Jang S, Hwang SY, Kim SW, Oh J, Yun C (2021) Ganglion cell-inner plexiform layer thickness in eyes with nonexudative age-related macular degeneration of different drusen subtypes. Retina 41:1686–1696. https://doi.org/10.1097/iae.0000000000003100

    Article  CAS  PubMed  Google Scholar 

  15. Spaide RF, Ooto S, Curcio CA (2018) Subretinal drusenoid deposits AKA pseudodrusen. Surv Ophthalmol 63:782–815. https://doi.org/10.1016/j.survophthal.2018.05.005

    Article  PubMed  Google Scholar 

  16. Kwak JH, Park WK, Kim RY, Kim M, Park YG, Park YH (2021) Unaffected fellow eye neovascularization in patients with type 3 neovascularization: incidence and risk factors. PLoS ONE 16:e0254186. https://doi.org/10.1371/journal.pone.0254186

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Léveillard T, Philp NJ, Sennlaub F (2019) Is retinal metabolic dysfunction at the center of the pathogenesis of age-related macular degeneration? Int J Mol Sci. https://doi.org/10.3390/ijms20030762

    Article  PubMed  PubMed Central  Google Scholar 

  18. Kim JH, Chang YS, Kim JW, Kim CG, Lee DW, Cho SY (2018) Difference in treatment outcomes according to optical coherence tomography-based stages in type 3 neovascularization (Retinal Angiomatous Proliferation). Retina 38:2356–2362. https://doi.org/10.1097/IAE.0000000000001876

    Article  PubMed  Google Scholar 

  19. Lanzetta P, Loewenstein A, Vision Academy Steering C (2017) Fundamental principles of an anti-VEGF treatment regimen: optimal application of intravitreal anti-vascular endothelial growth factor therapy of macular diseases. Graefes Arch Clin Exp Ophthalmol 255:1259–1273. https://doi.org/10.1007/s00417-017-3647-4

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Haj Najeeb B, Deak GG, Mylonas G, Sacu S, Gerendas BS, Schmidt-Erfurth U (2022) The rap study, report 5: rediscovering macular neovascularization type 3: multimodal imaging of fellow eyes over 24 months. Retina 42:485–493. https://doi.org/10.1097/IAE.0000000000003330

    Article  CAS  PubMed  Google Scholar 

  21. Kim YK, Park SJ, Woo SJ, Park KH (2016) Choroidal thickness change after intravitreal anti-vascular endothelial growth factor treatment in retinal angiomatous proliferation and its recurrence. Retina 36:1516–1526. https://doi.org/10.1097/iae.0000000000000952

    Article  CAS  PubMed  Google Scholar 

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Funding

This work was supported by a grant from Korea University (K2212011).

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Authors and Affiliations

  1. Department of Ophthalmology, Korea University College of Medicine, 123, Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi-do, Seoul, Korea

    Eun Gyu Yoon & Cheolmin Yun

  2. Department of Ophthalmology, Jeju University College of Medicine, Jeju, Korea

    Ki Tae Nam

  3. Department of Ophthalmology, Korea University College of Medicine, 148 Gurodong-ro, Guro-gu, Seoul, Korea

    Mihyun Choi

Authors
  1. Mihyun Choi
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  2. Eun Gyu Yoon
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  4. Cheolmin Yun
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Contributions

C.Y. conceived and designed this study. M.C., E.G.Y and K.T.N. contributed to the acquisition and interpretation of data. C.Y. and M.C analyzed the data and drafted the article. C.Y. prepared Fig. 1. All authors contributed to interpretation of results and were involved in critical revision and approval of the final version.

Corresponding author

Correspondence to Cheolmin Yun.

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Competing interests

The authors declare no competing interests.

Conflict of interest

None of the authors has any financial/conflicting interests to disclose.

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The need for informed consent was waived by Institutional Review Board of Korea University Medical Center.

Ethical approval

All procedures performed in studies were in accordance with the ethical standards of the Institutional Review Board of Korea University Medical Center and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Choi, M., Yoon, E.G., Nam, K.T. et al. Clinical features associated with the atrophy of fellow eyes in patients with unilateral type 3 macular neovascularization. Int Ophthalmol 43, 973–980 (2023). https://doi.org/10.1007/s10792-022-02499-9

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  • DOI: https://doi.org/10.1007/s10792-022-02499-9

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