Skip to main content

Advertisement

SpringerLink
Log in

Intravitreal anti-VEGF treatment for choroidal neovascularization secondary to punctate inner choroidopathy

  • Original Paper
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To assess the outcome of patients with choroidal neovascularization (CNV) secondary to punctate inner choroidopathy (PIC) receiving intravitreal anti-VEGF (vascular endothelial growth factor) injections.

Methods

Sixteen eyes of 16 patients diagnosed with CNV secondary to PIC were retrospectively assessed.

Results

Eleven women and five men with a mean age of 35 years (SD 11, range 16–56 years) received intravitreal anti-VEGF for PIC-related CNV. On average, 3.5 injections (SD 2.7, range 1–9) were given per eye. Thirteen eyes were treated with bevacizumab, two eyes with ranibizumab and one eye received both substances. The mean follow-up was 15 months (SD 11, range 6–40 months). BCVA improved in eight eyes (mean Δ +2.8 lines), remained stable in four eyes and decreased in four eyes (mean Δ −4.3 lines).

Conclusions

CNV development is a frequent complication of PIC. Intravitreal anti-VEGF therapy seems to be safe and effective for PIC-related CNV.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Amer R, Lois N (2011) Punctate inner choroidopathy. Surv Ophthalmol 56(1):36–53

    Article  PubMed  Google Scholar 

  2. Zhang H, Liu Z, Sun P, Gu F (2012) Intravitreal bevacizumab as primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy: results of a 1-year prospective trial. Retina 32(6):1106–1113

    Article  PubMed  CAS  Google Scholar 

  3. Campos J, Campos A, Mendes S, Neves A, Beselga D, Castro Sousa JP (2014) Punctate inner choroidopathy: a systematic review. Med Hypothesis Discov Innov Ophthalmol 3(3):76–82

    PubMed  PubMed Central  Google Scholar 

  4. Watzke RC, Packer AJ, Folk JC, Benson WE, Borgess D, Ober RR (1984) Punctate inner choroidopathy. Am J Ophthalmol 98(5):572–584

    Article  PubMed  CAS  Google Scholar 

  5. Leung TG, Moradi A, Liu D, Nguyen QD, Dunn JP, Burkholder B, Butler NJ, Ostheimer T, Thorne JE (2014) Clinical features and incidence rate of ocular complications in punctate inner choroidopathy. Retina 34(8):1666–1674

    Article  PubMed  Google Scholar 

  6. Diaz RI, Sigler EJ, Rafieetary MR, Calzada JI (2015) Ocular histoplasmosis syndrome. Surv Ophthalmol 60:279–295

    Article  PubMed  Google Scholar 

  7. Amaro MH, Muccioli C, Abreu MT (2007) Ocular histoplasmosis-like syndrome: a report from a nonendemic area. Arq Bras Oftalmol 70(4):577–580

    Article  PubMed  Google Scholar 

  8. Watzke RC, Klein ML, Wener MH (1998) Histoplasmosis-like choroiditis in a nonendemic area: the northwest United States. Retina 18(3):204–212

    Article  PubMed  CAS  Google Scholar 

  9. Essex RW, Wong J, Fraser-Bell S, Sandbach J, Tufail A, Bird AC, Dowler J (2010) Punctate inner choroidopathy: clinical features and outcomes. Arch Ophthalmol 128(8):982–987

    Article  PubMed  Google Scholar 

  10. Chatterjee S, Gibson JM (2003) Photodynamic therapy: a treatment option in choroidal neovascularisation secondary to punctate inner choroidopathy. Br J Ophthalmol 87(7):925–927

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. Brueggeman RM, Noffke AS, Jampol LM (2002) Resolution of punctate inner choroidopathy lesions with oral prednisone therapy. Arch Ophthalmol 120(7):996

    Article  PubMed  Google Scholar 

  12. Gerstenblith AT, Thorne JE, Sobrin L, Do DV, Shah SM, Foster CS, Jabs DA, Nguyen QD (2007) Punctate inner choroidopathy: a survey analysis of 77 persons. Ophthalmology 114(6):1201–1204

    Article  PubMed  Google Scholar 

  13. Patel KH, Birnbaum AD, Tessler HH, Goldstein DA (2011) Presentation and outcome of patients with punctate inner choroidopathy at a tertiary referral center. Retina 31(7):1387–1391

    Article  PubMed  Google Scholar 

  14. Olsen TW, Capone A, Sternberg P, Grossniklaus HE, Martin DF, Aaberg TM (1996) Subfoveal choroidal neovascularization in punctate inner choroidopathy. Surgical management and pathologic findings. Ophthalmology 103(12):2061–2069

    Article  PubMed  CAS  Google Scholar 

  15. Brown J, Folk JC, Reddy CV, Kimura AE (1996) Visual prognosis of multifocal choroiditis, punctate inner choroidopathy, and the diffuse subretinal fibrosis syndrome. Ophthalmology 103(7):1100–1105

    Article  PubMed  Google Scholar 

  16. Wachtlin J, Heimann H, Behme T, Foerster MH (2003) Long-term results after photodynamic therapy with verteporfin for choroidal neovascularizations secondary to inflammatory chorioretinal diseases. Graefe’s Arch Clin Exp Ophthalmol 241:899–906

    Article  CAS  Google Scholar 

  17. Carneiro AM, Silva RM, Veludo MJ, Barbosa A, Ruiz-Moreno JM, Falcao MS, Brandao EM, Falcao-Reis FM (2011) Ranibizumab treatment for choroidal neovascularization from causes other than age-related macular degeneration and pathological myopia. Ophthalmologica 225(2):81–88

    Article  PubMed  CAS  Google Scholar 

  18. Rishi P, Gupta A, Rishi E, Shah BJ (2013) Choroidal neovascularization in 36 eyes of children and adolescents. Eye 27(10):1158–1168

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. Schadlu R, Blinder KJ, Shah GK, Holekamp NM, Thomas MA, Grand MG, Engelbrecht NE, Apte RS, Joseph DP, Prasad AG, Smith BT, Sheybani A (2008) Intravitreal bevacizumab for choroidal neovascularization in ocular histoplasmosis. Am J Ophthalmol 145(5):875–878

    Article  PubMed  CAS  Google Scholar 

  20. Campos J, Campos A, Beselga D, Mendes S, Neves A, Sousa JP (2013) Punctate inner choroidopathy: a clinical case report. Case Rep Ophthalmol 4(3):155–159

    Article  PubMed  PubMed Central  Google Scholar 

  21. Hohberger B, Rudolph M, Bergua A (2015) Choroidal neovascularization associated with punctate inner choroidopathy: combination of intravitreal anti-VEGF and systemic immunosuppressive therapy. Case Rep Ophthalmol 6(3):385–389

    Article  PubMed  PubMed Central  Google Scholar 

  22. Mangat SS, Ramasamy B, Prasad S, Walters G, Mohammed M, Mckibbin M (2011) Resolution of choroidal neovascularization secondary to punctate inner choroidopathy (PIC) with intravitreal anti-VEGF agents: a case series. Semin Ophthalmol 26(1):1–3

    Article  PubMed  Google Scholar 

  23. Vossmerbaeumer U, Spandau UHM, Baltz SV, Wickenhaeuser A, Jonas JB (2008) Intravitreal bevacizumab for choroidal neovascularisation secondary to punctate inner choroidopathy. Clin Exp Ophthalmol 36(3):292–294

    Article  PubMed  Google Scholar 

  24. Weiss S, Winter R, Meyer MW (2012) Punctate inner choroidopathy—Improvement in vision after anti-VEGF and photodynamic therapy. An 18-month follow-up control. Ophthalmologe 109(2):149–154

    Article  PubMed  CAS  Google Scholar 

  25. Chan W, Lai TYY, Liu DTL, Lam DSC (2007) Intravitreal bevacizumab (avastin) for choroidal neovascularization secondary to central serous chorioretinopathy, secondary to punctate inner choroidopathy, or of idiopathic origin. Am J Ophthalmol 143(6):977–983

    Article  PubMed  CAS  Google Scholar 

  26. Menezo V, Cuthbertson F, Downes SM (2010) Positive response to intravitreal ranibizumab in the treatment of choroidal neovascularization secondary to punctate inner choroidopathy. Retina 30(9):1400–1404

    Article  PubMed  Google Scholar 

  27. Mansour AM, Mackensen F, Arevalo JF, Ziemssen F, Mahendradas P, Mehio-Sibai A, Hrisomalos N, Lai TY, Dodwell D, Chan WM, Ness T, Banker AS, Pai SA, Berrocal MH, Tohme R, Heiligenhaus A, Bashshur ZF, Khairallah M, Salem KM, Hrisomalos FN, Wood MH, Heriot W, Adan A, Kumar A, Lim L, Hall A, Becker M (2008) Intravitreal bevacizumab in inflammatory ocular neovascularization. Am J Ophthalmol 146(3):410–416

    Article  PubMed  CAS  Google Scholar 

  28. Arevalo JF, Adan A, Berrocal MH, Espinoza JV, Maia M, Wu L, Roca JA, Quiroz-Mercado H, Ruiz-Moreno JM, Serrano MA (2011) Intravitreal bevacizumab for inflammatory choroidal neovascularization: results from the Pan-American Collaborative Retina Study Group at 24 months. Retina 31(2):353–363

    Article  PubMed  CAS  Google Scholar 

  29. Winterhalter S, Joussen AM, Pleyer U, Stübiger N (2012) Inflammatory choroidal neovascularisations. Klin Monatsbl Augenheilkde 229(9):897–904

    Article  CAS  Google Scholar 

  30. Pachydaki SI, Jakobiec A, Bhat P, Sobrin L, Michaud NA, Seshan SV, D’Amico DJ (2012) Surgical management and ultrastructural study of choroidal neovascularization in punctate inner choroidopathy. J Ophthal Inflamm Infect 2:29–37

    Article  Google Scholar 

  31. Neri P, Manoni M, Fortuna C, Lettieri M, Mariotti C, Giovannini A (2010) Association of systemic steroids and mycophenolate mofetil as rescue therapy for uveitic choroidal neovascularization unresponsive to the traditional immunesuppressants: interventional case series. Int Ophthalmol 30:583–590

    Article  PubMed  Google Scholar 

  32. Spaide RF (1999) Choroidal neovascularization in younger patients. Curr Opin Ophthalmol 10(3):177–181

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, University Medical Centre Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany

    T. Barth, H. Helbig & M.-A. Gamulescu

  2. Centre for Clinical Studies (ZKS), University Medical Centre Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany

    F. Zeman

Authors
  1. T. Barth
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Zeman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Helbig
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M.-A. Gamulescu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to T. Barth.

Ethics declarations

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical standards

Data collection was conducted in accordance with the ethical standards of the institutional research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Barth, T., Zeman, F., Helbig, H. et al. Intravitreal anti-VEGF treatment for choroidal neovascularization secondary to punctate inner choroidopathy. Int Ophthalmol 38, 923–931 (2018). https://doi.org/10.1007/s10792-017-0536-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-017-0536-0

Keywords

Search

Navigation