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Patterns of cytomegalovirus retinitis at a tertiary referral center in Turkey

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Abstract

Purpose

To analyze predisposing conditions in Turkish patients with CMV retinitis and to compare HIV-positive and HIV-negative patients.

Methods

We reviewed medical charts and ocular images of 41 patients with CMV retinitis diagnosed between 1996 and 2019.

Results

Eleven patients (27%) had HIV infection and 30 were immunocompromised from diverse causes. Initial visual acuity, type, zone, and extent of CMV retinitis, and response to anti-CMV treatment were not significantly different between the two groups. Vitreous haze and panretinal occlusive vasculopathy were the presenting features only in non-HIV patients, seen in 34% and 16% of eyes, respectively. Although not statistically significant, recurrent CMV retinitis was more common in non-HIV patients (17.4% vs. 4.3%/eye-year) and immune recovery uveitis was more common in HIV patients (43% vs. 26%/eye-year). Visual outcomes were similar. Final visual acuity of 1 logMAR or worse was significantly associated with the recurrence of CMV retinitis (odds ratio 9.67; p = 0.01) and also with the occurrence of immune recovery uveitis (odds ratio 4.31; p = 0.058).

Conclusions

Diverse immunocompromising conditions are more commonly associated with CMV retinitis than HIV infection in Turkish patients. Intraocular inflammation was more commonly associated with active retinitis in non-HIV patients and immune recovery uveitis was more common in HIV patients.

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, Istanbul University, Istanbul Tip Fakultesi Goz Hastaliklari A.D. Capa, 34093, Istanbul, Turkey

    Muhammed Talha Sadik, Nihan Aksu Ceylan, Zafer Cebeci, Nur Kir, Merih Oray & Ilknur Tugal-Tutkun

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  1. Muhammed Talha Sadik
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  2. Nihan Aksu Ceylan
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  3. Zafer Cebeci
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  4. Nur Kir
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Correspondence to Ilknur Tugal-Tutkun.

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Sadik, M.T., Aksu Ceylan, N., Cebeci, Z. et al. Patterns of cytomegalovirus retinitis at a tertiary referral center in Turkey. Int Ophthalmol 41, 2981–2992 (2021). https://doi.org/10.1007/s10792-021-01857-3

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  • DOI: https://doi.org/10.1007/s10792-021-01857-3

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