Skip to main content

Advertisement

SpringerLink
Log in

Potentially inappropriate prescriptions of anticholinergic medications in patients with closed-angle glaucoma

  • Original Paper
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

Glaucoma is the leading cause for blindness after cataracts worldwide. The aim was to identify anticholinergic drugs prescribed to patients diagnosed with closed-angle glaucoma in Colombia.

Methods

This cross-sectional study identified the prescribing patterns of cholinergic antagonists related to the increased intraocular pressure in patients diagnosed with closed-angle glaucoma from a Colombian database. The Anticholinergic Drug Scale was used to quantify the anticholinergic burden.

Results

We identified 1958 patients with closed-angle glaucoma, with a mean age of 70.5 ± 10.3 years, 72.9% of whom were women. Cholinergic antagonists were prescribed in at least 32.4% of cases. An age range between 75 and 84 years (odds ratio (OR) 2.35, 95% confidence interval (CI) 1.366–4.059) and being aged 85 years or older (OR 3.40, 95% CI 1.809–6.425) were associated with a greater probability of receiving an anticholinergic burden between 1 and 2 points. Females (OR 1.54, 95% CI 1.096–2.181) had a higher probability of receiving an anticholinergic burden ≥ 3 points. Interactions between antiglaucoma medications and anticholinergic treatments were identified in 32.1% of the patients.

Conclusions

Most patients were prescribed multiple antiglaucoma medications, reflecting a large number of potentially inappropriate prescriptions, with anticholinergic drugs, related to the increased intraocular pressure.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Jonas JB, Aung T, Bourne RR et al (2017) Glaucoma. Lancet 390(10108):2183–2193

    Article  Google Scholar 

  2. Mantravadi AV, Vadhar N (2015) Glaucoma. Prim Care 42(3):437–449

    Article  Google Scholar 

  3. Zhao Y, Fu JL, Li YL et al (2015) Epidemiology and clinical characteristics of patients with glaucoma: an analysis of hospital data between 2003 and 2012. Indian J Ophthalmol 63(11):825–831

    Article  Google Scholar 

  4. Sawaguchi S, Sakai H, Iwase A et al (2012) Prevalence of primary angle closure and primary angle-closure glaucoma in a southwestern rural population of Japan: the Kumejima study. Ophthalmology 119(6):1134–1142

    Article  Google Scholar 

  5. Hohn R, Nickels S, Schuster AK et al (2018) Prevalence of glaucoma in Germany: results from the Gutenberg Health Study. Graefes Arch Clin Exp Ophthalmol 256(9):1695–1702

    Article  Google Scholar 

  6. Kolko M, Horwitz A, Thygesen J et al (2015) The prevalence and incidence of glaucoma in Denmark in a fifteen year period: a nationwide study. PLoS ONE 10(7):e0132048

    Article  Google Scholar 

  7. Tham YC, Li X, Wong TY et al (2014) Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology 121(11):2081–2090

    Article  Google Scholar 

  8. Ko YC, Liu CJ, Hsu WM et al (2015) Determinants and characteristics of angle-closure disease in an elderly Chinese population. Ophthalmic Epidemiol 22(2):109–115

    Article  Google Scholar 

  9. Sun X, Dai Y, Chen Y et al (2017) Primary angle closure glaucoma: what we know and what we don’t know. Prog Retin Eye Res 57:26–45

    Article  Google Scholar 

  10. Razeghinejad MR, Myers JS, Katz LJ (2011) Iatrogenic glaucoma secondary to medications. Am J Med 124(1):20–25

    Article  CAS  Google Scholar 

  11. Patel K, Patel S (2014) Angle-closure glaucoma. Dis Mon 60(6):254–262

    Article  Google Scholar 

  12. Ah-Kee EY, Egong E, Shafi A et al (2015) A review of drug-induced acute angle closure glaucoma for non-ophthalmologists. Qatar Med J 1:6

    Article  Google Scholar 

  13. Vélez-Gómez MC, Vásquez-Trespalacios EM (2018) Adherence to topical treatment of glaucoma, risk and protective factors: a review. Arch Soc Esp Oftalmol 93(2):87–92

    Article  Google Scholar 

  14. Nishtala PS, Salahudeen MS, Hilmer SN (2016) Anticholinergics: theoretical and clinical overview. Expert Opin Drug Saf 15(6):753–768

    Article  CAS  Google Scholar 

  15. Collamati A, Martone AM, Poscia A et al (2016) Anticholinergic drugs and negative outcomes in the older population: from biological plausibility to clinical evidence. Aging Clin Exp Res 28(1):25–35

    Article  Google Scholar 

  16. Carnahan RM, Lund BC, Perry PJ et al (2006) The Anticholinergic Drug Scale as a measure of drug-related anticholinergic burden: associations with serum anticholinergic activity. J Clin Pharmacol 46(12):1481–1486

    Article  CAS  Google Scholar 

  17. Fea AM, Dallorto L, Lavia C et al (2018) Long-term outcomes after acute primary angle closure of Caucasian chronic angle closure glaucoma patients. Clin Exp Ophthalmol 46(3):232–239

    Article  Google Scholar 

  18. Lai JS, Liu DT, Tham CC et al (2001) Epidemiology of acute primary angle-closure glaucoma in the Hong Kong Chinese population: prospective study. Hong Kong Med J 7(2):118–123

    CAS  PubMed  Google Scholar 

  19. Chua PY, Day AC, Lai KL, et al. (2017) The incidence of acute angle closure in Scotland: a prospective surveillance study. Br J Ophthalmol. https://doi.org/10.1136/bjophthalmol-2017-310725. Epub ahead of print

  20. Rieger-Reyes C, Rubio-Galán FJ (2013) Glaucoma: pharmacological implications. Semergen 39(1):26–33

    Article  CAS  Google Scholar 

  21. Conlon R, Saheb H, Ahmed II (2017) Glaucoma treatment trends: a review. Can J Ophthalmol 52(1):114–124

    Article  Google Scholar 

  22. Kim CY, Park KH, Ahn J et al (2017) Treatment patterns and medication adherence of patients with glaucoma in South Korea. Br J Ophthalmol 101(6):801–807

    Article  Google Scholar 

  23. Chassid O, Epstein I, Sharabi-Nov A et al (2018) Prevalence of glaucoma in the Israeli Arab population. Int J Ophthalmol 11(1):163–165

    PubMed  PubMed Central  Google Scholar 

  24. Machado-Alba J, Hoyos-Soto V (2014) Frequency of coprescription and potential risk of bronchospasm in colombian patients users of topical antiglaucomatous betablockers and bronchodilators. Vitae 21:107–113

    Google Scholar 

  25. Kalouda P, Keskini C, Anastasopoulos E et al (2017) Achievements and limits of current medical therapy of glaucoma. Dev Ophthalmol 59:1–14

    Article  Google Scholar 

  26. Bower T, Samek DA, Mohammed A et al (2018) Systemic medication usage in glaucoma patients. Can J Ophthalmol 53(3):242–245

    Article  Google Scholar 

  27. Gerretsen P, Pollock BG (2011) Drugs with anticholinergic properties: a current perspective on use and safety. Expert Opin Drug Saf 10(5):751–765

    Article  Google Scholar 

  28. O’Mahony D, O’Sullivan D, Byrne S et al (2015) STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing 44(2):213–218

    Article  Google Scholar 

  29. Badhu BP, Bhattarai B, Sangraula HP (2013) Drug-induced ocular hypertension and angle-closure glaucoma. Asia Pac J Ophthalmol (Phila) 2(3):173–176

    Article  CAS  Google Scholar 

  30. Khurana AK, Khurana B, Khurana AK (2012) Drug-induced angle-closure glaucoma. J Curr Glaucoma Pract 6(1):6–8

    Article  Google Scholar 

Download references

Acknowledgements

We thank Soffy Claritza López for her work in obtaining the database.

Funding

This work did not receive funding.

Author information

Authors and Affiliations

  1. Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A, Calle 105 No. 14-140, Pereira, Risaralda, 660003, Colombia

    Luis Fernando Valladales-Restrepo & Jorge Enrique Machado-Alba

  2. Biomedicina, Fundación Universitaria Autónoma de las Américas, Pereira, Colombia

    Luis Fernando Valladales-Restrepo

Authors
  1. Luis Fernando Valladales-Restrepo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jorge Enrique Machado-Alba
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jorge Enrique Machado-Alba.

Ethics declarations

Conflict of interests

The authors declare that they have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Valladales-Restrepo, L.F., Machado-Alba, J.E. Potentially inappropriate prescriptions of anticholinergic medications in patients with closed-angle glaucoma. Int Ophthalmol 40, 803–809 (2020). https://doi.org/10.1007/s10792-019-01241-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-019-01241-2

Keywords

Search

Navigation