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Intraocular pressure trend following myopic photorefractive keratectomy

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Abstract

Purpose

To evaluate the intraocular pressure (IOP) trend and risk factors for IOP rise after myopic photorefractive keratectomy (PRK).

Patients and methods

One eye of each patient undergone PRK for myopia was randomly assigned to this study. All eyes underwent tonometry by CorVis Scheimpflug Technology (CST) tonometer (Oculus Optikgeräte GmbH, Wetzlar, Germany) 1 week, 2 weeks, 1 month, 2 months, 3 months and 4 months after surgery. The eyes with IOP rise more than 5 mmHg and the risk factors were evaluated by Kaplan–Meier graph and multiple Cox regression analysis.

Results

A total of 348 eyes of 348 patients were enrolled in this study. Forty-three eyes (12.35%) experienced a steroid-induced IOP rise of more than 5 mmHg. Eyes with IOP rise had higher baseline IOP (Median 19 mmHg (IQR 18–22) versus Median 15 mmHg (IQR 14–16); p < 0.001). Baseline central corneal thickness (CCT) was higher in eyes without IOP rise (Median 520 µm (IQR 509–541) versus Median 535 µm (IQR 518–547); p = 0.009). In multivariate Cox regression analysis, higher baseline IOP was a risk factor for IOP rise (Hazard Ratio (HR) 1.59 (95% CI 1.43–1.77); p < 0.001) while higher baseline CCT was protective (HR 0.97 (95% CI 0.95–0.98); p < 0.001).

Conclusion

Eyes with higher baseline IOP and lower baseline CCT are at increased risk of IOP rise after PRK and should be monitored more frequently.

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Availability of data and material

The data that support the findings of this study are available from the corresponding author, [SMT], upon reasonable request.

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Funding

The authors received no financial support for the research, authorship, and/or publication of this article.

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Authors and Affiliations

  1. Glaucoma Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Ghasem Fakhraie, Zakieh Vahedian, Reza Zarei, Yadollah Eslami, Seyed Mehdi Tabatabaei, Abdollah Hadi, Sepideh Ghods & Ali Fakhraie

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  1. Ghasem Fakhraie
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  2. Zakieh Vahedian
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  3. Reza Zarei
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  4. Yadollah Eslami
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  5. Seyed Mehdi Tabatabaei
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  7. Sepideh Ghods
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Correspondence to Seyed Mehdi Tabatabaei.

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Conflict of interest

Ghasem Fakhraie declares that he has no conflict of interest. Zakieh Vahedian declares that she has no conflict of interest. Reza Zarei declares that he has no conflict of interest. Yadollah Eslami declares that he has no conflict of interest. Seyed Mehdi Tabatabaei declares that he has no conflict of interest. Abdollah Hadi declares that he has no conflict of interest. Sepideh Ghods declares that she has no conflict of interest. Ali Fakhraie declares that he has no conflict of interest.

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All procedures performed in this study which involve human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Fakhraie, G., Vahedian, Z., Zarei, R. et al. Intraocular pressure trend following myopic photorefractive keratectomy. Int Ophthalmol 42, 2313–2321 (2022). https://doi.org/10.1007/s10792-022-02228-2

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  • DOI: https://doi.org/10.1007/s10792-022-02228-2

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