Abstract
Purpose
To investigate the effect of the diabetes on cataract formation by Pentacam Scheimpflug topography system.
Materials and methods
Thirty diabetic patients and thirty-five healthy control subjects were included in the study. Exclusion criteria were smoking, high refractive error, any systemic disease or drug usage associated with cataract formation and to have diabetic retinopathy. The duration of diabetes and HbA1c level were recorded. A comprehensive ophthalmologic examination was performed in all cases. Pentacam (Oculus, Wetzlar, Germany) three-dimensional lens densitometer module was used to measure density of anterior, nuclear and posterior lens regions.
Results
Mean age of group 1 and group 2 was 37.80 ± 5.51 years and 36.51 ± 3.77 years, respectively. There were not any difference between groups in the means of age and sex (P = .271; P = .700). The mean duration of diabetes in group 1 was 4.23 ± 3.71 years (6 months–10 year). The mean HbA1c level was 8.12 ± 2.07% (5.4–12.7%). Anterior, nuclear and posterior mean lens densitometry measurements were significantly higher in group 1 (diabetic group) than group 2 (control group) [(8.90 ± 0.59%; 8.05 ± 0.72% P = < .001), (7.52 ± 0.31%; 7.00 ± 0.59% P = < .001), (7.25 ± 0.31%; 6.90 ± 0.73% P = .006), respectively].
Conclusion
Diabetes may have cataractous effect in anterior, nuclear and posterior regions of the lens.
Similar content being viewed by others
References
Boyle JP, Thompson TJ, Gregg EW, Barker LE, Williamson DF (2010) Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence. Popul Health Metr 8:29. https://doi.org/10.1186/1478-7954-8-29
Vieira-Potter VJ, Karamichos D, Lee DJ (2016) Ocular Complications of Diabetes and Therapeutic Approaches. Biomed Res Int 2016:3801570. https://doi.org/10.1155/2016/3801570
Kiziltoprak H, Tekin K, Inanc M, Goker YS (2019) Cataract in diabetes mellitus. World J Diabetes 10(3):140–153. https://doi.org/10.4239/wjd.v10.i3.140
Pascolini D, Mariotti SP (2012) Global estimates of visual impairment: 2010. British J Ophthalmol 96(5):614–618. https://doi.org/10.1136/bjophthalmol-2011-300539
Li L, Wan XH, Zhao GH (2014) Meta-analysis of the risk of cataract in type 2 diabetes. BMC Ophthalmol 14:94. https://doi.org/10.1186/1471-2415-14-94
Richter GM, Torres M, Choudhury F, Azen SP, Varma R, Los Angeles Latino Eye Study G (2012) Risk factors for cortical, nuclear, posterior subcapsular, and mixed lens opacities: the Los Angeles Latino Eye Study. Ophthalmology 119(3):547–554. https://doi.org/10.1016/j.ophtha.2011.09.005
Leske MC, Chylack LT Jr, Wu SY (1991) The lens opacities case-control study. Risk factors for cataract. Arch Ophthalmol 109(2):244–251
Delcourt C, Cristol J-P, Tessier F, Leger CL, Michel F, Papoz L, POLA study group (2000) Risk factors for cortical, nuclear, and posterior subcapsular cataracts: the POLA study. Am J Ophthalmol 151:497–504
Kar T, Ayata A, Aksoy Y, Kaya A, Unal M (2014) The effect of chronic smoking on lens density in young adults. Eur J Ophthalmol 24(5):682–687. https://doi.org/10.5301/ejo.5000454
Kador PF, Wyman M, Oates PJ (2016) Aldose reductase, ocular diabetic complications and the development of topical Kinostat((R)). Prog Retinal Eye Res 54:1–29. https://doi.org/10.1016/j.preteyeres.2016.04.006
Kinoshita JH (1974) Mechanisms initiating cataract formation. Proctor Lect Investig Ophthalmol 13(10):713–724
Klein BE, Klein R, Moss SE (1995) Incidence of cataract surgery in the Wisconsin Epidemiologic Study of Diabetic Retinopathy. Am J Ophthalmol 119(3):295–300
Olofsson EM, Marklund SL, Behndig A (2009) Enhanced diabetes-induced cataract in copper-zinc superoxide dismutase-null mice. Invest Ophthalmol Vis Sci 50(6):2913–2918. https://doi.org/10.1167/iovs.09-3510
Olofsson EM, Marklund SL, Karlsson K, Brannstrom T, Behndig A (2005) In vitro glucose-induced cataract in copper-zinc superoxide dismutase null mice. Exp Eye Res 81(6):639–646. https://doi.org/10.1016/j.exer.2005.03.022
McCord JM, Fridovich I (1969) Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 244(22):6049–6055
Chiou SH, Chang CJ, Chou CK, Hsu WM, Liu JH, Chiang CH (1999) Increased nitric oxide levels in aqueous humor of diabetic patients with neovascular glaucoma. Diabetes Care 22(5):861–862. https://doi.org/10.2337/diacare.22.5.861a
Raman R, Pal SS, Adams JS, Rani PK, Vaitheeswaran K, Sharma T (2010) Prevalence and risk factors for cataract in diabetes: Sankara Nethralaya Diabetic Retinopathy Epidemiology and molecular genetics study, report No. 17. Investig Ophthalmol Vis Sci 51(12):6253–6261. https://doi.org/10.1167/iovs.10-5414
Hennis A, Wu SY, Nemesure B, Leske MC, Barbados Eye Studies G (2004) Risk factors for incident cortical and posterior subcapsular lens opacities in the Barbados Eye Studies. Arch Ophthalmol 122(4):525–530. https://doi.org/10.1001/archopht.122.4.525
Zhang X, Zhao J, Zhao T, Liu H (2015) Effects of intensive glycemic control in ocular complications in patients with type 2 diabetes: a meta-analysis of randomized clinical trials. Endocrine 49(1):78–89. https://doi.org/10.1007/s12020-014-0459-8
Chen SJ, Liu JH, Shih HC, Chou P, Tsai CY, Tung TH (2008) Prevalence and associated factors of lens opacities among Chinese type 2 diabetics in Kinmen. Taiwan Acta Diabetol 45(1):7–13. https://doi.org/10.1007/s00592-007-0012-9
Tung TH, Liu JH, Lee FL, Chen SJ, Tsai CY, Chou P (2005) Community-based study of cataracts among type 2 diabetics in Kinmen. Eur J Epidemiol 20(5):435–441
Tsai CY, Tung TH, Woung LC, Liu JH, Lee FL, Shih HC, Chen SJ, Chou P (2007) Population-based study of cataract surgery among patients with type 2 diabetes in Kinmen, Taiwan. Can J Ophthalmol J can d'ophtalmol 42(2):262–267. https://doi.org/10.3129/canjophthalmol.i07-013
Kirkwood BJ, Hendicott PL, Read SA, Pesudovs K (2009) Repeatability and validity of lens densitometry measured with Scheimpflug imaging. J Cataract Refract Surg 35(7):1210–1215. https://doi.org/10.1016/j.jcrs.2009.03.017
Pei X, Bao Y, Chen Y, Li X (2008) Correlation of lens density measured using the Pentacam Scheimpflug system with the Lens Opacities Classification System III grading score and visual acuity in age-related nuclear cataract. British J Ophthalmol 92(11):1471–1475. https://doi.org/10.1136/bjo.2007.136978
Grewal DS, Brar GS, Grewal SP (2009) Correlation of nuclear cataract lens density using Scheimpflug images with Lens Opacities Classification System III and visual function. Ophthalmology 116(8):1436–1443. https://doi.org/10.1016/j.ophtha.2009.03.002
Pan A-P, Wang Q-M, Huang F, Huang J-H, Bao F-J, Yu A-Y (2015) Correlation among lens opacities classification system III grading, visual function index-14, pentacam nucleus staging, and objective scatter index for cataract assessment. Am J Ophthalmol 159(2):241–247
Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D, Wu SY (1993) The lens opacities classification system III. The longitudinal study of cataract study group. Arch Ophthalmol 111(6):831–836
Tan AC, Loon SC, Choi H, Thean L (2008) Lens Opacities Classification System III: cataract grading variability between junior and senior staff at a Singapore hospital. J Cataract Refract Surg 34(11):1948–1952. https://doi.org/10.1016/j.jcrs.2008.06.037
Weiner X, Baumeister M, Kohnen T, Buhren J (2014) Repeatability of lens densitometry using Scheimpflug imaging. J Cataract Refract Surg 40(5):756–763. https://doi.org/10.1016/j.jcrs.2013.10.039
Dobbs RE, Smith JP, Chen T, Knowles W, Hockwin O (1987) Long-term follow-up of lens changes with Scheimpflug photography in diabetics. Ophthalmology 94(7):881–890
Akagi Y, Yajima Y, Kador PF, Kuwabara T, Kinoshita J (1984) Localization of aldose reductase in the human eye. Diabetes 33(6):562–566
Tkachov SI, Lautenschläger C, Ehrich D, Struck HG (2006) Changes in the lens epithelium with respect to cataractogenesis—light microscopic and Scheimpflug densitometric analysis of the cataractous and the clear lens of diabetics and non-diabetics. Graefe's Arch Clin Exp Ophthalmol 244(5):596–602
Sasaki H, Hockwin O, Kasuga T, Nagai K, Sakamoto Y, Sasaki K (1999) An index for human lens transparency related to age and lens layer: comparison between normal volunteers and diabetic patients with still clear lenses. Ophthalmic Res 31(2):93–103
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
“All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (Ankara Numune Education and Research Hospital + E-16–971) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.”
Informed consent
“Informed consent was obtained from all individual participants included in the study.”
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Bayraktar Bilen, N., Sarıcaoğlu, M.S. Assessment of cataract forming effect of diabetes in young adults by lens densitometer. Int Ophthalmol 40, 3357–3362 (2020). https://doi.org/10.1007/s10792-020-01523-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10792-020-01523-0