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Association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V polymorphisms with retinal angiomatous proliferation compared with typical age-related macular degeneration: a meta-analysis

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Abstract

Purpose

To compare the published results of studies on the genotype association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V in cases diagnosed as retinal angiomatous proliferation (RAP) versus neovascular age-related macular degeneration (AMD) or healthy controls.

Methods

Heterogeneity of studies was evaluated using Cochran’s Q test and I-square index. To modify the heterogeneity in the variables, we used random effects model. Meta-analysis was performed using STATA.

Results

Four studies were included with 1076 neovascular AMD patients, 222 RAP cases, and 2276 control subjects. Pooled overall odds ratios for RAP/AMD were 1.15 (95% CI 0.60–2.18) for GT versus GG, 3.52 (95% CI 1.25–9.91) for TT versus GG ARMS2, 0.98 (95% CI 0.22–4.29) for GA versus AA, 1.00 (95% CI 0.25–4.02) for GG versus AA CFHI62V, 0.57 (95% CI 0.35–0.93) for CT versus TT CFH Y402H, and 0.40 (95% CI 0.22–0.74) for CC versus TT CFH Y402H. Regression analysis showed that ARMS2 TT genotype has a statistically significant effect on RAP versus AMD compared to CFH genotypes (P < 0.001).

Conclusion

This meta-analysis disclosed a stronger effect of ARMS2 genotypes in RAP cases compared with CFH Y402H and I62V genotypes.

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Acknowledgements

The authors would like to acknowledge the support provided by Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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Authors and Affiliations

  1. Ocular Tissue Engineering Research Center, Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Pasdaran Ave, Boustan 9th street, Tehran, Iran

    Mohammad Hossein Jabbarpoor Bonyadi & Masoud Soheilian

  2. Department of Biostatistics and Epidemiology, Tehran University of Medical Sciences, Tehran, Iran

    Mehdi Yaseri

  3. Center of Excellence for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

    Mortaza Bonyadi

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  1. Mohammad Hossein Jabbarpoor Bonyadi
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  2. Mehdi Yaseri
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Correspondence to Mohammad Hossein Jabbarpoor Bonyadi.

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Jabbarpoor Bonyadi, M.H., Yaseri, M., Bonyadi, M. et al. Association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V polymorphisms with retinal angiomatous proliferation compared with typical age-related macular degeneration: a meta-analysis. Int Ophthalmol 37, 1397–1409 (2017). https://doi.org/10.1007/s10792-016-0413-2

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  • DOI: https://doi.org/10.1007/s10792-016-0413-2

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