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Comparison of the efficacy of nepafenac 0.1% in quiescent Behçet’s uveitis and non-uveitic healthy patients after phacoemulsification surgery

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Abstract

Purpose

To compare the efficacy of nepafenac on anterior chamber flare and intraocular pressure(IOP) in healthy (group 1) and uveitic eyes (group 2) undergoing cataract surgery.

Methods

A retrospective, consecutive case series study.

Results

Among 54 the patients, 14 had a history of uveitis. The groups were similar in age and gender. There were significant changes in flare values in both groups. When the temporal changes of flare values were compared, there was no difference between the two groups. There were no significant changes in IOP values in both group. When the temporal changes of IOP values were compared, there was no difference between the groups.

Conclusions

Nepafenac 0.1% has been shown to be effective in suppressing inflammation after cataract surgery in uveitic eyes as well as in healthy eyes. In addition, it has been observed that it does not increase intraocular pressure in both healthy and uveitic eyes and it is safe to use with this regard.

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References

  1. Congdon N, Vingerling JR, Klein BE, West S, Friedman DS, Kempen J, O'Colmain B, Wu SY, Taylor HR, Eye Diseases Prevalence Research G (2004) Prevalence of cataract and pseudophakia/aphakia among adults in the United States. Arch Ophthalmol 122(4):487–494. https://doi.org/10.1001/archopht.122.4.487

    Article  Google Scholar 

  2. Mangione CM, Phillips RS, Lawrence MG, Seddon JM, Orav EJ, Goldman L (1994) Improved visual function and attenuation of declines in health-related quality of life after cataract extraction. Arch Ophthalmol 112(11):1419–1425. https://doi.org/10.1001/archopht.1994.01090230033017

    Article  CAS  PubMed  Google Scholar 

  3. McGwin G Jr, Scilley K, Brown J, Owsley C (2003) Impact of cataract surgery on self-reported visual difficulties: comparison with a no-surgery reference group. J Cataract Refract Surg 29(5):941–948. https://doi.org/10.1016/s0886-3350(02)01846-1

    Article  PubMed  Google Scholar 

  4. Sandoval HP, Fernandez de Castro LE, Vroman DT, Solomon KD (2007) A review of the use of ketorolac tromethamine 0.4% in the treatment of post-surgical inflammation following cataract and refractive surgery. Clin Ophthalmol 1(4):367–371

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Kim SJ, Flach AJ, Jampol LM (2010) Nonsteroidal anti-inflammatory drugs in ophthalmology. Surv Ophthalmol 55(2):108–133. https://doi.org/10.1016/j.survophthal.2009.07.005

    Article  PubMed  Google Scholar 

  6. O'Brien TP (2005) Emerging guidelines for use of NSAID therapy to optimize cataract surgery patient care. Curr Med Res Opin 21(7):1131–1137. https://doi.org/10.1185/030079905X50651

    Article  CAS  PubMed  Google Scholar 

  7. Wolf EJ, Braunstein A, Shih C, Braunstein RE (2007) Incidence of visually significant pseudophakic macular edema after uneventful phacoemulsification in patients treated with nepafenac. J Cataract Refract Surg 33(9):1546–1549. https://doi.org/10.1016/j.jcrs.2007.05.018

    Article  PubMed  Google Scholar 

  8. Tugal-Tutkun I, Herbort CP (2010) Laser flare photometry: a noninvasive, objective, and quantitative method to measure intraocular inflammation. Int Ophthalmol 30(5):453–464. https://doi.org/10.1007/s10792-009-9310-2

    Article  PubMed  Google Scholar 

  9. Isik MU, Yalcindag N (2020) Comparison of spectral domain optical coherence tomography (SD OCT) Findings with Laser Flare Photometry (LFP) Measurements in Behcet's Uveitis. Ocul Immunol Inflamm 28(2):194–199. https://doi.org/10.1080/09273948.2018.1552976

    Article  PubMed  Google Scholar 

  10. Ahuja M, Dhake AS, Sharma SK, Majumdar DK (2008) Topical ocular delivery of NSAIDs. AAPS J 10(2):229–241. https://doi.org/10.1208/s12248-008-9024-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Colin J (2007) The role of NSAIDs in the management of postoperative ophthalmic inflammation. Drugs 67(9):1291–1308. https://doi.org/10.2165/00003495-200767090-00004

    Article  CAS  PubMed  Google Scholar 

  12. Schalnus R (2003) Topical nonsteroidal anti-inflammatory therapy in ophthalmology. Ophthalmologica 217(2):89–98. https://doi.org/10.1159/000068563

    Article  CAS  PubMed  Google Scholar 

  13. Abel R Jr, Abel AD (1997) Perioperative antibiotic, steroid, and nonsteroidal anti-inflammatory agents in cataract intraocular lens surgery. Curr Opin Ophthalmol 8(1):29–32

    Article  PubMed  Google Scholar 

  14. Tzelikis PF, Vieira M, Hida WT, Motta AF, Nakano CT, Nakano EM, Alves MR (2015) Comparison of ketorolac 0.4% and nepafenac 0.1% for the prevention of cystoid macular oedema after phacoemulsification: prospective placebo-controlled randomised study. Br J Ophthalmol 99(5):654–658. https://doi.org/10.1136/bjophthalmol-2014-305803

    Article  PubMed  Google Scholar 

  15. Lane SS (2006) Nepafenac: a unique nonsteroidal prodrug. Int Ophthalmol Clin 46(4):13–20. https://doi.org/10.1097/01.iio.0000212129.53019.49

    Article  PubMed  Google Scholar 

  16. Wilson DJ, Schutte SM, Abel SR (2015) Comparing the efficacy of ophthalmic NSAIDs in common indications: a literature review to support cost-effective prescribing. Ann Pharmacother 49(6):727–734. https://doi.org/10.1177/1060028015574593

    Article  CAS  PubMed  Google Scholar 

  17. Lane SS, Modi SS, Lehmann RP, Holland EJ (2007) Nepafenac ophthalmic suspension 0.1% for the prevention and treatment of ocular inflammation associated with cataract surgery. J Cataract Refract Surg 33(1):53–58. https://doi.org/10.1016/j.jcrs.2006.08.043

    Article  Google Scholar 

  18. Nardi M, Lobo C, Bereczki A, Cano J, Zagato E, Potts S, Sullins G, Notivol R (2007) Analgesic and anti-inflammatory effectiveness of nepafenac 0.1% for cataract surgery. Clin Ophthalmol 1(4):527–533

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Zhao X, Xia S, Wang E, Chen Y (2017) Comparison of the efficacy and patients' tolerability of Nepafenac and Ketorolac in the treatment of ocular inflammation following cataract surgery: A meta-analysis of randomized controlled trials. PLoS ONE 12(3):e0173254. https://doi.org/10.1371/journal.pone.0173254

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Cagini C, Pellegrino A, Cerquaglia A, Iaccheri B, Lupidi M, Fiore T (2020) Comparison of the effect of diclofenac 0.1% and nepafenac 0.1% on aqueous flare in patients undergoing cataract surgery: a prospective randomized study. Curr Eye Res. https://doi.org/10.1080/02713683.2020.1725061

    Article  PubMed  Google Scholar 

  21. Duan P, Liu Y, Li J (2017) The comparative efficacy and safety of topical non-steroidal anti-inflammatory drugs for the treatment of anterior chamber inflammation after cataract surgery: a systematic review and network meta-analysis. Graefes Arch Clin Exp Ophthalmol 255(4):639–649. https://doi.org/10.1007/s00417-017-3599-8

    Article  CAS  Google Scholar 

  22. Kessel L, Tendal B, Jorgensen KJ, Erngaard D, Flesner P, Andresen JL, Hjortdal J (2014) Post-cataract prevention of inflammation and macular edema by steroid and nonsteroidal anti-inflammatory eye drops: a systematic review. Ophthalmology 121(10):1915–1924. https://doi.org/10.1016/j.ophtha.2014.04.035

    Article  PubMed  Google Scholar 

  23. Ray S, D'Amico DJ (2002) Pseudophakic cystoid macular edema. Semin Ophthalmol 17(3–4):167–180

    Article  PubMed  Google Scholar 

  24. Dave P, Shah K, Ramchandani B, Jain R (2014) Effect of nepafenac eye drops on intraocular pressure: a randomized prospective study. Am J Ophthalmol 157(3):735–738. https://doi.org/10.1016/j.ajo.2013.12.015

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

There are no sources of support including sponsorship (e.g., university, charity, commercial organization) and sources of material (e.g., novel drugs) not available commercially.

Funding

The authors did not receive any financial support from any public or private sources. The authors have no financial or proprietary interest in a product, method, or material described herein.

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Authors and Affiliations

  1. Ophthalmology Department, Balıklıgöl State Hospital, Sanliurfa, Turkey

    Mehmed Uğur Işık

  2. Ophthalmology Department, Ankara University, Ankara, Turkey

    Nilüfer F. Yalçındağ

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  1. Mehmed Uğur Işık
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  2. Nilüfer F. Yalçındağ
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Correspondence to Mehmed Uğur Işık.

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Işık, M.U., Yalçındağ, N.F. Comparison of the efficacy of nepafenac 0.1% in quiescent Behçet’s uveitis and non-uveitic healthy patients after phacoemulsification surgery. Int Ophthalmol 40, 2345–2351 (2020). https://doi.org/10.1007/s10792-020-01419-z

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  • DOI: https://doi.org/10.1007/s10792-020-01419-z

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