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The effects of tropicamide and cyclopentolate hydrochloride on laser flare meter measurements in uveitis patients: a comparative study

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Abstract

Purpose

To investigate the effects of 1% cyclopentolate hydrochloride and 1% tropicamide eye drops on aqueous flare measurements by using the laser flare meter.

Methods

One hundred forty eight eyes of 83 patients with inactive uveitis were enrolled. The patients were randomly assigned to receive either 1% tropicamide (Group 1) or 1% cyclopentolate hydrochloride (Group 2) as the mydriatic agent. Best corrected visual acuity (BCVA), intraocular pressure (IOP), aqueous flare reaction levels measured by laser flare meter device (FM 600, Kowa, Kowa Company Ltd, Nagoya, Japan) before and post dilatation agents were evaluated.

Results

Group 1 consisted of 75 eyes and Group 2 consisted of 77 eyes. The mean age of Group 1 patients was 34.85 ± 12.60 (range, 12–64) years; the mean age of Group 2 was 36.92 ± 13.30 (range, 12–70) years (p > 0.05). The mean BCVAs of two groups were 0.16 ± 0.43 (range, 0.00–3.10) logMAR and 0.17 ± 0.42 (range, 0.00–3.10) logMAR, respectively. There were no statistically significant differences between Groups 1 and 2 regarding gender or clinical characteristics (p > 0.05). No significant differences were detected in pre- or post-dilatation values between two groups (p = 0.470, p = 0.998).

Conclusions

As a result, anterior chamber flare values in uveitis patients do not differ significantly between 1% tropicamide and 1% cyclopentolate hydrochloride, and both agents can be safely used for dilatation during examination of patients with uveitis.

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Acknowledgement

This study was produced from Ege University scientific research project number 2013-TIP-106.

Funding

No financial support was received for this submission.

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Authors and Affiliations

  1. Manisa Merkezefendi State Hospital, Manisa, Turkey

    Medine Yilmaz

  2. Department of Ophthalmology, Ege University School of Medicine, 35100, Bornova, Izmir, Turkey

    Suzan Guven Yilmaz, Melis Palamar, Halil Ates & Ayse Yagci

Authors
  1. Medine Yilmaz
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  2. Suzan Guven Yilmaz
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  3. Melis Palamar
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  4. Halil Ates
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  5. Ayse Yagci
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Correspondence to Suzan Guven Yilmaz.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent Informed consent was obtained from all individual participants included in the study.

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Yilmaz, M., Guven Yilmaz, S., Palamar, M. et al. The effects of tropicamide and cyclopentolate hydrochloride on laser flare meter measurements in uveitis patients: a comparative study. Int Ophthalmol 41, 853–857 (2021). https://doi.org/10.1007/s10792-020-01639-3

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  • DOI: https://doi.org/10.1007/s10792-020-01639-3

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